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All Journal Jurnal Mandala Pharmacon Indonesia International Journal of Science and Society (IJSOC) Riset Informasi Kesehatan
Harfita, Nur Laily
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Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Riset Informasi Kesehatan

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Beta-sitosterol glycoside from Paraboea leuserensis and Cytotoxicity Test against MCF-7 Human Breast Cancer Cells Harfita, Nur Laily; Santoni, Adlis; Suryati, Suryati
Riset Informasi Kesehatan Vol 12 No 2 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i2.826

Abstract

Background: Paraboea leuserensis, a plant endemic to the Leuser Mountain in the provinces of Aceh and North Sumatra, has been traditionally used for medicinal purposes by chewing or boiling, addressing conditions such as stomachaches and providing stamina enhancement. This study aimed to isolate secondary metabolite compounds from Paraboea leuserensis and conduct in vitro anticancer tests. Method: The ethyl acetate extract was isolated through column chromatography, yielding beta-sitosterol glycoside, and was tested for bioactivity against human breast cancer cells MCF-7 using the MTT method. Results: The compound demonstrated activity against breast cancer cells (MCF-7) with an IC50 value of 24.83 mg/L. Conclusion: Paraboea leuserensis exhibits potential anticancer activity. The isolation of beta-sitosterol glycoside from the plant and its demonstrated activity against MCF-7 human breast cancer cells suggest a promising avenue for further exploration of the plant's anticancer properties.
Co-Authors Adlis Santoni Friendly Harizahahyu Harizahayu, Harizahayu Muhammad Fathoni Prayudani, Santi Suryati Suryati Yuyun Yusnida Lase