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Uji dan Karakterisasi Serbuk Pektin dari Albedo Durian sebagai Kandidat Eksipien Farmasi Patihul Husni; Uvita Kafilatul Ikhrom; Uswatul Hasanah
Majalah Farmasetika Vol 6, No 3 (2021): Vol. 6, No. 3, Tahun 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v6i3.33349

Pektin adalah senyawa polisakarida yang larut dalam air dan merupakan asam-asam pektinat yang mengandung gugus-gugus metoksil. Fungsi utamanya sebagai bahan pengental dan pembentuk gel. Durian (Durio zibethinus L.) merupakan buah yang memiliki aroma yang sangat khas dan banyak diminati masyarakat karena memiliki rasa enak dan aroma yang harum. Buah durian terdiri dari tiga bagian yaitu daging buah sekitar 20-35%, biji sekitar 5-15% sisanya berupa bobot kulit yang mencapai 60-75% dari bobot total buah. Bagian kulit buah durian yang dapat dimanfaatkan sebagai sumber pektin yaitu pada bagian kulit dalam durian yang berwarna putih yang disebut juga dengan mesocarp. Tujuan dari penelitian ini adalah untuk melakukan karakterisasi serbuk pektin albedo durian yang dihasilkan dan mengetahui kualitas serbuk eksipien pharmaceutical grade dari pektin albedo durian. Penelitian ini dilakukan dengan metode refluks menggunakan pelarut asam sulfat. Pada kondisi keasaman pelarut pH 2, pH 3, dan pH 4, waktu ekstraksi 5 jam dan pada suhu 90⁰C. Hasil penelitian menunjukkan bahwa karakteristik pektin pH 3 lebih memenuhi kriteria sebagai eksipien pharmaceutical grade karena laju alir yang paling baik yaitu 4,368 g/detik, kerapatan mampat 0,590 g/mL, kompresibilitas 11,802%, sudut diam 20,124⁰, susut pengeringan 10%, kadar Pb 7,075 bpj dan kadar abu 10,760%.

FORMULASI DAN UJI STABILITAS FISIK GRANUL INSTAN SERBUK KERING TANGKAI GENJER (Limnocharis flava (L.) Buchenau.) SEBAGAI SUPLEMEN PENAMBAH SERAT Patihul Husni; Muchamad Luthfi Fadhiilah; Uswatul Hasanah
Jurnal Ilmiah Farmasi Farmasyifa Vol 3, No 1 (2020)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v3i1.5163

Serat dibutuhkan dalam pencernaan adalah agar proses pencernaan dapat bekerja secara maksimal. Genjer (Limnocharis flava (L.) Buchenau.) merupakan tanaman yang bagian tangkainya banyak mengandung serat. Kandungan serat yang tinggi pada genjer terutama pada bagian tangkainya berpotensi untuk dikembangkan sebagai suplemen makanan penambah serat berupa granul instan. Tujuan penelitian ini adalah untuk mendapatkan formula terbaik granul instan secara fisik. Granul instan dibuat dengan metode granulasi basah menggunakan variasi konsentrasi PVP sebagai pengikat. Uji stabilitas fisik granul instan dilakukan pada suhu kamar selama satu bulan meliputi uji waktu alir, sudut diam, indeks kompresibilitas, kandungan lembab dan waktu larut. Hasil penelitian menunjukkan bahwa waktu alir granul 8-14 detik untuk 100 gram granul, sudut diam sekitar 40o, indeks kompresibilitas 11-15%, kandungan lembab sekitar 2% dan waktu larut 1-2 menit. Berdasarkan hasil uji stabilitas fisik, formula terbaik granul instan serbuk kering tangkai genjer adalah F2 dengan komposisi serbuk kering tangkai genjer 100 mg, laktosa 70%, PVP 3%, aspartam 1,5%, manitol 20%, Natrium Benzoat 0,5%, Green tea flavor 5% b/b dan etanol qs dengan total bobot granul 1000 mg.

