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All Journal Indonesian Journal of Tropical and Infectious Disease Genbinesia Journal of Biology
Kautsar, Radinal
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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In Silico Analysis of Inhibitor Potential of Punicalagin Compound in Pomegranate (Punica granatum) Against NS5 DENV-3 Protein Kautsar, Radinal; Rachmawati, Yuanita; Rokhim, Saiku; Sucipto, Teguh Hari; Damayanti, Mamik; Ramadhani, Aisyah Hadi
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.52320

Abstract

Indonesia is one of the Dengue Virus (DENV) endemic areas which are dominated by DENV-2 and DENV-3. Until now, no specific drug therapy has been found to cure Dengue Virus Infection (DVI). Punicalagin is one of the active compounds that have the potential to be used as an antiviral. Unfortunately, not many studies have used punicalagin as a DENV antivirus. This study aims to determine the inhibitory potential of punicalagin compounds against NS5 DENV-3 protein through molecular docking. Molecular docking was performed using AutoDock Tools, ChemDraw, and Discovery Studio Visualizer. The target protein used is NS5 DENV-3 protein with PDB ID code: 4V0Q. The ribavirin compound was used as a positive control. The results obtained show that the punicalagin compound has the ability to attach to target receptors in the C-Terminal domain complex. This docking produces a bond free energy (ΔG) of -6.39 kcal/mol. This result is better than the ΔG of the control compound. Punicalagin's Inhibition Constant (Ki) value also showed better results than ribavirin. So it can be seen that the compound punicalagin effectively inhibits DENV replication and has the potential as a DENV drug candidate. 
Frequency of ABO blood system type alleles in students of UIN Sunan Ampel Surabaya Kautsar, Radinal; Putri, Siti Aisyah Bisri; Azzhahara, Nabillah Ayu; Aini, Humayra Qurrata; Pradiptaadi, Brian Pramana Aprilio; Nabila, Salsa; Arrohmah, Robiatush Sholichah; Rachmawati, Yuanita
Genbinesia Journal of Biology Vol. 1 No. 3 (2022): July 2022
Publisher : Generasi Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55655/genbinesia.v1i3.27

Abstract

The commonly used human blood group system is the ABO system. Determination of blood group is important in blood transfusion activities. The purpose of this study was to determine the frequency of the ABO blood group system and the frequency of the ABO blood group allele in students of the Biology and Science Education study program at UIN Sunan Ampel Surabaya. Determination of blood group was carried out by the Slide Test method which was carried out randomly with a sample of 90 people. Determination of blood group is done by the principle of agglutination that occurs between antigens and antibodies. The results showed the frequency of blood group ABO system: A (20%); B (24%); AB (10%); O (46%). IA allele frequency (0.13); IB (0.07); IO (0.8). The proportion of the highest frequency of blood type is blood type O. These results indicate that the distribution of blood type O among students at UIN Sunan Ampel Surabaya is relatively the same as the results of other studies conducted in Indonesia.
Co-Authors Aini, Humayra Qurrata Arrohmah, Robiatush Sholichah Azzhahara, Nabillah Ayu DAMAYANTI, MAMIK Nabila, Salsa Pradiptaadi, Brian Pramana Aprilio Putri, Siti Aisyah Bisri Ramadhani, Aisyah Hadi Saiku Rokhim Teguh Hari Sucipto, Teguh Hari Yuanita Rachmawati