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All Journal Medula Juke Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya JITEK (Jurnal Ilmiah Teknosains) Jurnal Ilmu Kedokteran dan Kesehatan Acta Biochimica Indonesiana Jurnal Medika Malahayati SRIWIJAYA JOURNAL OF MEDICINE Jurnal Kesehatan Jurnal Aisyah : Jurnal Ilmu Kesehatan JK Unila (Jurnal Kedokteran Universitas Lampung) Indian Journal of Forensic Medicine & Toxicology Jurnal Kedokteran Raflesia Jurnal Pengabdian kepada Masyarakat Prosiding Konferensi Nasional PKM-CSR Jurnal Informatika Polinema (JIP) Medic Nutricia : Jurnal Ilmu Kesehatan Majority
Syazili Mustofa
Fakultas Kedokteran Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Significant Association of Adam 33 Polymorphism with COPD in Javanese Population of Indonesia Retno Ariza Soeprihatini Soemarwoto; Jamsari; Yanwirasti; Andika Chandra Putra; Syazili Mustofa; Wawan Abdullah Setiawan; Ifan Aulia Candra
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17045

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is one of World health cases that is commonlyknown, which is triggered by the combination of environmental factors especially cigarette smoking andgenetic factors. The association between A disintegrin and metalloprotease 33 (ADAM33) polymorphismsand COPD has been investigated and reported by other researchers. Objective: The main aim of this study isto identify the association between single nucleotide polymorphisms (SNPs) in ADAM 33 gene with COPDin the Javanese population in Lampung, Indonesia. Methods: A randomized cross-sectional study was usedin this research. PCR-Sequencing method was involved to analyze the polymorphic for three SNPs (T1, T2,and Q-1) of the ADAM33 gene. Statistical analysis data was performed in descriptive and comparative aswell as it was measured by parametric/non-parametric tests. Results: The results showed that the T2 GG,and T1AG genotypes in COPD group were significantly more frequent rather than in control group (p <0.05). In case of allele, it was found that the T1G and T2G was higher in COPD group rather than in thecontrol group (p = 0.440 and 0.131, respectively). Conclusion: The results clearly conclude that there wassignificant association between T1 and T2 polymorphisms of ADAM33 gene and COPD in the Javanesepopulation of Lampung, Indonesia.
The SNP rs13118928, rs1828591 and rs10519717 in the HHIP Gene are not Associated on COPD Susceptibility in Male Javanese Smokers Syazili Mustofa; Sutyarso; Muhartono; Yandri; Retno Ariza Soeprihatini Soemarwoto; Hendri Busman; Wawan Abdullah Setiawan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17108

Abstract

Background: Hedgehog Interacting Protein (HHIP) gene polymorphisms have an association on COPDhas been carried out in Europe and Asia but in Indonesia there is still very limited study on this type andthe largest ethnic group in Indonesia is the Javanese. Objective: To analyze the association between theHHIP gene polymorphism and the incidence of COPD in male Javanese smokers in Lampung, Indonesia.Method: In a case-control study in Javanese male smokers, three single nucleotide polymorphism (SNPs)in the HHIP gene were analyzed by Sanger sequencing method. There were 110 participants in this studywhich were divided into 2 groups, such as COPD group (55 participants) and control group (55 participants).Three SNPs in the gene (rs13118928, rs1828591 and rs10519717) were selected for genotyping. Genotypedistributions were compared between patients and controls. The statistical analysis was carried out with theSPSS program with a chi-square test. Result: The genotypic frequency of the HHIP gene sequence at theSNP position rs1828591, such as AA (52.72%), GG (3.63%) and AG (43.63%) in COPD group, while inthe control group such as AA (38.18%), GG (9.09%) and GG (52.72%; p > 0.05). The genotypic frequencyof the HHIP gene sequence at the SNP position rs13118928 consisted of AA (47.27%) and AG (53.72%)in the control group, while the COPD group consisted of AA (52.72%), GG (1.81%) and AG (45.45%; p> 0.05). The genotypic frequency of the HHIP gene sequence at the SNP position rs10519717 consistedof TT (34.54%), CC (14.56%) and CT (50.90%) in COPD group, while controls group consisted of TT(23.63%), CC (16.37%) and CT (60.00%; p > 0.05). The genotypic analysis of Three SNPs in HHIP genewere observed but showed no significant difference between case and control groups. Conclusion: Singlenucleotidevariants in the HHIP gene are not associated with COPD susceptibility in Javanese male smokers.
Hubungan Kejadian Hiperbilirubinemia dengan Inkompatibilitas ABO pada Bayi Baru Lahir di RSUD Abdul Moeloek Provinsi Lampung Mentariasih Maulida; Ratna Dewi PS; Syazili Mustofa
Medula Vol 11 No 1 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i1.205

