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All Journal e-CliniC Medical Scope Journal (MSJ) Jurnal Sehat Indonesia (JUSINDO)
Saleh, Denny
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Medical Scope Journal (MSJ)

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Pediatric Pleomorphic Adenoma of Parotid Gland: A Case Report Suryoprabowo, Vincent; Lampus, Harsali F.; Candy, Candy; Saleh, Denny
Medical Scope Journal Vol. 7 No. 1 (2025): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v7i1.56144

Abstract

Abstract: Pleomorphic adenoma is a type of tumor that affects the parotid glands. It is also called a benign mixed tumor (BMT) because it has both epithelial and myoepithelial cells. This type of tumor is the most frequent parotid gland tumor, making up about 66% of all such tumors in parotid glands. We reported a case of 12-year-old male patient with a lump on his parotid gland, measured 7x3x3cm at Prof. Dr. R. D. Kandou Hospital Manado. CT Scan results of neck region of the patient revealed that there was a mass in the right side colli area and right frontal sinusitis A histopathological examination of the tumor tissue showed that it was encapsulated by connective tissue and composed of proliferating epithelial and myoepithelial tumor cells, some with clear nuclei, arranged in solid and microcystic patterns, and interspersed with fibromyxoid stroma. The patient was diagnosed as parotid gland adenoma, therefore, a parotidectomy was performed on him. He was discharged home and advised to return for a check-up one week later to remove the stitches. At the two-month follow-up visit, he was stable and did not require any additional therapy. In conclusion, a parotidectomy shows good result in the patient with parotid gland adenoma. However, due to the recurrence rate of parotid gland malignancies, several oncologists prefer to observe the patient periodically trough follow up at policlinic. Early detection and right management are required to achieve the best prognosis. Keywords: pleomorphic adenoma; pediatric patient; parotid gland
Efficacy and Safety of Drug Elution Bead-Transarterial Chemoembolization in Advanced Soft Tissue Sarcoma Albert, Albert; Manginstar, Christian O.; Saleh, Denny; Merung, Marselus A.
Medical Scope Journal Vol. 7 No. 2 (2025): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v7i2.58794

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Abstract: Soft-tissue sarcomas (STS) are rare and heterogeneous tumors originating from mesenchymal tissues. While surgical resection remains the primary treatment, not all patients are eligible for surgery, particularly in advanced stages. Drug-eluting bead transarterial chemoemboli zation (DEB-TACE) is a promising therapeutic option for such cases. This retrospective study evaluated the efficacy and safety of DEB-TACE in 30 patients with advanced STS at Prof. Dr. R. D. Kandou Hospital, Manado, from 2020 to 2023. The overall response rate (ORR) was 76.7% (p<0.05), with five patients achieving complete response and 18 showing partial response. The main adverse reactions included post-embolization syndrome (fever, pain, nausea, vomiting) and grade II or higher bone marrow suppression. Despite a morbidity rate of 93.3%, no treatment-related mortality was observed. In conclusion, DEB-TACE is an effective and safe treatment for advanced STS, providing superior short-term efficacy compared to traditional systemic chemotherapy. Keywords: soft tissue sarcoma; drug eluting bead; transarterial chemoembolization
Co-Authors Adrian Tangkilisan, Adrian Albert Albert Candy, Candy Eko Prasetyo Gufi George Stefanus, Gufi George Harsali F. Lampus Manginstar, Christian Manginstar, Christian O. Marselus A. Merung, Marselus A. Merung, Marcella Sukanto, Wega Suryoprabowo, Vincent Tamburian, Christha