Article Per Year (5 Year)
p-Index From 2020 - 2025
0.61
P-Index
This Author published in this journals
All Journal Medula JURNAL KESEHATAN LINGKUNGAN: Jurnal dan Aplikasi Teknik Kesehatan Lingkungan Jurnal Aisyah : Jurnal Ilmu Kesehatan
Syaka, Muthiiah Khodista
Unknown Affiliation
Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Anemia Fanconi : Review Article Syaka, Muthiiah Khodista; Panjaitan, Vania Christy M; Gerliandi, Egi Oktarian; Dewi, Meidiana Kartika
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.931

Abstract

Fanconi anemia (AF) is a rare, multisystem genetic disorder that affects various physiological aspects, especially the bone marrow, and increases the risk of cancer, such as acute myeloid leukemia (AML) and head and neck cancer. This disease is caused by mutations in 23 genes of the FA/BRCA DNA repair pathway. This article presents the results of a literature study on FA, with a focus on etiology, pathophysiology, molecular pathology, diagnosis, risk factors, clinical symptoms, and management. Through literature study methods, the author collected information from national and international journal sources between 2012 and 2021. The etiology of FA involves mutations in 23 FA genes, with variations in carrier frequency depending on ethnic group. The pathophysiology of FA is related to the inability of cells to repair damaged DNA interstrand crosslinks (ICLs), which can lead to bone marrow failure. Molecular pathology involves the function of the FA/BRCA repair pathway and its impact on the genome. Diagnosis of FA requires clinical evaluation, molecular analysis, and bone marrow examination. Risk factors involve genetic aspects and specific carrier frequencies in ethnic populations. Clinical symptoms of FA involve anemia, infection, and somatic manifestations. Management of FA depends on the severity, with hematopoietic stem cell transplantation (HSCT) being the primary choice. HSCT from matched, nonmatched, or haploidentical donors has provided increasingly better results. This study underscores the importance of early diagnosis of FA to improve prognosis. Although HSCT is the primary treatment option, careful consideration of risks and benefits must be taken. The results of this literature study provide in-depth insight into FA, supporting appropriate monitoring and management efforts for individuals with this condition.
Larvacidal activity of Illicium verum ethanolic extract against Aedes aegypti Kurniawan, Betta; Saftarina, Fitria; Mustofa, Syazili; Syaka, Muthiiah Khodista
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3038

Abstract

Background: Chemical larvicides that have been used for a long time carry some risks by causing environmental risk. Besides, temephos has been documented to have the growth of resistance in various regions throughout the world among mosquito populations, consequently decreasing its effectiveness in eliminating the larval stage.  Therefore, developing alternative plant-based larvicides was considered a worthy step to reduce the risk of resistance to chemical larvicides. Illicium verum (IV), a plant-based spice, contains secondary metabolites such as flavonoids, saponins, tannins, and alkaloids acting as larvicidal agents. This study was conducted to attain Illicium verum ethanolic extract as an alternate plant-based mosquito larvicide against the dengue vector Aedes aegypti.Methods: The research design was an experimental method with a post-test-only control group design. The larvicide test in this study was divided into five groups with four repetitions and analyzed by Kruskal-Wallis test, post-hoc Mann-Whitney test, and probit analysis conducted with 95% confidence interval.Results: No significant difference was shown between concentrations of 0.25%, 0.125%, and 1% temephos, which showed a value of p0.05 on the Mann-Whitney test. The probit test showed the LC50 value was 0.476%, and the LC90 value was 2.42% at the maximum observation time. At the highest concentration, the LT50 value was 0.037 hours, and the LT90 value was 0.269 hours.Conclusion: This study reveals that natural substance of Illicium verum ethanolic extract surpassed 1% temephos as a botanical larvicide against Aedes aegypti larvae. This should be an environment-friendly solution to synthetic larvicide resistance.
Mortality Test Of Spice Plants As Biolarvicides Against Aedes Aegypti Larvae: Literature Review Syaka, Muthiiah Khodista; Kurniawan, Betta; Saftarina, Fitria
JURNAL KESEHATAN LINGKUNGAN: Jurnal dan Aplikasi Teknik Kesehatan Lingkungan Vol 22 No 1 (2025): Jurnal Kesehatan Lingkungan Volume 22 No. 1, Januari 2025
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Kesehatan Lingkungan Banjarbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/jkl.v22i1.902

Abstract

Dengue hemorrhagic fever (DHF) remains a global public health issue, transmitted through the bite of the Aedes aegypti mosquito. One method of disease prevention is the use of insecticides in the form of larvicides. Chemical larvicides have long been used but carry the risk of inducing resistance; therefore, research into the development of alternative larvicides is necessary. Indonesia’s rich biodiversity of spices presents a promising opportunity for the development of spice-based biolarvicides. This study was conducted in the form of a literature review, aiming to provide an overview of mortality tests of spice plants as biolarvicides against Aedes aegypti larvae. The findings from the reviewed literature indicate that two spices—tobacco leaves (Nicotiana tabacum) and zodia leaves (Evodia suaveolens)—in ethanol extract form achieved 100% larval mortality at all tested concentrations. The review also identified a variety of other spices with potential as biolarvicides based on larvicidal tests, with 9 out of 20 spices exhibiting 100% larval mortality rates in the summarized studies. It can thus be concluded that various spice plants demonstrate significant mortality test results and hold potential as alternative biolarvicides against Aedes aegypti larvae. Continued efforts to conduct standardization tests on these spice plants are necessary to develop them into standardized biolarvicidal agents.
Co-Authors Betta Kurniawan, Betta Dewi, Meidiana Kartika Fitria Saftarina Gerliandi, Egi Oktarian Panjaitan, Vania Christy M Syazili Mustofa