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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Pharmaciana: Jurnal Kefarmasian Pharmascience Jurnal Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Insan Farmasi Indonesia Archives Pharmacia Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Indonesia Jurnal Ilmiah Nusantara
Naniek Widyaningrum
Prog. Studi Farmasi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang Fakultas Farmasi Universitas Wahid Hasyim (UNWAHAS) Semarang
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health Social Sciences

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EVALUASI SKALA NYERI PASCA OPERASI ORTOPEDI SETELAH PENGGUNAAN INJEKSI KETOROLAC DI RUMAH SAKIT ISLAM SULTAN AGUNG Timur, Willi Wahyu; Widyaningrum, Naniek
Archives Pharmacia Vol 3, No 1 (2021): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Evaluasi skala nyeri pada pasien pasca operasi penting dilakukan guna mengetahui keberhasilan dalam pengurangi tingkat rasa nyeri yang dialami pasien. Proses evaluasi tersebut dilihat dengan menilai tingkat skala nyeri yang dirasakan pada pasien sebelum menjalani operasi dan dilanjut dengan melihat tingkat skala nyeri pada pasien pasca operasi setelah diberikan injeksi ketorolac. Jenis penelitian yang digunakan adalah penelitian analitik observasional dengan rancangan penelitian secara retrospektif. Sampel yang diambil adalah pasien yang menjalani operasi ortopedi setelah diberikan injeksi ketorolac. Pengambilan data dilaksanakan pada bulan Agustus 2020, dengan jumlah sampel yang diambil sebanyak 98 pasien. Analisis dilakukan dengan melihat normalitas dan homogenitas, dan dilanjutkan dengan menganalisis menggunakan Wilcoxon. Hasil analisis Wilcoxon adalah p-value sebesar 0,000 < 0,05. Nilai p-value tersebut menunjukkan bahwa terdapat perbedaan yang bermakna antara nyeri sebelum operasi dengan nyeri pasca operasi setelah diberkan injeksi ketorolac. Kesimpulan yang diperoleh dari hasil analisis yang didapat menunjukan bahwa terdapat pengaruh yang ditimbulkan pada pasien sebelum menjalani operasi dengan pasien pasca operasi setelah diberikan injeksi ketorolac. Dengan rata-rata nilai skala nyeri sebelum operasi sebesar 4 dan setelah pemberian injeksi ketorolac pasca operasi sebesar 3.
Invitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer Widyaningrum, Naniek; Hussaana, Atina; Puspitasari, Nesya Ayu
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2020): June 2020
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1446.256 KB) | DOI: 10.30659/sainsmed.v11i1.7030

Abstract

INTRODUCTION:Cervical cancer is a malignant infectious disease caused by Human Papilloma Virus (HPV) in the cervix. Fig and olive oil containing flavonoid has been shown to have antioxidant and anticancer activity.OBJECTIVE:This study aimed to evaluate antioxidant and cytotoxic activity of combined Ficus carica L. and Olea europeae L. against HeLa cervical cancer cells.METHODS: This is an experimental study with a post-test only control group design. The HeLa cells were divided into 5 groups: fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1), positive control (doxorubicin). The cytotoxic and antioxidant activity were evaluated by using MTT Assay and DPPH, respectively. The cytotoxic results were analyzed using probit and antioxidant activity was analyzed by using linear regression to obtain IC50 values.RESULTS:The IC50 cytotoxic of fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1) with positive control (doxorubicin) were 13063,915 μg/mL, 679,593 μg/mL, 1562,356 μg/mL, 746,923μg/mL, 563,626 μg/mL and 13,707 μg/mL respectively. The IC50 antioxidant of fig extract, olive oil, and combination of fig extract and olive oil (3:1) was 105.9272 ppm, 23.1276 ppm, and 21,0689 ppm respectively.CONCLUSION:The combination of fig extract and olive oil (3:1) was shown to have the highest antioxidant and cytotoxic activity against HeLa cervical cancer cells.
Pengaruh Konsentrasi Ekstrak Etanolik Daun Teh Hijau (Camellia sinesis L.) dalam Sediaan Krim terhadap Sifat Fisik dan Aktivitas Antibakteri Widyaningrum, Naniek; Murrukmihadi, Mimiek; Ekawati, Syarifatun Karunia
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.531 KB) | DOI: 10.30659/sainsmed.v4i2.371

