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All Journal e-CliniC Medical Scope Journal (MSJ) Jurnal Sehat Indonesia (JUSINDO)
Saleh, Denny
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Small Lymphocytic Lymphoma Presenting as Breast Mass: A Rare Case Report Manginstar, Christian; Merung, Marselus A.; Saleh, Denny; Merung, Marcella
e-CliniC Vol. 12 No. 2 (2024): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v12i2.46852

Abstract

Abstract: Primary breast lymphoma is rare and it accounts for around 0.5% of malignant breast neoplasms. Small lymphocytic lymphoma (SLL) is a subtype of non-Hodgkin lymphoma originating from a B-cell lineage. This report presents a case of primary SLL of the breast with lung metastasis that had excellent clinical response. We reported a 67-year-old female complained a right breast mass that suddenly appeared after she got massage on her right left arm. The mass was swollen and painless with no systemic complications. The specimen was submitted to histopathology department and it revealed small diffuse lymphocytic lymphoma. Chest X-ray showed a lung metastasis. The patient was then treated with CHOP regimens (Cyclophosphamid, Doxorubicin, Vincristin, and Prednison) and the clinical result was excellent. The side effects of the medication were minimal. In conclusion, primary breast lymphocytic lymphoma is rare and this case highlights the differential diagnosis for a painless breast mass. The treatment must be individualized and multimodal, with chemotherapy being the most accepted treatment. Keywords: breast lymphoma; breast mass; malignancy
Pediatric Pleomorphic Adenoma of Parotid Gland: A Case Report Suryoprabowo, Vincent; Lampus, Harsali F.; Candy, Candy; Saleh, Denny
Medical Scope Journal Vol. 7 No. 1 (2025): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v7i1.56144

Abstract

Abstract: Pleomorphic adenoma is a type of tumor that affects the parotid glands. It is also called a benign mixed tumor (BMT) because it has both epithelial and myoepithelial cells. This type of tumor is the most frequent parotid gland tumor, making up about 66% of all such tumors in parotid glands. We reported a case of 12-year-old male patient with a lump on his parotid gland, measured 7x3x3cm at Prof. Dr. R. D. Kandou Hospital Manado. CT Scan results of neck region of the patient revealed that there was a mass in the right side colli area and right frontal sinusitis A histopathological examination of the tumor tissue showed that it was encapsulated by connective tissue and composed of proliferating epithelial and myoepithelial tumor cells, some with clear nuclei, arranged in solid and microcystic patterns, and interspersed with fibromyxoid stroma. The patient was diagnosed as parotid gland adenoma, therefore, a parotidectomy was performed on him. He was discharged home and advised to return for a check-up one week later to remove the stitches. At the two-month follow-up visit, he was stable and did not require any additional therapy. In conclusion, a parotidectomy shows good result in the patient with parotid gland adenoma. However, due to the recurrence rate of parotid gland malignancies, several oncologists prefer to observe the patient periodically trough follow up at policlinic. Early detection and right management are required to achieve the best prognosis. Keywords: pleomorphic adenoma; pediatric patient; parotid gland
Neoadjuvant Lenvatinib in Advanced Unresectable Thyroid Carcinoma: Case Series and Literature Review Albert, Albert; Manginstar, Christian O.; Saleh, Denny; Merung, Marselus A.
e-CliniC Vol. 13 No. 1 (2025): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v13i1.58793

