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Arif, Maria Nisaul
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Potential of gambier leaf ethanol extract cream for incised wound healing Arif, Maria Nisaul; Lumbantobing, Christina J. R. Esmaralda; Chiuman, Linda
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4403

Abstract

Incised wounds are highly susceptible to bacterial infection, which requires stimulation of healing and restoration of normal function of the injured body part. This study aimed to test the effect of gambier leaf ethanol extract cream administration on the acceleration of wound healing on the skin surface of male Wistar rats. The research used a pre-test post-test with a control group design. Twenty male white rats were divided into four groups: control group (P0), treatment group 1 (P1), treatment 2 (P2), and treatment 3 (P3). The incision wounds in white rats were treated twice a day (in the morning and evening) for 14 days. Wound healing was observed by measuring the average length of the wound every day, from the first day of wounding until day 14. Statistical tests used were one-way ANOVA and post-hoc LSD test (p < 0.05). In this study, it was found that the 15% gambier leaf extract cream was more effective in wound healing in white rats than the 5% and 7.5% gambier leaf extract creams. However, in the group treated with 7.5% gambier leaf extract cream, the situation was already close to that in the treatment group treated with 15% gambier leaf extract cream. This is because, at a concentration of 7.5%, the secondary metabolite compounds in the gambier leaf extract had an effect on wounds, but at a concentration of 15% gambier leaf extract cream, the effect was similar to that of 15% gambier leaf extract cream.
Test The Activity Of Administering Ethanol Extract Cream From Gambier Leaves (Uncaria Gambir Raxb) To Accelerate The Healing Of Incision Wounds On The Surface Of The Skin Of Male Wistar Strain Rats (Rattus Norvegicus) Arif, Maria Nisaul; Amansyah , Adek; Suhartina, Suhartina
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Wound healing, especially incisions, is still a problem in the health sector due to the many cases and treatment approaches used during globalization. This research tested whether ethanol extract cream from gambier leaves (Uncaria Gambir Raxb) could accelerate the healing of skin wounds in male Wistar rats. Pre-test and post-test with control group design were used in this laboratory experiment. In this study, the acceleration of healing was the dependent variable. Meanwhile, gambier leaf extract cream is an independent variable in the laboratory of the Faculty of Mathematics and Natural Sciences, University of North Sumatra. The research process has several stages: Rat acclimatization, Gambir Leaf Extract and Cream Formula, White Rat Incisions, Histopathological Observations, and Data Processing. SPSS 22 analyzes research data. Shapiro-Wilk determined data normality. One-way ANOVA calculated group mean differences for well-distributed data (P > 0.05). The Post Hockey (HSD) test detected significant treatment differences (P 0.05). The Kruskal-Walli test is used for irregular data. In white mice, 15% gambier leaf extract cream healed cuts better than 5% and 7.5%. However, gambier leaf extract cream 7.5% has a performance like 15%. At a concentration of 7.5%, secondary metabolite compounds from gambier leaf extract heal wounds, while low concentrations suppress bacteria, making them less effective. Thus, gambier leaf extract contains antioxidant phytochemicals that can be used as medicine.
Co-Authors Amansyah , Adek Chiuman, Linda Lumbantobing, Christina J. R. Esmaralda Suhartina Suhartina, Suhartina