Abstract

Background: Green tea, is one of the herbs that have been proven to be effective as an anti-acne, among others.Green tea leaves contain 30-40% polyphenols known as catechins most of which are antimicrobial. For ease of use, the ethanolic leaf extract of green tea is made in cream. This study aimed to determine the effect of variations in the concentration of ethanolic extract of green tea leaves in cream on the physical properties and antibacterial activity of acne bacteria in particular.Design and Method: In this study, green tea leaf extract condensed obtained by maceration using 50% ethanol solution. Cream formula that is made in five concentration ethanolic extract of green tea leaves 1%, 3%, 5%, 7%, and 9% use a modified formula antiacne cream. Cream tested physical properties include homogenity, percent separation, dispersive power and adhesion. During the antibacterial activity was also tested. The data obtained were analyzed statistically using the non-parametric Kruskal-Wallis test followed by Mann Whitney test with a level of 95%.Results: The preparation cream ethanolic leaf green tea extract at various concentrations have good homogenity and not separate, the greater concentration of cream ethanolic extract of green tea leaves get smaller power and energy dispersive adhesion, whereas the inhibitory against Staphylococcus aureus bacteria is getting biger. Conclusion: Cream ethanolic extract of green tea leaves that are comparable with the positive control (Ristra acne creaming) the physical properties and the antibacterial activity at a concentration of 7% (Sains Medika, 4(2):147-156).
Development of Anti Acne Cream (w/o/w Multiple Emulsion) Containing Green Tea Leaf Waste Widyaningrum, Naniek
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.644 KB) | DOI: 10.30659/sainsmed.v8i2.2030

Abstract

Background: To date, green tea leaf waste is not well utilized, the waste is remain considered as a waste. Previous studies found that green tea leaf waste still have a fairly high EGCG content. EGCG has benefits as an antibacterial. Utilization of green tea leaf waste started from formulation until the diversification of multiple emulsion w/o/w products has not been reported.Objective: To develop anti acne cream (W/O/W) multiple emulsion containing green tea leaf waste and evaluate its antibacterial activity against acne-inducing bacteria of Propionibacterium acnes (P.acnes).Methods: Phase one of this research was green tea leaves was extracted by infundation and fractionation method using ethyl acetate and prepared in different concentration (1% to 6%). The second stage was ethyl acetate fraction of green tea leaf extract was tested for its antibacterial activity against P.acnes. Third stage was tested physical properties of formulation with w/o/w multiple emulsion.Results: The optimal antibacterial activity of ethyl acetate fraction of green tea leaf extract against P.acne was at the concentration of 6%, with inhibition zone of 32.6 mm ±0.57. The formula of w/o/w multiple emulsion loaded with green tea leaves waste of 6% active substance demonstrated a good physical properties which can spread 90.4 cm2 ± 0.03, pH 5.00 ± 0.02 and microscopic analysis showed multiple emulsion w/o/w.Conclusion: The concentration of 6% green tea leaf waste formulated in multiple emulsion had a good physical and antibacterial activity for a referred standard. It is necessary to test the stability of multiple emulsion formula.
OPTIMASI DAN FORMULASI SABUN MANDI CAIR UNTUK BAYI DARI MINYAK BUAH ALPUKAT (PERSEA AMERICANA MILL) Yuyun Darma Ayu Ningrum; Widyaningrum, Naniek; Sholeh, Aries Badrus; Aprilianti, Yunita
Jurnal Insan Farmasi Indonesia Vol 7 No 1 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i1.1964