Abstract

Abstract: Lenvatinib, a tyrosine kinase inhibitor (TKI), has shown potential as a neoadjuvant therapy for inoperable thyroid cancer (TC). In this case series, we present three patients with unresectable thyroid tumors who responded favorably to lenvatinib treatment. A 60-year-old male with papillary thyroid cancer (PTC) experienced a 60% tumor volume reduction after five months of therapy. A 61-year-old male with medullary thyroid cancer (MTC) saw a 99% reduction after four months of lenvatinib and decrease of serum calcitonin and no residual disease six months after surgery. Lastly, a 67-year-old female with anaplastic thyroid cancer (ATC) showed a 70% tumor reduction and significant symptomatic relief. These cases highlight lenvatinib’s efficacy in reducing tumor size and stabilizing disease, improving surgical outcomes in patients initially deemed inoperable due to locally advanced tumors. Lenvatinib’s antitumor effects, driven by its antiangiogenic properties, suggest its potential as a valuable neoadjuvant treatment option in advanced thyroid cancer. Keywords: thyroid carcinoma; lenvatinib; case series
Efficacy and Safety of Drug Elution Bead-Transarterial Chemoembolization in Advanced Soft Tissue Sarcoma Albert, Albert; Manginstar, Christian O.; Saleh, Denny; Merung, Marselus A.
Medical Scope Journal Vol. 7 No. 2 (2025): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v7i2.58794

Abstract

Abstract: Soft-tissue sarcomas (STS) are rare and heterogeneous tumors originating from mesenchymal tissues. While surgical resection remains the primary treatment, not all patients are eligible for surgery, particularly in advanced stages. Drug-eluting bead transarterial chemoemboli zation (DEB-TACE) is a promising therapeutic option for such cases. This retrospective study evaluated the efficacy and safety of DEB-TACE in 30 patients with advanced STS at Prof. Dr. R. D. Kandou Hospital, Manado, from 2020 to 2023. The overall response rate (ORR) was 76.7% (p<0.05), with five patients achieving complete response and 18 showing partial response. The main adverse reactions included post-embolization syndrome (fever, pain, nausea, vomiting) and grade II or higher bone marrow suppression. Despite a morbidity rate of 93.3%, no treatment-related mortality was observed. In conclusion, DEB-TACE is an effective and safe treatment for advanced STS, providing superior short-term efficacy compared to traditional systemic chemotherapy. Keywords: soft tissue sarcoma; drug eluting bead; transarterial chemoembolization
Faktor Prediktor Terjadinya Delayed Hemothorax pada Pasien dengan Riwayat Trauma Tumpul Toraks di RSUP Prof Dr. R.D. Kandou Manado Stefanus, Gufi George; Sukanto, Wega; Tangkilisan, Adrian; Langi, F. L. Fredrik G.; Prasetyo, Eko; Tamburian, Christha; Saleh, Denny
Jurnal Sehat Indonesia (JUSINDO) Vol. 6 No. 02 (2024): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v6i02.133

Abstract

Trauma toraks merupakan penyebab signifikan dari morbiditas dan mortalitas, terutama dalam konteks multitrauma, dengan dampak kematian berkisar antara 20% hingga 25%. Penelitian ini bertujuan untuk mengetahui faktor prediktor terjadinya delayed hemothorax pada pasien dengan riwayat trauma tumpul toraks di RSUP Prof. Dr. R.D. Kandou Manado. Metode yang di guanakan metode penelitian dengan pendekatan kohort retrospektif, dengan cara consecutive sampling, analisis data dengan analisis deskriptif. Adapun hasil penelitian, ditemukan bahwa faktor prediktor yang signifikan adalah adanya fraktur tulang iga, jumlah fraktur iga 3 atau lebih, dan lokasi fraktur tulang iga. Usia dan kejadian kontusio paru tidak ditemukan sebagai faktor prediktor yang signifikan. Hasil penelitian juga menunjukkan bahwa pasien yang memiliki fraktur pada tulang iga ke 10-12, 6-9, dan 3-5 memiliki risiko lebih tinggi untuk mengalami delayed hemothorax.
Analisis Faktor yang Memengaruhi Keterlambatan Diagnosis dan Tatalaksana Pasien Kanker Payudara Stadium Lanjut di RSUP Prof. Dr. R. D. Kandou Manado Merung, Marselus A.; Saleh, Denny; Torar, Ridel
Medical Scope Journal Vol. 8 No. 2 (2026): MEDICAL SCOPE JOURNAL
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v8i2.67061

