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All Journal Pharmaceutical Journal of Indonesia CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang
Wijaya, Surya Oto
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Gambaran Kuantitatif Antibiotik Menggunakan Metode Defined Daily Dose (DDD) Di Ruang Rawat Inap RSPI Prof. Dr. Sulianti Saroso Pada Januari-Juni 2019 Mariana, Nina; Indriyati, Indriyati; Widiantari, Aninda Dinar; Taufik, Muhammad; Wijaya, Chandra; Hartono, Teguh Sarry; Wijaya, Surya Oto; Firmansyah, Iman
Pharmaceutical Journal of Indonesia Vol. 7 No. 1 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.007.01.6

Abstract

Latar Belakang. Penggunaan antibiotik yang tepat dapat meminimalkan terjadinya resistensi antibiotika. selain penghematan secara ekonomi. Oleh karena itu perlu adanya pemantauan dan evaluasi penggunaan antibiotik di fasilitas kesehatan dan feedback terhadap peresepan antibiotik. Tujuan penelitian ini adalah untuk mengevaluasi secara kuantitatif penggunaan antibiotik baik jenis dan jumlah antibiotik berdasarkan klasifikasi Anatomical Therapeutic Chemical (ATC)  dengan  pengukuran Defined Daily Dose (DDD) sebagai metode terstandar pengukuran kuantitas penggunaan antibiotik. Metode. Penelitian ini adalah  observasional deskriptif,  menggunakan rancangan potong lintang pada periode Januari-Juni 2019 pada RSPI Prof. Dr. Sulianti Saroso. Kriteria inklusi berupa kasus pasien dewasa bukan kasus TB yang dirawat di ruang rawat inap non ICU dan penggunaan antibiotiknya masuk ke dalam klasifikasi Anatomical Therapueutic Chemical (ATC). Berdasarkan data rekam medik  terkumpul dalam lembar pengumpul data.Hasil. Sebanyak 96 status rekam medik dengan 51 kasus penyakit infeksi non bedah dan 45 kasus infeksi bedah yang menggunakan antibiotik. Difteri merupakan kasus infeksi non bedah terbanyak yaitu 10.5%. Distribusi penggunaan antibiotik golongan beta laktam kombinasi inhibitor betalaktamase sebanyak  37.28%, golongan sefalosporin  33.90%, golongan penisilin sebanyak 10,17%. Berdasarkan nilai DDD/patient day antibiotik Penicillin Prokain memiliki nilai tertiggi yaitu sebesar 97.22 dan nilai DDD/patient day terendah yaitu pada antibiotik meropenem yaitu sebesar 0.22.  Kesimpulan. Pada penelitian ini, kuantitas antibiotik berdasarkan nilai DDD/100 patient day tertinggi adalah Penisilin Prokain, seiring dengan difteri sebagai kasus penyakit infeksi non bedah terbanyak pada periode Januari-Juni 2019.  Mengingat penelitian dilakukan pada saat kejadian luar biasa difteri, perlu dilakukan penelitian lebih lanjut pada periode berikutnya sebagai data pembanding kuantitas antibiotik di masa depan.
Differential Effects of Albumin Infusion between ICU and Non-ICU Hypoalbuminemia Patients Mariana, Nina; Wijaya, Surya Oto; Setyawati, Rumaisah; Maemun, Siti; Nafrialdi, Nafrialdi
Pharmaceutical Journal of Indonesia Vol. 7 No. 1 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.007.01.3