Abstract

Halal guarantees are implemented to provide comfort, security and peace of mind for people when using halal products. The active ingredient used in this research is avocado oil (Persea Americana Mill). The formula in this research was determined using the Simple Lattice Design (SLD) method with a True Experimental Laboratory research design. In this research, several tests were carried out on the physical properties of the preparation, namely organoleptic test, pH test, foam stability test, viscosity test and homogeneity test. Based on the recommended simple lattice design (SLD) method, data from 10 evaluation tests of formulation preparations were tested and an optimal formulation was obtained. This formula contains a concentration of 12.5% coconut oil and 17.5% KOH. Overall, the physical evaluation of liquid soap formulations in this study shows that R1, R2, and R3 meet the requirements for baby liquid soap according to established standards. The liquid soap for babies obtained from this research has a characteristic liquid consistency, is yellowish white in color and has a distinctive odor. The achieved pH value, foam stability, viscosity and homogeneity are in accordance with established standards.
The Effectiveness of The Combination of Ginger (Zingiber Officinale) and Pomegranate (Punica Granatum) Towards Emesis Gravidarum Reduction in First Trimester Pregnant Women Widyaningrum, Naniek; Yuliana, Dewi; Oktasari, Masita
Jurnal Kesehatan Vol 14 No 3 (2023): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v14i3.3743

Abstract

This research aims to know the effectiveness of the combination of ginger and pomegranate towards emesis gravidarum reduction in first trimester pregnant women. This research was conducted pre-experimentally with a one group pretest-posttest design. The sampling technique used purposive sampling based on the exclusion and inclusion parameters. The research instrument used a 24-hour Pregnancy Unique of Emesis (PUQE-24) Scale questionnaire. The results indicated that the combination intervention of ginger and pomegranate obtained the most significant results from the intervention of ginger and pomegranate intervention with a p value of 0.000
Pengaruh Intervensi Pembelajaran terhadap Tingkat Kepuasan Pelanggan di Apotek Siroto Widyaningrum, Naniek; Saputri, Novitasari Adi; Arief, Thendi Abdul; Oktasari, Masita
Jurnal Pharmascience Vol 11, No 1 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i1.16112

Abstract

Sumber daya insani merupakan faktor penting dalam belangsungnya bisnis apotek. Pengetahuan tenaga teknis yang baik akan membuat pelanggan apotek merasa puas sehingga menjadi loyal dan menghasilkan word of mouth yang positif dan kepuasan pelanggan di apotek. Tujuan penelitian ini adalah untuk melihat ada atau tidaknya peningkatan pengetahuan tenaga teknis kefarmasian dengan dilakukan intervensi pembelajaran dan melihat adakah peningkatan kepuasan pelanggan apotek. Metode penelitian yang digunakan dalam penelitian ini adalah metode eksperimental. Penelitian ini dilakukan pada 5 tenaga teknis kefarmasian (TTK). Pemberian pre-test dan post-test dilakukan untuk mengukur tingkat pengetahuan TTK sebelum dan sesudah intervensi.  Intervensi yang diberikan berupa pembelajaran materi farmakoterapi (diare, konstipasi, GERD). Tingkat Kepuasan 30 pelanggan apotek terhadap pelayanan yang diberikan TTK diukur dengan kuesioner 5 dimensi SERVQUAL. Penelitian ini dilakukan di apotek Siroto pada Agustus-Desember 2023. Intervensi menghasilkan p-value<0,05 yang artinya terdapat pengaruh intervensi pembelajaran dalam meningkatkan pengetahuan tenaga teknis kefarmasian. Rata-rata nilai indeks kepuasan pelanggan didapatkan 90,79% yang termasuk dalam kategori tinggi. Kesimpulan dari penelitian tersebut menunjukkan peningkatan pengetahuan tenaga teknis kefarmasian dapat meningkatkan tingkat kepuasan pelanggan di apotek Siroto.  Kata Kunci: Sumber Daya Insani, Intervensi Pembelajaran, Tingkat Kepuasan, Tenaga Teknis Kefarmasian, SERVQUAL  Human resources are an important factor in the continuation of the pharmacy business. Good knowledge of technical personnel will make pharmacy customers feel satisfied so that they become loyal and generate positive word of mouth. In addition to knowledge, Islamic communication ethics also affect the level of customer satisfaction in pharmacies. The purpose of this study was to see whether or not there was an increase in the knowledge of pharmaceutical technical personnel by means of learning interventions and to see whether there was an increase in pharmacy customer satisfaction. The method used in this research was an experimental method. This study used a group of pharmaceutical technical staff with pre-test, intervention, and post-test. As for pharmacy customers with a questionnaire and a total of 30 respondents. This research was conducted at the Siroto pharmacy in August-December 2023. The intervention resulted in a p-value <0.05, which means that there was an effect of the learning intervention in increasing the knowledge of pharmacy technicians. The average value of the customer satisfaction index is 90.79% which is included in the high category. The conclusion showed  that increasing the knowledge of pharmaceutical technical personnel and the application of Islamic communication ethics can increase the level of customer satisfaction at the Siroto pharmacy.
KEPUASAN PASIEN TERHADAP PELAYANAN DOKTER KANDUNGAN BERBASIS SYARIAH DI APOTEK SIROTO SEMARANG Widyaningrum, Naniek; Sekar Tanjung, Ayu; Abdul Arief, Thendi; oktasari, Masita
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 7 No. 3 (2023): DESEMBER 2023
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v7i3.21094