Abstract

Abstract: Most breast cancer cases in Indonesia are diagnosed in advanced stages, and even metastasis, underscoring the urgency of timely intervention. This study aimed to examine the effects of knowledge, attitudes and behaviors, fear, social support, and the Covid-19 pandemic on diagnostic delay and treatment delay, as well as to evaluate the impact of diagnostic delay on subsequent treatment delay at Prof. Dr. R. D. Kandou General Hospital. This was a quantitative analyticalal study with a cross-sectional design, using purposive non-probability sampling. A total of 112 patients with advanced-stage breast cancer were recruited between October and November 2024 and assessed using a structured questionnaire. Data were analyzed using SPSS with multiple linear regression.The results showed that knowledge, attitudes and behaviors, fear, social support, and the Covid-19 pandemic significantly influenced diagnostic delay (R²=0.605), with knowledge (β=0.537) and the Covid-19 pandemic (β=0.320) being the strongest predictors. These factors also significantly contributed to treatment delay (R²=0.948), with attitudes and behaviors (β=0.935) and social support (β=0.876) demonstrating the greatest effects. Furthermore, diagnostic delay exerted a positive and significant influence on treatment delay (R²=0.304, β=0.200). In conclusion, a multidimensional approach encompassing improved public health education, psychosocial support, and streamlined healthcare pathways is essential to mitigate delays in diagnosis and treatment, ultimately enhancing clinical outcomes for breast cancer patients. Keywords: breast cancer; diagnostic delay; treatment delay   Abstrak: Sebagian besar kasus kanker payudara di Indonesia ditemukan pada stadium lanjut, bahkan telah bermetastasis, yang menyoroti pentingnya intervensi tepat waktu. Penelitian ini bertujuan untuk menguji pengaruh pengetahuan, sikap dan perilaku, ketakutan, dukungan sosial, dan pandemi Covid-19 terhadap keterlambatan diagnosis dan keterlambatan pengobatan, serta dampak keterlambatan diagnosis terhadap keterlambatan pengobatan di RSUP Prof. Dr. R. D. Kandou. Jenis penelitian ialah analitik kuantitatif dengan desain potong lintang, menggunakan non-probability sampling dengan metode purposive sampling. Penelitian dilakukan dengan menggunakan kuesioner yang diberikan kepada 112 pasien kanker payudara stadium lanjut selama bulan Oktober hingga November 2024 dan data dianalisis menggunakan SPSS. Hasil penelitian menunjukkan bahwa pengetahuan, sikap dan perilaku, ketakutan, dukungan sosial, dan pandemi Covid-19 secara bermakna mempengaruhi keterlambatan diagnosis (R²=0,605). Pengetahuan (β=0,537) dan pandemi Covid 19 (β=0,320) merupakan faktor yang paling berpengaruh terhadap keterlambatan diagnosis. Faktor-faktor ini juga secara bermakna memengaruhi keterlambatan pengobatan (R²=0,948), dengan sikap dan perilaku (β=0,935) dan dukungan sosial (β=0,876) menunjukkan pengaruh terbesar. Keterlambatan diagnostik secara positif dan bermakna memengaruhi keterlambatan pengobatan (R²=0,304, β=0,200). Simpulan penelitian ini ialah pendekatan multidimensi, termasuk peningkatan edukasi publik, dukungan psikososial, dan peningkatan alur layanan, sangat penting untuk mengurangi keterlambatan ini dan pada akhirnya meningkatkan hasil pengobatan pasien. Kata kunci: kanker payudara; keterlambatan diagnosis; keterlambatan tatalaksana
Co-Authors Adrian Tangkilisan, Adrian Albert Albert Candy, Candy Eko Prasetyo Gufi George Stefanus, Gufi George Harsali F. Lampus Manginstar, Christian Manginstar, Christian O. Marselus A. Merung, Marselus A. Merung, Marcella Sukanto, Wega Suryoprabowo, Vincent Tamburian, Christha Torar, Ridel