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All Journal Journal of Community Development Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Octaviani, Olivia
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Computer Science & IT Medicine & Pharmacology Nursing Public Health Social Sciences

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PENGEMBANGAN TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS) PATCH METHYLDOPA SEBAGAI ANTIHIPERTENSI PADA KEHAMILAN Mayna, Mayna; Noval, Noval; Khairunnisa, Aisya Fitri; Octaviani, Olivia; Wilujeng, Wilujeng
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1647

Abstract

Hypertension in pregnancy including chronic hypertension with or without pre-eclampsia, gestational hypertension increases maternal and infant mortality significantly. The treatment for hypertension in pregnancy is the administration of methyldopa. Methyldopa transdermal patch is made by mixing the polymer first and then adding the active substance, namely methyldopa drug. It is intended that the polymer becomes an outer layer that controls the release of the drug. The resulting transdermal patch formulation was then evaluated, including organoleptic test, pH test, weight uniformity test, patch thickness test, folding resistance test, moisture test and penetration test using Franz diffusion cell. SPSS statistical data analysis. The penetration rate results showed F1 with 832.16 µg/cm2, F4 with 767.95 µg/cm2, F2 with 2819 µg/cm2 and F3 with 275.38 µg/cm2 all formulas have met the requirements. Based on the results of physical characteristics evaluation research, all formulas have met the requirements. The results of the in vitro evaluation of the methyldopa patch transdermal penetration test found that the difference in concentration in each formula had no significant effect on the penetration test. Based on physical evaluation parameters and in vitro penetration tests, the most optimal formula is F4 with the ratio of HPMC and ethyl cellulose (300:100) seen by fulfilling all physical characteristic evaluation tests and having a constant percent of cumulative amount to rise.
Pemberdayaan Kader Remaja "SEHATI" Dalam Upaya Mewujudkan Kelurahan Bebas Stunting Di Kelurahan Mantuil Maharani, Balqis; Saputra, Purnomo Adi; Octaviani, Olivia; Natalia, Jesika; Husniah, Zakiah; Sairah, St'; Nurfatriani, Nurfatriani; Pardede, Oisca Gabe Eidelwis Br.; Panabela, Sari; Nufus, Putri Hazatun; Suhartati, Susanti
Journal of Community Development Vol. 6 No. 1 (2025): August
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v6i1.1430

Abstract

The prevalence of stunting in South Kalimantan Province is 40.2% and in 2024 the number of stunted children in Mantuil Village is 72 children, one of the factors causing stunting is the high rate of anemia in adolescents in the Mantuil Village area, in 2023 a total of 115 or 35.7% of adolescent girls experienced anemia. South Banjarmasin Sub-district in 2022 also has the highest percentage of Early Marriage with 130 people dominated by people in the Mantuil Village area with 78 women and 9 men, the high number of Early Marriage cases is the biggest contributor to the incidence of stunting in the Mantuil Village area. The purpose of the activity is the formation of SEHATI Youth Cadres and a sustainable SEHATI Corner to improve public health status and increase adolescent knowledge as a community social action, as a reference in implementing stunting prevention programs in Mantuil Village. The method of implementing this activity which is carried out with the community and with the support of the local government consists of 3 stages, namely: SEHATI Youth Cadre Formation, Cadre Training and Sehati Corner Formation. Forming the Sehati Youth Cadre Institution with a total of 15 teenagers representing each RT in Mantuil Village, then empowering cadres through training activities on stunting, and simple health checks. The result of the implementation of this activity is the establishment of preventive and curative activities related to stunting prevention in Mantuil Village by the Sehati Youth Cadres through counseling activities for all teenagers in Mantuil Village. The evaluation showed a significant increase in the cadres' knowledge and skills. The average pretest score of participants was 45.3%, increasing to 93.3% in the posttest, with an average increase of 48%. Meanwhile, cadres' skills in conducting health education also improved, with an average pretest score of 23.7% and a posttest of 79.7%, showing an increase of 56%. Measurements were made through pretest and posttest tests which included stunting education material and cadre skill practice in conducting health counseling. With the SEHATI Corner, it is hoped that the sustainability of the program can be maintained and continue to provide benefits for adolescents in Mantuil Village in an effort to prevent stunting.
Co-Authors Husniah, Zakiah Khairunnisa, Aisya Fitri Maharani, Balqis Mayna, Mayna Natalia, Jesika Noval Noval Nufus, Putri Hazatun Nurfatriani, Nurfatriani Panabela, Sari Pardede, Oisca Gabe Eidelwis Br. Sairah, St' Saputra, Purnomo Adi Susanti Suhartati, Susanti Wilujeng, Wilujeng