Abstract

Background: Hypoalbuminemia is frequent among hospitalized patients and is associated with poor outcomes. ICU patients are widely associated with more severe condition making albumin correction seems to be less effective. This study was aimed to compare the results of albumin correction in ICU and non-ICU patients at Sulianti Saroso Hospital, Jakarta. Methods: A cross sectional study was conducted on adult patients in ICU and non-ICU wards who received intravenous albumin infusion at Sulianti Saroso hospital, between January 2013 to March 2018. Paired t-test was used to analyze the changes of albumin level before and after albumin infusion. Results: 123 ICU patients (41 sepsis, 82 non-sepsis) and 206 non-ICU patients (34 sepsis, 172 non-sepsis) who received 20% or 25% albumin infusions were included. Significant increase in albumin levels were observed in sepsis patients both in ICU and non-ICU, while in non-sepsis patients, the significant increase only observed in non-sepsis patients. Overall, mean increase in albumin levels in ICU-and non-ICU patients were 0.13 (0.63) g/dL vs 0.35(0.54) g/dL, respectively (P= < 0,001). Conclusion: Non-ICU patients show better response to albumin infusion compared to ICU patients. This difference is presumably due to different degree of inflammation. It is suggested that the quantity needed for albumin infusion is calculated differently according to clinical condition of the patients   
Gambaran Kuantitatif Antibiotik Menggunakan Metode Defined Daily Dose (DDD) Di Ruang Rawat Inap RSPI Prof. Dr. Sulianti Saroso Pada Januari-Juni 2019 Mariana, Nina; Indriyati, Indriyati; Widiantari, Aninda Dinar; Taufik, Muhammad; Wijaya, Chandra; Hartono, Teguh Sarry; Wijaya, Surya Oto; Firmansyah, Iman
Pharmaceutical Journal of Indonesia Vol. 7 No. 1 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.007.01.6

Abstract

Latar Belakang. Penggunaan antibiotik yang tepat dapat meminimalkan terjadinya resistensi antibiotika. selain penghematan secara ekonomi. Oleh karena itu perlu adanya pemantauan dan evaluasi penggunaan antibiotik di fasilitas kesehatan dan feedback terhadap peresepan antibiotik. Tujuan penelitian ini adalah untuk mengevaluasi secara kuantitatif penggunaan antibiotik baik jenis dan jumlah antibiotik berdasarkan klasifikasi Anatomical Therapeutic Chemical (ATC)  dengan  pengukuran Defined Daily Dose (DDD) sebagai metode terstandar pengukuran kuantitas penggunaan antibiotik. Metode. Penelitian ini adalah  observasional deskriptif,  menggunakan rancangan potong lintang pada periode Januari-Juni 2019 pada RSPI Prof. Dr. Sulianti Saroso. Kriteria inklusi berupa kasus pasien dewasa bukan kasus TB yang dirawat di ruang rawat inap non ICU dan penggunaan antibiotiknya masuk ke dalam klasifikasi Anatomical Therapueutic Chemical (ATC). Berdasarkan data rekam medik  terkumpul dalam lembar pengumpul data.Hasil. Sebanyak 96 status rekam medik dengan 51 kasus penyakit infeksi non bedah dan 45 kasus infeksi bedah yang menggunakan antibiotik. Difteri merupakan kasus infeksi non bedah terbanyak yaitu 10.5%. Distribusi penggunaan antibiotik golongan beta laktam kombinasi inhibitor betalaktamase sebanyak  37.28%, golongan sefalosporin  33.90%, golongan penisilin sebanyak 10,17%. Berdasarkan nilai DDD/patient day antibiotik Penicillin Prokain memiliki nilai tertiggi yaitu sebesar 97.22 dan nilai DDD/patient day terendah yaitu pada antibiotik meropenem yaitu sebesar 0.22.  Kesimpulan. Pada penelitian ini, kuantitas antibiotik berdasarkan nilai DDD/100 patient day tertinggi adalah Penisilin Prokain, seiring dengan difteri sebagai kasus penyakit infeksi non bedah terbanyak pada periode Januari-Juni 2019.  Mengingat penelitian dilakukan pada saat kejadian luar biasa difteri, perlu dilakukan penelitian lebih lanjut pada periode berikutnya sebagai data pembanding kuantitas antibiotik di masa depan.
Differential Effects of Albumin Infusion between ICU and Non-ICU Hypoalbuminemia Patients Mariana, Nina; Wijaya, Surya Oto; Setyawati, Rumaisah; Maemun, Siti; Nafrialdi, Nafrialdi
Pharmaceutical Journal of Indonesia Vol. 7 No. 1 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.007.01.3