PEMBENTUKAN MULTIKOMPONEN KRISTAL PIPERIN DAN KUERSETIN Adhitya Jessica; Rifka Naura; Uswatul Hasanah; Erizal Zaini; Lili Fitriani
JURNAL FARMASI DAN MAKANAN Vol 4 No 2 (2021): Journal Of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v4i2.1881

Penggunaan klinis piperin masih terbatas karena memiliki kelarutan rendah di dalam air. Kuersetin dikenal sebagai bioenhancer yang dapat meningkatkan bioavailibilitas senyawa lain. Penelitian ini bertujuan untuk meningkatkan kelarutan piperin dengan memodifikasinya menjadi bentuk multikomponen kristal bersama kuersetin. Pembentukan multikomponen kristal piperin-kuersetin dilakukan menggunakan metode solvent drop grinding (SDG). Multikomponen dikarakterisasi dengan Differential Scanning Calorimetry (DSC), Powders X-Ray Diffraction (PXRD) dan spektroskopi FTIR.Evaluasi multikomponen dilakukan dengan uji kelarutan dan hasilnya dianalisis menggunakan KCKT.Termogram DSC menunjukkan tidak adanya puncak endotermik baru yang berbeda nyata dari kedua komponen. Pola difraksi sinar-X multikomponen kristal piperin-kuersetin menunjukkan difraktogram yang serupa dengan komponen penyusun, yang mengindikasikan tidak terbentuknya fase kokristalin. Karakterisasi menggunakan FTIR menunjukkan hampir tidak ada pergeseran puncak serapan gugus fungsi piperin pada multikomponen kristal. Uji kelarutan dilakukan terhadap senyawa tunggal piperin, campuran fisik piperin-kuersetin dan multikomponen piperin-kuersetin (1:1) yang dibuat dengan metode SDG. Campuran fisik dan multikomponen piperin-kuersetin yang dibuat dengan metode SDG meningkatkan kelarutan piperin sebesar 1,475 kali lipat dan 1,389 kali lipat jika dibandingkan dengan piperin murni.

Formulation and evaluation of orally disintegrating film (ODF) containing piperine-succinic acid cocrystal Uswatul Hasanah; Lili Fitriani; Verlia Nisrina Putri; Erizal Zaini
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Piperine is a type of alkaloid found in plants of the Piperaceae family, including Piper nigrum and Piper longum, which has numerous pharmacological properties and is being developed as a nutraceutical. However, its poor solubility makes delivering in effective doses for therapeutic purposes challenging. To overcome this limitation, the cocrystals of piperine and succinic acid was prepared, which are more soluble, and then formulated into orally disintegrating films (ODFs) for better delivery. The cocrystals were formed using the slurry method, while the ODFs were made using the solvent-casting method with different concentrations of hydroxypropyl methylcellulose (HPMC) and polyethylene glycol (PEG) 400. The resulting films were evaluated for various parameters, such as their organoleptic characteristics, weight and thickness uniformity, pH, moisture content, swelling properties, and disintegration time. The results showed that the ODF with 6% HPMC as a film-forming polymer and 0.6% PEG 400 as a plasticizer loaded with 10 mg of piperine in the form of piperine-succinic acid cocrystal was the best formula. This ODF formulation disintegrated in less than one minute and was found to be a good film with uniform content.

FORMULASI DAN UJI STABILITAS FISIK SEDIAAN LOTION EKSTRAK KERING KULIT KAYU MANIS (Cinnamomum burmannii) Patihul Husni; Yuni Ruspriyani; Uswatul Hasanah
Jurnal Sabdariffarma Vol 10, No 1 (2022): SABDARIFFARMA
Publisher : Prodi Farmasi - Universitas Al Ghifari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53675/jsfar.v10i1.396

