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All Journal Science and Technology Indonesia Journal of Sustainable Economic and Business
Ihsan, Ikhwanul
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Materials Science & Nanotechnology Physics Social Sciences

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Ketoprofen-Tromethamine: Binary Phase Diagram of Multicomponent Crystal, Dissolution Rate, and Analgesic Activity Evaluation Hasanah, Uswatul; Badriyya, Elsa; Safitri, Reza; Yuliza, Sukma; Ihsan, Ikhwanul; Saafrida; Rosaini, Henni; Jessica, Adhitya; Zaini, Erizal
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.726-734

Abstract

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose formulation options are limited due to its low dissolution rate in aqueous media. This research aimed to enhance the solubility of ketoprofen in distilled water and to compare the anti-inflammatory and analgesic effects of its resulting multicomponent crystal with tromethamine. The binary phase diagram of ketoprofen-tromethamine was created across molar ratios ranging from 1:9 to 9:1. The multicomponent crystal comprising ketoprofen and tromethamine in the selected ratio was synthesized using a solvent drop grinding method and subjected to further characterization for thermal properties, crystallinity, chemical groups, and morphology. The dissolution rate assessments were evaluated in CO2-free distilled water. Pharmacological analyses examined the anti-inflammatory and analgesic effects of the multicomponent crystal. The binary phase analysis identified the 5:5 (1:1) molar ratio as optimal in forming a multicomponent crystal. Thermograms and diffractograms revealed crystalline alterations attributed to a new crystalline phase. The new multicomponent crystal exhibited approximately 2.7 times higher dissolution rate after 30 minutes, outperforming pure ketoprofen. Pharmacological assessments demonstrated superior analgesic effects of the multicomponent crystal. In summary, the ketoprofen-tromethamine cocrystal in 1:1 molar ratio offers enhanced dissolution rate and provides better analgesic activity than ketoprofen alone.
Analysis of Roof Tile Defective Products Using the Seven Tools Method in PT. XYZ Ihsan, Ikhwanul; Sugiyono, Sugiyono
Journal of Sustainable Economic and Business Vol. 2 No. 2 (2025): Journal of Sustainable Economic and Business (JOSEB)
Publisher : ARE Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70550/joseb.v2i2.52

Abstract

Objectives: This study aims to analyze and reduce the number of defective products produced by PT XYZ which is 3% per month. This research uses a quantitative descriptive method as a method used to find the root causes. The purpose of this study is to determine the number of defective products that occur, the factors that cause them, and provide recommendations for improvement to improve the quality of roof tile products. Methodology: This research uses the Seven Tools method which includes check sheets, histograms, control charts, pareto diagrams, and fishbone diagrams to identify and analyze the causes of defective roof tile products. Findings: Check sheets help in the collection and analysis of defect data. Stratification shows that the most common defect is Face Crack, which accounts for 39.01% of the total defects. Conclusion: The pareto diagram shows that Face Crack and Lap Fault are the two most dominant types of defects. The histogram shows that the total product defects are 113,138 for the Face Crack category. The control map shows that the dominant product defects are outside the control limits, indicating the need for improvements to the production process. The fishbone diagram identifies the factors affecting product defects are human, machine, environment, and material.  
Co-Authors Elsa Badriyya Erizal Zaini Jessica, Adhitya Reza Safitri Rosaini, Henni Saafrida Sugiyono Sugiyono Uswatul Hasanah, Uswatul Yuliza, Sukma