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All Journal JURNAL FARMASIMED (JFM) Jurnal Indah Sains dan Klinis Indonesian Journal of Social Science and Education
Asti Pratiwi
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Humanities Dentistry Education Health Professions Medicine & Pharmacology Nursing

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ANTIBACTERIAL ACTIVITY TEST OF CELERY LEAF ETHANOL EXTRACT (APIUM GRAVEOLENS L.) AGAINST BACTERIA STREPTOCOCCUS SANGUINIS Pranata, Chandra; Renty Monica; Asti Pratiwi; Yosi Darmirani
Jurnal FARMASIMED (JFM) Vol 6 No 1 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

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Abstract

Health is a very important part of human life, especially oral health. Diseases that occur due to lack of oral hygiene include gingivitis caused by Streptococcus sanguinis bacteria. Chlorhexidine is a solution that is used to clean the oral cavity and prevent plaque formation on the teeth. An alternative mouthwash that comes from nature is celery leaves (Apium graveolens L.) with secondary metabolites, namely alkaloids, flavonoids, saponins and tannins. This study was conducted to determine the antibacterial activity of celery leaf ethanol extract against Streptococcus sanguinis bacteria at concentrations of 12.5%, 25%, 50% and 100% using the disc diffusion method with chlorhexidine as a positive control and Aquadest as a negative control. The celery leaf extraction method was carried out by maceration method using 96% ethanol solvent. The results of the inhibition test with a concentration of 12.5%, 25%, 50% and 100% celery leaf ethanol extract can inhibit the growth of Streptococcus sanguinis bacteria with an average diameter of the inhibition zone in the negative control group (aquadest) is 0 mm, 12.5% concentration is 8.15 mm, at 25% concentration is 7.95 mm, 50% concentration is 9.05 mm, 100% concentration is 9.9 mm, while in chlorhexidine (positive control) an average of 17.83 mm is obtained. From these results, it can be concluded that there is activity of celery leaf ethanol extract against the growth of Streptococcus sanguinis bacteria with a concentration that effectively inhibits the growth of Streptococcus sanguinis bacteria is 100% concentration. Keywords: Celery Leaf, Gingivitis, Streptococcus sanguinis
Uji Aktivitas Ekstrak Biji Asam Jawa (Tamarindus indica) terhadap Asam Urat Mencit Putih Jantan (Mus Musculus) Induksi Kalium Oksonat Asti Pratiwi; Aminah Syarifuddin; Cucu Arum Dwi Cahya; Melinda Sari
Jurnal Indah Sains dan Klinis Vol 4 No 2 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i2.01

Abstract

Background: The Tropical Tamarind Plant has great economic value and benefits for society, from the stems to the leaves it can be used to treat diseases, such as fever, dyspepsia and even gonorrhoea. The chemical components of Tamarind seeds include alkaloids, saponins, flavonoids, glycosides, malic acid, tartrate, pectin, arabinose, xylose, galactose and glucose. Objective: The study was directed to determine the activity of ethanol extract from tamarind seeds in reducing uric acid in mice. Methods: Preparation of dry extract of Tamarind seeds (EKBAJ), phytochemical screening, and testing the activity of reducing uric acid in mice induced by potassium oxonate at various concentrations of EKBAJ. Measure the levels with Easy Touch GCU. Results: EKBAJ can inhibit mouse uric acid synthesis. The higher the concentration of EKBAJ, the greater the effect on reducing uric acid levels. Conclusion: A concentration of 200 mg/kgBW had the greatest effect on reducing uric acid in mice.
Kuantifikasi Vitamin C Petai Cina (Leucaena leucocephala) dengan Spektrofotometri UV-Vis Asti Pratiwi; Aminah Syarifuddin; Cucu Arum Dwi Cahya; Sri Rahayu
Jurnal Indah Sains dan Klinis Vol 4 No 3 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i3.01

