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All Journal Dentika Dental Journal Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang
Gigih Andy Putra, Achmad
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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A Review of Mechanism of Action of Moringa oleifera as an Inhibitor of Adipogenesis in Obesity Gigih Andy Putra, Achmad; Louisa, Melva
Pharmaceutical Journal of Indonesia Vol. 9 No. 1 (2023)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2023.009.01.9

Abstract

Background: Obesity has been becoming a global health problem that could cause the emergence ofmany other diseases. Several strategies are used to treat obesity, including lifestyle modifications,anti-obesity medications (pharmacotherapy), bariatric surgery, and gut microbiota transplantation.Pharmacotherapy is an effective treatment method and is often chosen by obese people because it isquite simple and does not require invasive and expensive procedures. However, long-term usage ofconventional medicines causes serious side effects. Therefore, studies about herbal medicineincreased significantly, one of them is Moringa oleifera (MO). Objectives: This review providesinformation about the pathways involved in the adipogenesis processes in obesity and how MO caninhibit adipogenesis through several pathways. Methods: Data were collected from PubMed based onthe keywords “moringa”, “obese”, “adipogenesis”, “adipocyte”, and “lipogenesis”. There were 16journals in full text that met the inclusion criteria for conducting a literature study related to thesekeywords over the last 10 years (from 2013 to 2023). Results: The anti-obesity effect of MO isthought to come from several specific compounds isolated from this plant, including quercetin,isoquercetin, quercetin-3-O-malonylglucoside, astragalin, kaempferol, isothiocyanate, EGCG, andmany others. These active compounds can be isolated from various parts of the MO plant, but themost widely used are the leaves and seeds. These compounds exert anti-obesity activity by inhibitingadipogenesis through multiple pathways, including the AMPK, PI3K/AKT, MAPK, JAK/STAT,TGF-β, and Wnt/β-catenin pathways. Conclusions: Several in vivo, in vitro, and clinical trial studieshave been conducted to demonstrate the benefits and safety of MO as a medicinal plant withpharmacological potential to inhibit adipogenesis in obesity.Keywords: moringa; adipogenesis; adipocyte; lipogenesis; obese
A Review of Mechanism of Action of Moringa oleifera as an Inhibitor of Adipogenesis in Obesity Gigih Andy Putra, Achmad; Louisa, Melva
Pharmaceutical Journal of Indonesia Vol. 9 No. 1 (2023)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2023.009.01.9

Abstract

Background: Obesity has been becoming a global health problem that could cause the emergence ofmany other diseases. Several strategies are used to treat obesity, including lifestyle modifications,anti-obesity medications (pharmacotherapy), bariatric surgery, and gut microbiota transplantation.Pharmacotherapy is an effective treatment method and is often chosen by obese people because it isquite simple and does not require invasive and expensive procedures. However, long-term usage ofconventional medicines causes serious side effects. Therefore, studies about herbal medicineincreased significantly, one of them is Moringa oleifera (MO). Objectives: This review providesinformation about the pathways involved in the adipogenesis processes in obesity and how MO caninhibit adipogenesis through several pathways. Methods: Data were collected from PubMed based onthe keywords “moringa”, “obese”, “adipogenesis”, “adipocyte”, and “lipogenesis”. There were 16journals in full text that met the inclusion criteria for conducting a literature study related to thesekeywords over the last 10 years (from 2013 to 2023). Results: The anti-obesity effect of MO isthought to come from several specific compounds isolated from this plant, including quercetin,isoquercetin, quercetin-3-O-malonylglucoside, astragalin, kaempferol, isothiocyanate, EGCG, andmany others. These active compounds can be isolated from various parts of the MO plant, but themost widely used are the leaves and seeds. These compounds exert anti-obesity activity by inhibitingadipogenesis through multiple pathways, including the AMPK, PI3K/AKT, MAPK, JAK/STAT,TGF-β, and Wnt/β-catenin pathways. Conclusions: Several in vivo, in vitro, and clinical trial studieshave been conducted to demonstrate the benefits and safety of MO as a medicinal plant withpharmacological potential to inhibit adipogenesis in obesity.Keywords: moringa; adipogenesis; adipocyte; lipogenesis; obese
The role of Manalagi apple (Malus sylvestris Mill.) extract gel in fibronectin expression during traumatic ulcer healing Achmad Gigih Andy Putra; Nikmatus Sa'adah; Andre Geromiko Himang; Herlambang Prehananto; Sawitri Dwi Indah Pertami; Endah Kusumastuti; Agus Aan Adriansyah; Siti Aisyah Abd Ghafar
Dentika: Dental Journal Vol. 29 No. 1 (2026): Dentika: Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v29i1.24666

Abstract

Traumatic ulcer is open wound caused by injury to the oral mucosa. Fibronectin, a multifunctional glycoprotein, has been reported to play a crucial role in early wound healing by promoting fibroblast migration. Several studies have shown that Manalagi apple (Malus sylvestris Mill.) contains bioactive compounds with anti-inflammatory, antioxidant, antibacterial, and wound healing properties. Therefore, this study aims to evaluate the effect of Manalagi apple extract gel on fibronectin expression in traumatic ulcer healing. This was a laboratory experimental study with a post-test only control group design. A total of 10 rats (Rattus norvegicus) were randomly divided into a placebo gel control group and a treatment group receiving 10% Manalagi apple extract gel. Fibronectin expression was then evaluated using immunohistochemical (IHC) staining, and analyzed with the Mann–Whitney test. The results showed a significant difference in fibronectin expression between the treatment and control groups (p = 0.007). The application of 10% Manalagi apple extract gel significantly increased fibronectin expression during traumatic ulcer healing.
Co-Authors Agus Aan Adriansyah Andre Geromiko Himang Endah Kusumastuti Herlambang Prehananto Melva Louisa Nikmatus Sa'adah Sawitri Dwi Indah Pertami Siti Aisyah Abd Ghafar