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All Journal Ahmad Dahlan Medical Journal Innovative: Journal Of Social Science Research
Widodo, Ayudisty Ristika Kusumawardhani
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Other

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Potential Asiatic Acid in Centella asiatica (L.) Urban Towards NMDA Receptors of Alzheimer Dementia Patients In Silico Widodo, Ayudisty Ristika Kusumawardhani; Rahmayanti, Rahmayanti; Shahab, Fatinah
Ahmad Dahlan Medical Journal Vol. 4 No. 2 (2023): November 2023
Publisher : Universitas Ahmad Dahlan

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Abstract

Alzheimer's dementia can occur due to an increase in the neurotransmitter glutamate which can affect synaptic plasticity. Centella asiatica (L.) Urban is considered as one of the herbal plants used in the treatment of various diseases, such as medicine for leprosy, thrush, fever, hypertension, diabetes, and anemia and has a high antioxidant effect, one of the active ingredients is asiatic acid. This research to determine asiatic acid potential for NMDA receptors in Alzheimer's dementia. This research is an experimental research using a computer. The applications used were PyMOL for ligand preparation, PyRx for docking, and LigPlot for amino acid residue analysis. The interaction of receptor ligand binding is seen from the binding affinity score, the smaller the binding affinity score, the greater the potential between the ligand-receptors to interact. The pharmacokinetics of a compound are based on Lipinski's rule. In this study, the binding affinity score of - 8.3 was obtained and the Lipinski test showed the result of 'yes'.
Pengaruh Digitalisasi Sistem Informasi Manajemen Rumah Sakit Terhadap Efektivitas Administrasi Pasien Rohmah, Faizatur; Widodo, Ayudisty Ristika Kusumawardhani; Purwadhi, Purwadhi; Widjaja, Yani Restiani
Innovative: Journal Of Social Science Research Vol. 5 No. 4 (2025): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v5i4.19262

Abstract

Digitalization in the healthcare sector, particularly through the implementation of Hospital Management Information System (SIMRS), has become a primary focus in enhancing the effectiveness of patient administration. The aim of this study is to analyze the impact of SIMRS digitalization on the effectiveness of patient administration. The method employed is a literature review, which examines various relevant journals and previous studies on this topic. The analysis results indicate that SIMRS digitalization improves patient administration, as evidenced by service speed, data accuracy, ease of access to information, and patient satisfaction. Although there are challenges in implementation, such as infrastructure constraints and human resource readiness, the benefits derived from this digital system far outweigh the drawbacks. The conclusion of this study demonstrates that digitalization through SIMRS has a significant positive impact on the effectiveness of patient administration.
Co-Authors Fatinah Shahab Purwadhi Purwadhi Rahmayanti Rahmayanti ROHMAH, FAIZATUR Yani Restiani Widjaja, Yani Restiani