Pemakaian produk topikal yang mengandung antioksidan merupakan salah satu cara untuk mencegah kerusakan kulit karena antioksidan dapat mencegah efek radikal bebas. Kulit kayu manis (Cinnamomum burmannii) mengandung senyawa antioksidan. Penelitian ini bertujuan untuk menentukan formula terbaik sediaan lotion mengandung ekstrak kering kulit kayu manis. Sediaan lotion dibuat menggunakan metode safonifikasi. Lotion dibuat dalam tiga formula dengan perbedaan konsentrasi trietanolamin. Uji stabilitas fisik (organoleptis, pH, viskositas), uji iritasi dan uji kesukaan dilakukan untuk menentukan formula terbaik. Hasil penelitian menunjukkan bahwa sediaan lotion memiliki warna coklat, kental, bau khas, homogen dengan viskositas dan pH yang memenuhi persyaratan serta tidak mengiritasi kulit. Semua formula lotion tetap stabil setelah desman selama 1 bulan pada suhu kamar. Formula terbaik berdasarkan uji stabilitas fisik dan uji kesukaan adalah F1.

Enhancing Gambir's Economic Value from Processing to Bath Soap Raw Materials: Community Service Program Uswatul Hasanah; Nova Syafni; Adhitya Jessica; Erizal Zaini; Rini Agustin
Warta Pengabdian Andalas Vol 31 No 2 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.2.277-284.2024

Gambir, an extract derived from the leaves and branches of the gambir plant, holds significant potential for enhancing the local economy and its benefits as a cosmetics product. Jorong Balai Tampuak Pinang, Nagari Simpang Kapuak, Kecamatan Mungka, was one of the areas producing traditional gambir in Lima Puluh Kota district, West Sumatra, Indonesia. This community service initiative aimed to augment the economic value of gambir from its processing to raw materials of bath soap. The initiative began with an educational session for training participants, outlining the advantages of gambir in skincare and how to incorporate it into bath soap formulations. Following the learning session, participants actively produced gambir-contained bath soap utilizing the provided formula. The activity received favorable feedback from participants who appreciated enhancing knowledge and skills. The outcomes of this endeavor underscore the substantial potential of developing body care products utilizing gambir as a primary ingredient. Participant testimonials underscore the need to conduct similar community engagement activities to harness Gambir's further utilization of other personal care products. The collaboration between the pharmacy study program and the local community has opened new avenues for local economic development and sustainable growth, significantly impacting the local population's well-being in the region.

Body Mist-Making Training and Socialization of Cosmetic Product Registration and Marketing Authorization to Youth Organisations in Kerinci Nova Syafni; Try Andy Sahputra; Saafrida Saafrida; Uswatul Hasanah; Rini Agustin; Rahmi Yosmar; Friardi Ismed; Erizal Zaini
Warta Pengabdian Andalas Vol 31 No 2 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.2.336-342.2024

Indonesia is an important country that produces essential oils that are widely used in fragrance cosmetic products. The use of local essential oils for cosmetics needs to be introduced to the youth generation with the aim that they do not just become consumers. Youth organisations in Kerinci have many activities to improve their skills and abilities for a better future. Collaboration between the university and the youth organisation was achieved by providing training on doing cosmetic product training on making cosmetic products. The product uses essential oils called body mist. Nowadays, the youth still know very little about the manufacturing process of cosmetics products. To provide further benefits, this community service activity collaborated with BBPOM in Padang, West Sumatra, to explain cosmetic safety and the registration process of cosmetic products. With this series topic in this training and outreach-related cosmetics, it is hoped that it can increase business ideas for young people who are members of the Sakti Alam Kerinci Organisation.

Utilization of Gambier Leaves as Foot Lotion for Diabetics to Increase Community Income in The Limau Manis, Village, Padang, West Sumatra: Pemanfatan Daun Gambir Sebagai Lotion Kaki Pada Penderita Diabetes Untuk Meningkatkan Pendapatan Masyarakat di Kelurahan Limau Manis, Padang, Sumatera Barat Suci Nasution, Embun; Fajar Putra, Adika; Hasanah, Uswatul
Jukeshum: Jurnal Pengabdian Masyarakat Vol. 5 No. 1 (2025): Edisi Januari 2025
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/jukeshum.v5i1.1109