Abstract

Background: Vitamin C is very soluble in water and is always used for additional nutrition in the form of supplements. This vitamin is needed by the body because it can increase the body's ability to fight disease and function as a neutralizer of radical particles found in the body, usually referred to as antioxidants. One of them is the Petai Cina plant which is used by the community as a savory flavor in dishes, and can also be used as traditional medicine. Objective: To determine the presence and levels of vitamin C in Petai Cina in the Lubuk Pakam regional market. with quality and quantity analysis. Method: Samples were analyzed qualitatively using a specific color reagent for vitamin C and quality was determined using UV spectrophotometry. Results: The standard vitamin C wavelength is 224.5 nm at a concentration of 4 ppm with the regression equation y = 0.0339x + 0.3922. Qualitatively, it is proven that there is vitamin C in Petai Cina with a quantity of 0.1095 mg/mL. Conclusion: Vitamin is found in Petai Cina with a quantity of 0.1095 circulating in the Lubuk Pakam market
The Effect of Giving Green Apple (Malus Domestica) Juice on the Histopathology of White Rat Pulmonary Organs Induced by Cigarette Smoke Pranata, Chandra; Asti Pratiwi
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2437

Abstract

Background: Cigarette smoke contains oxidants or free radicals and around 4700 dangerous chemicals. The high level of free radicals in the body triggers the emergence of Reactive Oxygen Species (ROS) which results in oxidative stress, this can occur if there is an imbalance between the amount of oxidants and antioxidants. In this process, there is a leak of O2 which will turn into superoxide radicals (*O2) which can form pro-inflammatory cytokines such as IL-6. Objective: to identify the effect of exposure to cigarette smoke on the histopathological appearance of rat lungs. Method: This research uses Post Test Only Control Group Design. Samples were taken from 20 male rats that met the inclusion criteria and were randomly divided into 4 groups, namely K1, K2, K3, and K4. K3 was given standard feed plus green apple juice at a dose of 13.5 grams/day. Meanwhile, the K4 group was given standard feed plus green apple juice at a dose of 27 grams/day. However, both were given exposure to cigarette smoke for 14 days. On the 15th day, blood was taken from male Wistar rats to carry out a histopathological examination of the rats' lungs using Hematoxillin-Eosin staining. Results: The results showed that there was damage in the negative group when compared with the normal group and the highest improvement in lung tissue was found at a dose of 27 grams/day when compared with the negative and normal groups. Conclusion: There is an effect of giving green apple juice on IL-6 and SOD levels in mice exposed to cigarette smoke.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PENGAMBILAN KEPUTUSAN CALON MITRA PRODUK ES TEH INDONESIA DI KOTA BANDUNG Asti Pratiwi; Wentri Merdiani
Indonesian Journal of Social Science and Education (IJOSSE) Vol. 1 No. 3 (2025): Vol. 1 No. 3 : Edisi September 2025
Publisher : JCI Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62567/ijosse.v1i3.1353

Abstract

Penelitian ini bertujuan mengetahui persepsi calon mitra terhadap faktor eksternal yang memengaruhi keputusan bergabung dengan Es Teh Indonesia, menyusun analisis SWOT, dan mengidentifikasi faktor eksternal dominan di Kota Bandung. Penelitian menggunakan metode kualitatif dengan pendekatan studi kasus. Data diperoleh melalui wawancara mendalam dengan calon mitra, mantan mitra, dan ahli bisnis, serta dokumen sekunder. Analisis data menggunakan pendekatan tematik serta triangulasi. Hasil penelitian menunjukkan bahwa faktor eksternal seperti lokasi strategis, daya beli konsumen, serta intensitas persaingan sangat memengaruhi keputusan calon mitra. Analisis SWOT menekankan kekuatan pada popularitas merek dan sistem waralaba terstruktur, dengan kelemahan ketergantungan pusat dan biaya royalti tinggi. Faktor eksternal dominan adalah kekuatan merek serta potensi pasar lokal Bandung yang masih terbuka.
Co-Authors Aminah Syarifuddin Cucu Arum Dwi Cahya Melinda Sari Pranata, Chandra Renty Monica SRI RAHAYU Wentri Merdiani Yosi Darmirani