Abstract

Kualitas pelayanan syariah adalah pelayanan yang dapat memberikan kepuasan pada setiap pasien dimana tata cara penyelenggaraannya sesuai dengan standar dan kode etik yang telah ditetapkan. Kepuasan menjadi bagian penting dalam pelayanan kesehatan sebab kepuasan pasien tidak dapat dipisahkan dari kualitas pelayanan kesehatan. Pelayanan dengan prinsip-prinsip syariah meliputi karakteristik Rabbaniyyah, Akhlaqiyyah, Waqi’iyah, dan Insaniyyah. Dalam mencapai kepuasan pasien terhadap pelayanan dokter kandungan di Apotek Siroto selain dipengaruhi oleh pelayanan yang diberikan, juga ditentukan oleh pengalaman dan pemikiran perorangan, sehingga dapat menjadi tolak ukur bagi petugas apotek untuk memperbaiki dan meningkatkan kepuasan pelayanan.  Tujuan penelitian ini untuk mengetahui tingkat kepuasan pasien terhadap pelayanan dokter kandungan di Apotek Siroto Semarang dan untuk mengetahui pengaruh pelayanan dengan prinsip-prinsip syariah terhadap kepuasan pasien. Jenis penelitian menggunakan observasional deskriptif dengan pendekatan kuantitatif dengan menggunakan sampel sebanyak 30 responden. Analisis data menggunakan SPSS 26 dengan uji validitas dan reliabilitas. Hasil penelitian ini didapatkan tingkat kepuasan pada indikator pelayanan berdasarkan Reliability didapatkan hasil 87,4% (sangat puas), Assurance 89,6% (sangat puas), Tangibes 89,8% (sangat puas), Empathy 89,4% (sangat puas), Responsiveness 90% (sangat puas), dan berdasarkan prinsip Syariah didapatkan hasil Rabbaniyyah 86,9%% (sangat puas), Akhlaqiyyah 90% (sangat puas), Waqi’iyyah 95,1% (sangat puas), dan Insaniyyah 96,7% (sangat puas). Pasien secara keseluruhan merasa sangat puas terhadap pelayanan yang ada di Apotek Siroto.
The Potential of Swiftlet Bird's Nest Extract (Aerodramus fucipaghus) as an Antioxidant and Serum Formulation Widyaningrum, Naniek; Putri, Chintiana Nindya; Arief, Thendi Abdul; Sofa, Nada Aini; Virdaus, Monica
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.27001

Abstract

The white swiftlet bird's nest (Aerodramus fucipaghus) constitutes one of nature's treasures endowed with diverse health benefits. The swiftlet bird's nest is a potential source of antioxidants, capable of counteracting free radicals contributing to premature ageing. It can be harnessed as a serum formulation featuring small molecules, facilitating deeper skin penetration, efficient delivery of highly concentrated active agents, and expedited resolution of skin issues. This study aimed to ascertain the swiftlet bird's nest serum's physical properties, physical stability, and antioxidant activities. Serum formulations span a range of concentrations: 10%, 20%, 30%, and 40%. Physical attributes of the serum, including organoleptic properties, homogeneity, pH, spreadability, and viscosity, were observed. Serum stability was assessed over a 21-day storage period. The antioxidant activity of the serum was gauged via DPPH assay, determining the IC50 values. The serum, across varying concentrations, exhibited commendable physical characteristics, satisfying stipulated criteria. Antioxidant activity was detected in the serum across a spectrum of concentrations, revealing IC50 values of 250.00 µg/mL, signifying a range from weak to strong efficacy (90.137 µg/mL). The swiftlet bird's nest serum with its concentration variants demonstrated physical stability during the 21-day storage duration. Drawing from the research, it can be deduced that the swiftlet bird's nest holds promise for development into a serum formulation that fulfils both physical and stability criteria, endowed with robust antioxidant activity. Notably, the swiftlet bird's nest serum at a 40% concentration exhibited potent antioxidant activity, manifesting an IC50 value of 90.137 µg/mL
TINGKAT KEPUASAN KONSUMEN TERHADAP PELAYANAN SWAMEDIKASI BERBASIS SYARIAH DI APOTEK SIROTO SEMARANG widyaningrum, naniek; Arief, Thendi Abdul; Tianingsih, Anis
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.41963

