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All Journal JURNAL FARMASIMED (JFM) Jurnal Indah Sains dan Klinis
Yosi Darmirani
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Dentistry Health Professions Medicine & Pharmacology Nursing

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ANTIBACTERIAL ACTIVITY TEST OF CELERY LEAF ETHANOL EXTRACT (APIUM GRAVEOLENS L.) AGAINST BACTERIA STREPTOCOCCUS SANGUINIS Pranata, Chandra; Renty Monica; Asti Pratiwi; Yosi Darmirani
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

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Abstract

Health is a very important part of human life, especially oral health. Diseases that occur due to lack of oral hygiene include gingivitis caused by Streptococcus sanguinis bacteria. Chlorhexidine is a solution that is used to clean the oral cavity and prevent plaque formation on the teeth. An alternative mouthwash that comes from nature is celery leaves (Apium graveolens L.) with secondary metabolites, namely alkaloids, flavonoids, saponins and tannins. This study was conducted to determine the antibacterial activity of celery leaf ethanol extract against Streptococcus sanguinis bacteria at concentrations of 12.5%, 25%, 50% and 100% using the disc diffusion method with chlorhexidine as a positive control and Aquadest as a negative control. The celery leaf extraction method was carried out by maceration method using 96% ethanol solvent. The results of the inhibition test with a concentration of 12.5%, 25%, 50% and 100% celery leaf ethanol extract can inhibit the growth of Streptococcus sanguinis bacteria with an average diameter of the inhibition zone in the negative control group (aquadest) is 0 mm, 12.5% concentration is 8.15 mm, at 25% concentration is 7.95 mm, 50% concentration is 9.05 mm, 100% concentration is 9.9 mm, while in chlorhexidine (positive control) an average of 17.83 mm is obtained. From these results, it can be concluded that there is activity of celery leaf ethanol extract against the growth of Streptococcus sanguinis bacteria with a concentration that effectively inhibits the growth of Streptococcus sanguinis bacteria is 100% concentration. Keywords: Celery Leaf, Gingivitis, Streptococcus sanguinis
Deteksi Antibakteri Fraksi Ekstrak Etanol Folium Sambung Nyawa (Gynura procumbens) pada Salmonella typhi Yosi Darmirani; Wibman Tambunan; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 4 No 3 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i3.02

Abstract

Background: Folium Sambung Nyawa, a native plant in Indonesia, is known for its abundant medicinal properties. Among its various secondary metabolites, flavonoids stand out, being polyphenolic compounds found in numerous plants and foods. Flavonoids exhibit a wide range of bioactive properties, including antibacterial, anti-inflammatory, anti-diabetic, anti-cancer, anti-ageing, and antioxidant effects. Objective: This study aimed to assess the antibacterial potential of Sambung Nyawa Leaf extract fractions against Salmonella typhi bacteria. Methods: The antibacterial activity was evaluated using the paper disc diffusion method to determine the inhibition zones. Three fractions---n-hexane, ethyl acetate, and water---were tested at concentrations of 10%, 20%, and 30% each, along with negative controls (DMSO) and positive controls (Chloramphenicol). Results: Flavonoid examination using synode reagent yielded positive results. Among the fractions tested, the 30% ethyl acetate fraction exhibited the most promising antibacterial activity, with an inhibition zone of 7.65 mm, indicating strong efficacy against Salmonella typhi bacteria. Conclusion: The findings suggest that the ethyl acetate fraction of the concentrated Sambung Nyawa leaf extract possesses potent antibacterial properties against Salmonella typhi bacteria
Formulation of Body Scrub Containing Ethanol Extract of Temulawak Rhizome (Curcuma xanthorrhiza Roxb) as a Skin Moisturizer H, Herlina; Melda Astrika Sianipar; Yaturramadhan Harahap, Hasni; Aritonang, Barita; Yosi Darmirani
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2650

Abstract

A body scrub is a cosmetic formulation intended to exfoliate dead skin cells and enhance skin hydration. One promising natural ingredient for body scrub formulations is the rhizome of Java turmeric (Curcuma xanthorrhiza Roxb.), which contains curcumin, a potent antioxidant known to support skin moisture retention. This study aims to evaluate the moisturizing efficacy of a body scrub formulated with Java turmeric rhizome extract. Methods: The rhizome was extracted through maceration using 96% ethanol and incorporated into body scrub formulations at concentrations of 10%, 15%, and 20%. The formulations were assessed for organoleptic characteristics, homogeneity, pH, spreadability, adhesion, oisturizing effect, and potential skin irritation on human volunteers. A commercial body scrub served as the comparator in a study involving 12 volunteers over four weeks, with applications performed once per week. Results: All Java turmeric body scrub formulations remained physically stable at room temperature and did not induce skin irritation. The physical characteristics of the formulations met standard cosmetic criteria, including consistent appearance, pH range of 6–7, spreadability between 5–7 cm, adhesion time above 4 seconds, and absence of irritation. Moisturizing effectiveness was evaluated using a skin analyzer, and data were statistically analyzed using SPSS. The p-value of 0.046 indicates that there is a significant difference between F1 and the commercial product, while for F2 and F3, there is no significant difference in moisturizing effectiveness between the temulawak formulations and the commercial product.. Among the tested formulations, the body scrub containing 20% Java turmeric extract exhibited the highest moisturizing effect. Conclusion: The body scrub formulated with Java turmeric rhizome extract, particularly at a concentration of 20%, is safe for use and shows potential as a natural moisturizing product comparable to commercial products on the market.
Co-Authors Aritonang, Barita Asti Pratiwi Debi Meilani Herlina H Melda Astrika Sianipar Pranata, Chandra Renty Monica Wibman Tambunan Yaturramadhan Harahap, Hasni