Abstract

Bilirubin is a sequence product of red blood cells in the reticule-endothelial system. At excessive concentrations, about 5 mg/dL bilirubin will appear clinically as a yellow color on the skin and mucous membranes which is called jaundice. Jaundice can be physiological and pathological or commonly known as hyperbilirubinemia. Hyperbilirubinemia is a pathological condition that arises at the first day of birth and increasing of bilirubin levels 5 mg/dL per day rapidly, ABO incompatibility is the most common risk factor causes hyperbilirubinemia in newborns. ABO incompatibilities included in the main blood group antigen are blood group A and B which are the most common cases in newborns. This study aims to determine whether there is a relationship between incidences of hyperbilirubinemia with ABO incompatibility in newborns at Abdul Moeloek Hospital, Lampung. This is observational analytic study using cross sectional method. Total sampling method was done. Medical record was data source of this study. Data analysis was performed by chi-square test with p <0.05. The study used 325 medical records with 20% hyperbilirubinemia of newborn, 80% without hyperbilirubinemia, ABO incompatibility incidence is 20.9% and 79.1% without ABO incompatibility. Data analysis showed significant relationship of hipebilirubinemia with ABO incompatibility in newborns at Abdul Moeloek Hospital Lampung (p<0, 05). There study showed relationship between hypebilirubinemia with ABO incompatibility in newborn at Abdul Moeloek Hospital Lampung.
Pengaruh Pemberian Ekstrak Tempe terhadap Fungsi Hati dan Kerusakan Sel Hati Tikus Putih yang Diinduksi Parasetamol Syazili Mustofa
JUKE Unila Vol 3, No 01 (2013)
Publisher : Fakultas Kedokteran Universitas Lampung

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The influence of Piper retrofractum Vahl (Java's chili) extract towards lipid profile and histology of rats coronary artery with high-fat diet Syazili Mustofa; Ahmad A Anindito; Agustia Pratiwi; Aisyah A Putri; Muhammad Maulana
JUKE Unila Vol 4, No 07 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

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The Development of Medical Biochemistry Text Book to Improve the Quality of Learning of Basic Science 1 (BS1) Block at Medical Faculty the University of Lampung Syazili Mustofa; Evy Kurniawaty
JUKE Unila Vol 4, No 07 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

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PLASMODIUM KNOWLESI Betta Kurniawan; Jhons Fatriyadi Suwandi; Syazili Mustofa; Sri Janahtul Hayati
JURNAL KEDOKTERAN DAN KESEHATAN Vol 7, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V7I1.9657

Abstract

Malaria is a disease which caused by a parasite member of the species  of genus Plasmodium. Plasmodium knowlesiis a parasite which found in long-tailed macaques and was firstdiscovered in 1930 from the Macaca fascicularisspeciment from Singapore. In 2004 there was a reported P. knowlesiinfection in humans in Sarawak, Borneo Malaysia and this finding made P. falciparumas the fifth malaria parasite which infect humans. Plasmodium knowlesican sustain its erytrocytic cycle within 24 hours so it can caused a higher infection proggressifity than another parasites. Plasmodium knowlesi’s switch transmission from macaques to human  involve some factors, both demographically, environmentaly, and individual behavior.
The effect of mangrove (Rhizophora apiculata) bark extract ethanol on histopathology pancreas of male white rats Sprague Dawley strain exposed to cigarette smoke Syazili Mustofa; W Bahagia; Evi Kurniawaty; S Rahmanisa; Kholis Abdurachim Audah
Acta Biochimica Indonesiana Vol. 1 No. 1 (2018): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.v1i1.2