Abstract

Kepuasan konsumen adalah persepsi pelanggan terhadap kualitas layanan yang diterima dengan membandingkan harapan dan kenyataan yang diperoleh. Swamedikasi merupakan pengobatan sendiri dengan obat yang dapat dibeli tanpa resep dokter dan memiliki jaminan efektivitas serta keamanan. Konsep syariah menekankan bahwa pelayanan harus diberikan dengan baik dan tidak boleh merugikan pelanggan. Penelitian ini bertujuan untuk menilai tingkat kepuasan konsumen terhadap pelayanan swamedikasi berbasis syariah di Apotek Siroto Semarang. Metode penelitian yang digunakan adalah deskriptif dengan rancangan cross-sectional. Pengumpulan data dilakukan melalui penyebaran kuesioner kepada responden secara accidental sampling, yaitu pelanggan yang datang ke Apotek Siroto dan memenuhi kriteria inklusi serta eksklusi. Analisis data dilakukan menggunakan uji validitas dan reliabilitas, dimana uji signifikansi dapat dilakukan deingan meilakukan peirbandingan nilai rhitung deingan r tabeil, dimana rtabel yang diperoleh adalah 0,361, yang dihitung dari , untuk  nya senilai 30, dan nilai alpha-nya senilai 0,05. Hasil penelitian menunjukkan bahwa tingkat kepuasan konsumen Apotek Siroto Semarang mayoritas menyatakan sangat puas berdasarkan indeks kepuasan konsumen. Aspek kehandalan, ketanggapan, jaminan, empati, dan bukti fisik dalam pelayanan dinilai sangat baik oleh responden. Selain itu, penerapan konsep syariah dalam pelayanan juga mendapat respons positif dari konsumen, seperti pengingat membaca bismillah sebelum mengonsumsi obat, pelayanan dengan salam, serta sikap jujur dan peduli dari karyawan apotek. Penelitian ini mengindikasikan bahwa penerapan prinsip syariah dalam layanan swamedikasi dapat meningkatkan kepuasan pelanggan. Dengan mempertahankan dan meningkatkan kualitas layanan, Apotek Siroto dapat terus memberikan pelayanan terbaik kepada konsumennya.
Co-Authors Abdul Arief, Thendi Abdur Rosyid Adi, Reza Saeful Amalia Safitri Andriani, Ainul Anggoro Bhakti, Agung Dwi Aprilia, Laela Aprilianti, Yunita Arief, Thendi Abdul Atina Hussaana Chilmia Nurul Fatiha Dewi Yuliana Djoko Wahyono Evan Maulana, Alghafiqy Harya FEBRIANI, ANISA Hanafi, Anggit Naufal Hussana, Atina Maula, Ajni Minhatul Mimiek Murrukmihadi Oktasari, Masita Permata, Amaliyah Puspitasari, Nesya Ayu Putri, Chintiana Nindya Rahma, Dinda Rahmadani, Azmi Ramadhani, Adinda Fajrah Sampurno Sampurno Saputri, Novitasari Adi Sekar Tanjung, Ayu Sholeh, Aries Badrus Sofa, Nada Aini Syarifatun Karunia Ekawati Tianingsih, Anis Tiastuti, Memi Utami, Karina Misti Virdaus, Monica Willi Wahyu Timur Yuyun Darma Ayu Ningrum