Abstract

Background: Hypoalbuminemia is frequent among hospitalized patients and is associated with poor outcomes. ICU patients are widely associated with more severe condition making albumin correction seems to be less effective. This study was aimed to compare the results of albumin correction in ICU and non-ICU patients at Sulianti Saroso Hospital, Jakarta. Methods: A cross sectional study was conducted on adult patients in ICU and non-ICU wards who received intravenous albumin infusion at Sulianti Saroso hospital, between January 2013 to March 2018. Paired t-test was used to analyze the changes of albumin level before and after albumin infusion. Results: 123 ICU patients (41 sepsis, 82 non-sepsis) and 206 non-ICU patients (34 sepsis, 172 non-sepsis) who received 20% or 25% albumin infusions were included. Significant increase in albumin levels were observed in sepsis patients both in ICU and non-ICU, while in non-sepsis patients, the significant increase only observed in non-sepsis patients. Overall, mean increase in albumin levels in ICU-and non-ICU patients were 0.13 (0.63) g/dL vs 0.35(0.54) g/dL, respectively (P= < 0,001). Conclusion: Non-ICU patients show better response to albumin infusion compared to ICU patients. This difference is presumably due to different degree of inflammation. It is suggested that the quantity needed for albumin infusion is calculated differently according to clinical condition of the patients   
Clinical and Laboratory Characterization of Hemodialysis Patients in Relation to Survival Outcomes at a Tertiary Referral Hospital in Indonesia Sipayung, Elisabeth; Nariata, I Wayan; Yassir; Satyawati, Rumaisah; Wijaya, Surya Oto; Budi, Gesang Setia; Anitha; Rivaldiansyah; Maemun, Siti; Widiantari, Aninda Dinar
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.70810

Abstract

Introduction: Despite advancements in hemodialysis care, disease progression and outcomes in adults with various comorbidities, particularly in Indonesia’s overburdened tertiary hospitals, remain poorly characterized, limiting tailored care strategies. This study analyzed clinical characteristics and laboratory parameters among hemodialysis patients at Sulianti Saroso Infectious Disease Hospital, Jakarta, Indonesia, with stratification by survival outcomes. Methods: We conducted a retrospective cohort study of adults (>18 years) undergoing hemodialysis at Sulianti Saroso Infectious Disease Hospital between March and July 2024. Using purposive sampling, we analyzed 27 cases with documented laboratory parameters (i.e., blood urea nitrogen (BUN), serum creatinine, and estimated glomerular filtration rate (eGFR)) and clinical outcomes. Associations between outcomes and laboratory/clinical variables were assessed using Fisher’s exact test and logistic regression (p<0.05). Results: Mortality was reported in 25.9% of patients, including one who passed away due to complications related to coronavirus disease 2019 (COVID-19) shortly after being discharged. The leading indication for hemodialysis was hyperuricemia (85.2%), followed by chronic kidney disease. Nearly half of the patients (48.1%) had comorbid diabetes mellitus. Diabetic nephropathy was a key contributor to elevated urea levels. Prevalent complications reported among the patients included sepsis (70.4%) and glomerular disease (40.7%). Conclusion: This study found an association between diabetes mellitus and mortality in chronic kidney disease patients who underwent hemodialysis. Severe uremia, marked by elevated BUN levels, and symptomatic complications such as shortness of breath were observed, indicative of advanced disease progression. Earlier detection and optimized management are necessary to mitigate preventable morbidity in high-risk populations.   Highlights: 1. This study examined undercharacterized hemodialysis patients at an Indonesian tertiary hospital, focusing on high comorbidity burdens and outcomes. 2. Severe kidney disease and high mortality were observed, driven by comorbidities such as diabetes mellitus, hypertension, coronavirus disease 2019 (COVID-19), and infectious diseases (drug-resistant tuberculosis and hepatitis B/C). 3. The findings underscore the importance of optimized risk stratification and early intervention for end-stage renal failure in patients with both communicable and non-communicable disease comorbidities.
Co-Authors AA Sudharmawan, AA Anitha Budi, Gesang Setia Chandra Wijaya Iman Firmansyah Indriyati Indriyati Maemun, Siti MUHAMMAD TAUFIK Nafrialdi Nafrialdi Nariata, I Wayan Nina Mariana, Nina Rivaldiansyah Satyawati, Rumaisah Setyawati, Rumaisah Sipayung, Elisabeth Teguh Sarry Hartono, Teguh Sarry Widiantari, Aninda Dinar Yassir