Abstract

Background: Cigarette smoke is free radical that causing some pathological conditions such as inflammation, proteolysis, and oxidative stress. In previous studies, mangrove (Rhizophora apiculata) bark extract showed the potential effect as an antioxidant. Mangrove and mangrove associates are abundant plants that grow throughout Indonesian shorelines that have high pharmaceutical and food values. Objective: The purpose of this study is to explore the potential of Rhizophora apiculata bark extract in protecting pancreas of male white rat (Rattus novergicus) Sprague Dawley strain exposed to cigarette smoke. Methods: This research was an experimental study using a posttest-only control group design. Mangrove bark was extracted by using the maceration method. Cigarette smoke exposure was performed using an electric cigarette. Liver inflammation is assessed histopathologically. Results: Significant results (p <0.05) were found between the control and cigarette groups as well as the cigarette and bark extract + control groups. The results were not significant (p> 0.05) between the control and the bark extract + cigarette. Conclusion : The administration of mangrove bark extract has a potential to protect the damage of pancreatic male white rats (Rattus norvegicus) Sprague Dawley strains exposed to cigarette smoke
The protective effect of Rhizophora apiculata bark extract against testicular damage induced by cigarette smoke in male rats Syazili Mustofa; Fauziah Hanif
Acta Biochimica Indonesiana Vol. 2 No. 1 (2019): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.v2i1.34

Abstract

Background: The mangrove bark extract (Rhizophora apiculata) is known to have the ability to inhibit the formation of free radicals, act as antioxidants, and anti-inflammatory. Objective: This study was attempted to investigate the potency of Rhizophora apiculata bark extracts as an antioxidant to protect rat testes from the damage due to cigarette smoke exposure. Methods: An experimental study using a posttest-only control group design was employed. Samples consisted of 25 male rats divided into 5 groups, namely K (-) not treated, K (+) exposed to cigarette smoke without the administration of mangrove bark extract, groups P1, P2, and P3 were exposed to cigarette smoke and each group received a dose of Rhizophora apiculata bark extracts every day for 30 days. Furthermore, P1 obtained 28.275 mg/KgBW, P2 was about 56.55 mg/kgBW, and P3 got 113.10 mg/kgBW. Results: Analysis using One Way ANOVA showed that there were significant effects of administration of extracts on the average number of primary spermatocytes and the thickness of the seminiferous tubules in the rats that have been exposed to cigarette smoke when compared to controls. The dose of extract that has the best effect was 113.10 mg/kgBW. Conclusion: Rhizophora apiculata bark extract is indicated to have a protective effect that can prevent damage in rats testes exposed to cigarette smoke.
Subacute toxicity test of Rhizophora apiculata bark extract on liver and pancreas histopathology of rats Syazili Mustofa; Isnamurti Ciptaningrum; Caesaria Sinta Zuya
Acta Biochimica Indonesiana Vol. 3 No. 2 (2020): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.v3i2.52