Limau Manis is one of the villages located on Jalan Bandes, Pauh subdistrict, Padang city, West Sumatra province, Indonesia. Limau Manis village has a special problem, namely the lack of health training and the utilization of natural herbs of West Sumatra, namely gambier. This community service aims to provide education on the branding of the pharmacist, diabetes and its prevention, the use of gambier as diabetic’s foot lotion and workshops to make the product, marketing and business plans of a product. This community service conducted on July 12, 2024 with a modified Community Based Interactive Approach (CBIA) method. This activity is divided into 3 stages, namely the pre-implementation stage, the implementation stage, and the monitoring and evaluation stage. The diabetes’s foot lotion formula consists of gambier leaf extract, stearic acid, cera alba, nipagin, nipasol, paraffin liquid, glycerin, triethanolamine, corrigen odoris, and aquadest. Stability tests conducted on diabetes foot lotion for 6 cycles included organoleptic test, homogeneity test, pH test, spreadability test, and adhesion test. The result, distinctive aroma, brownish yellow color, and creamy shape, homogeneous, pH is 6.1 with spreadability 5.2-7 cm and the adhesion test >1 second. It no irritation on the hands of volunteers and met the requirements of the moisture test. The participants were representatives of farmers, housewives, Integrated Healthcare Center staff, youth organizations, and the community actively who were involved during the activity. The comunnity service using the CBA method can increase participans’ knowledge and skill by 77% obtain from pre-test and post-test.

Enhancing Gambir's Economic Value from Processing to Bath Soap Raw Materials: Community Service Program Uswatul Hasanah; Nova Syafni; Adhitya Jessica; Erizal Zaini; Rini Agustin
Warta Pengabdian Andalas Vol 31 No 2 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.2.277-284.2024

Gambir, an extract derived from the leaves and branches of the gambir plant, holds significant potential for enhancing the local economy and its benefits as a cosmetics product. Jorong Balai Tampuak Pinang, Nagari Simpang Kapuak, Kecamatan Mungka, was one of the areas producing traditional gambir in Lima Puluh Kota district, West Sumatra, Indonesia. This community service initiative aimed to augment the economic value of gambir from its processing to raw materials of bath soap. The initiative began with an educational session for training participants, outlining the advantages of gambir in skincare and how to incorporate it into bath soap formulations. Following the learning session, participants actively produced gambir-contained bath soap utilizing the provided formula. The activity received favorable feedback from participants who appreciated enhancing knowledge and skills. The outcomes of this endeavor underscore the substantial potential of developing body care products utilizing gambir as a primary ingredient. Participant testimonials underscore the need to conduct similar community engagement activities to harness Gambir's further utilization of other personal care products. The collaboration between the pharmacy study program and the local community has opened new avenues for local economic development and sustainable growth, significantly impacting the local population's well-being in the region.

Body Mist-Making Training and Socialization of Cosmetic Product Registration and Marketing Authorization to Youth Organisations in Kerinci Nova Syafni; Try Andy Sahputra; Saafrida Saafrida; Uswatul Hasanah; Rini Agustin; Rahmi Yosmar; Friardi Ismed; Erizal Zaini
Warta Pengabdian Andalas Vol 31 No 2 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.2.336-342.2024

Indonesia is an important country that produces essential oils that are widely used in fragrance cosmetic products. The use of local essential oils for cosmetics needs to be introduced to the youth generation with the aim that they do not just become consumers. Youth organisations in Kerinci have many activities to improve their skills and abilities for a better future. Collaboration between the university and the youth organisation was achieved by providing training on doing cosmetic product training on making cosmetic products. The product uses essential oils called body mist. Nowadays, the youth still know very little about the manufacturing process of cosmetics products. To provide further benefits, this community service activity collaborated with BBPOM in Padang, West Sumatra, to explain cosmetic safety and the registration process of cosmetic products. With this series topic in this training and outreach-related cosmetics, it is hoped that it can increase business ideas for young people who are members of the Sakti Alam Kerinci Organisation.

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