Abstract

Background: Rhizophora apiculata, one of the mangrove plant widely spread in Indonesia, can be developed as a medicinal plant. The extract of the bark has been found to have antioxidant and anti-inflammatory. However, the toxicity of Rhizophora apiculata has not been established yet. Objective: This research aims to evaluate the toxicity of ethanolic extract of Rhizophora apiculata bark on histopathological changes in rat’s liver and pancreas. Methods: Subacute toxicity study of the ethanol extract of Rhizophora apiculata bark was performed in healthy male rats by administering the extract at doses of 57, 114, 228, 456, and 918 mg/kg of body weight daily for 28 days. The subacute toxicity in rats was determined by histological analyses. Results: No significant adverse effect of the extract at dose 57 mg/kg was found. However at and over 114 mg/kg dose of the extract exhibited toxicities to the rats’ liver. In addition, the toxic effect appeared in rats’ pancreas at and over 228 mg/kg dose. Conclusions: Rhizophora apiculata bark extract showed no toxicity at or below 57 mg/kg. The ethanol extract from bark of Rhizophora apiculata showed toxicity at 114 mg/kg by subchronic toxicity.
Co-Authors Achmad Gozali Ade Yonata Adityo Wibowo, Adityo Adli, Farhan Kamali Agus Dwi Susanto Agus Wantoro Agustia Pratiwi agustyas tjiptaningrum Ahmad A Anindito Aisyah A Putri Ananta, Yoga andestya nanda pratama Andika Ridwan Nugraha Harahap Anggi Adelia Anggraeni Janar Wulan Annisa Adietya Pratama Antoni Antoni Asep Sukohar Aviv Fitria Yulia Ayu, Putu Ristyaning Benny Syahputra Gumay Betta Kurniawan Betta Kurniawan, Betta Budhi Antariksa Caesaria Sinta Zuya Caesarridha, Dhaifany Karissa Chicy WIdya Morfi Christi Natalia Sirait David Tongon Silaen Dheti Efrilia - Dimas Trend PB Dorisman, Hari Dwi Indria Anggraini Dwi Sarwindah Dyah Wulan Sumekar Rengganis Wardani Ekawati, Diyan Eksa, Dwi Robbiardy Elman Dani Firdaus Ersa, Rakhmigasti Citra Evi Kurniawaty Evy Kurniawaty Faisal Yunus Fauziah Hanif Fayza Syachrani Febrihartati, Isura Feby Aulia Hasanah Femmy Andrifianie Firantika Dias Puteri Fitria Saftarina Fitriyah Fitriyah Fransisca Sinaga Gerliandi, Egi Oktarian Gigih Setiawan Gilang Kukuh Megantoro Ginting, Bisart Giska Tri Putri Gusti Agung Putu Yogy Veda Ananta Hakim Alhaady Juhana Helmi Ismunandar Hendri Busman Hendri Busman Hetti Rusmini I Made Afryan SL I Made Galih Fradiva Giantara Ifan Aulia Candra Ilma Puteri Hutami Isnamurti Ciptaningrum Isura Febrihartati Jamsari Jamsari Jati, Pandu Kumaya Jhons Fatriyadi Suwandi Kevin Jeremia Purba Khoiri, Ratu Kirana Siva Kholis Abdurachim Audah Kurniawaty, Evi Linda Septiani Listiandoko, Raden Dicky Wirawan Lucky Togihon M. Rakha Gerizha Mallarangeng, Andi Nafisah Tendri Adjeng Mentariasih Maulida Mia Esta Poetri Afdal Faisal Mirza Purwitasari Muhammad Maulana Muhammad Ricky Ramadhian Muhartono NA, Ahmad Mufid Nadhifa, Farin Nadya Febriani Namdes, Fitri Cyntya Naufal Rivo Aditya Ni Sayu Putu Desya Laksmi Putri Nicholas Alfa Nickyta Yolandita Rosti Novita Carolia Novita Carolia Novita Carolia Nuriah Nuriah Nursidiq, Iqbal Muhammad Rafi Pinaka Baladika, Dimas Trend Poty, Pitha Maykania Puan Raissa Lenka Putra, Andika Chandra Putri Adilla Rahmasari, Fania Asfi Ramadhan, Muhammad Alif Ramadhana Komala Rasmi Zakiah Oktarlina Ratna Dewi PS Retno A S Soemarwoto Retno Ariza S Soemarwoto Retno Ariza S. Soemarwoto Retno Ariza Soeprihatini Soemarwoto Rheza Paleva Rika Lisiswanti Risal Wintoko Risti Graharti Rizki Putra Sanjaya Rizki Putra Sanjaya Rr Astri Nur Azizah Utama S Rahmanisa Sani, Nanda Apri Sarasmita Nirmala Dewi Septiani, Linda Shina Megaputri Shinta Nareswari, Shinta Silvia Andriani Sinaga, Fransisca TY Soemarwoto, Retno Ariza Soemarwoto, Retno Ariza Soeprihatini Soeprihatini Soemarwoto, Retno Ariza Soraya Rahmanisa Soraya Rahmanisa Soraya Rahmanisa Sri Janahtul Hayati Sri Janahtul Hayati Suharyani Suharyani Sukarti Sukarti Suryani Agustina Daulay Susianti Susianti Sutarto Sutarto Sutyarso Suwarno, Sukarti San Syaka, Muthiiah Khodista Syiefa Renanda Surya takhfa nur asyifa Tarigan, Clara Yulianti Terza Aflika Happy Tito Tri Saputra Tito Tri Saputra Tito Tri Saputra Tiwuk Susantiningsih Tri Umiana Soleha Tri Umiana Soleha Veny Anisya W Bahagia Wawan Abdullah Setiawan Wayan Ferly Aryana Winda Trijayanthi Utama, Winda Trijayanthi Wisnugroho, Cahyo Yana Ayu, Dwi Yandri Yanwirasti Yuningrum, Hesti Zulia Yasminanindita Fahmi Zulkifli