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All Journal Medicinus : Jurnal Kedokteran Health Information : Jurnal Penelitian
Manubulu, Charles Pauris
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Efek Kurkumin Terhadap Stres Oksidatif Dan Profil Metabolik Pasien Sindrom Ovarium Polikistik Christiani, Christiani; Manubulu, Charles Pauris; Arimas, Eka
Health Information : Jurnal Penelitian Content Digitized
Publisher : Poltekkes Kemenkes Kendari

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Abstract

Sindrom Ovarium Polikistik (PCOS) menjadi penyakit endokrin yang paling sering dikeluhkan oleh wanita usia reproduktif. Perjalanan penyakit PCOS bersifat multifaktorial, namun, dua proses penting yang mempengaruhi perkembangan PCOS yaitu stres oksidatif dan hiperlipidemia. Komplikasi dari PCOS seperti infertilitas menjadi akibat dari terapi yang hingga kini belum kunjung ditemukan untuk mengatasi kondisi tersebut. Intervensi yang telah dicoba untuk mengatasi PCOS memiliki berbagai efek samping yang mempengaruhi kondisi pasien. Oleh sebab itu, suatu terobosan baru diperlukan untuk mengatasi PCOS. Senyawa fitokimia yaitu kurkumin dipandang memiliki potensi dalam tatalaksana PCOS. Efek antioksidan dan pengaturan lipid dapat menjadi terobosan baru untuk mengatasi PCOS. Metode: Pencarian jurnal dilakukan melalui beberapa database penelitian antara lain Google Scholar, PubMed, dan Wiley. Kata kunci yang digunakan adalah “kurkumin”, “stres oksidatif”, “profil metabolik” dan “PCOS”. Hasil: Pencarian literatur menghasilkan 1.772 jurnal dengan 39 jurnal sesuai dengan kriteria. Studi yang diprioritaskan merupakan studi yang diterbitkan Kami memprioritaskan penelitian yang diterbitkan dalam jangka waktu lima tahun terakhir. Simpulan: Berbagai studi telah membuktikan efektivitas kurkumin dalam mengubah proses patofisologi stres oksidatif dan hiperlipidemia pasien PCOS. Selain itu, pemanfaatan dan pengguaan kurkumin di Indonesia cukup mudah dijangkau. Pemberian kurkumin dapat direkomendasikan pada pasien PCOS secara luas dan efisien.
Recent Therapies for Endometriosis: A Systematic Review Putra, Ananda; Winata, Raymond Malvin; Berlianzsa, El-Varel Baby; Chandra, Angelica Isabella Monica; Manubulu, Charles Pauris; Tarigan, Tiara Namora; Ellyamurti, Devanti Octavia; Firdaus, Najmarani Devi; Risdiana, Dilla Alfinda
Medicinus Vol. 13 No. 1 (2023): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v13i1.10779

Abstract

Background: Endometriosis is a chronic gynecological disorder characterized by the growth of endometrial tissue outside the uterine cavity. It commonly affects women of reproductive age and is associated with chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility. The disease significantly impacts productivity, social functioning, and sexual health, making it one of the leading causes of disability and reduced quality of life among women. Methods: This review was conducted through a literature search using databases such as PubMed, ScienceDirect, Google Scholar, and ResearchGate. Articles published between 2016 and 2025 were selected using the keywords endometriosis, hormonal therapy, and non-hormonal therapy. Relevant studies were analyzed, cross-referenced, and evaluated to identify current therapeutic strategies for endometriosis management. Result: The management of endometriosis currently includes both hormonal and non-hormonal therapies. Hormonal treatments involve the use of aromatase inhibitors, gonadotropin-releasing hormone (GnRH) analogues, selective estrogen receptor modulators (SERMs), selective progesterone receptor modulators (SPRMs), and dienogest, all aimed at suppressing estrogen production and endometrial growth. Non-hormonal therapies, on the other hand, utilize anti-inflammatory, anti-angiogenic, and pro-apoptotic mechanisms to target the inflammatory cascade that contributes to the pathogenesis of endometriosis. These therapies aim to reduce chronic inflammation, cell proliferation, and pain without interfering with ovulation or fertility. Conclusions: Both hormonal and non-hormonal therapies play a crucial role in managing endometriosis. While hormonal therapy remains the mainstay of treatment, non-hormonal approaches show promising results with fewer side effects and greater patient tolerability. However, further clinical studies are required to evaluate their long-term efficacy and safety before they can be widely implemented in clinical settings.
Co-Authors Arimas, Eka Berlianzsa, El-Varel Baby Chandra, Angelica Isabella Monica Christiani, Christiani Ellyamurti, Devanti Octavia Firdaus, Najmarani Devi Putra, Ananda Risdiana, Dilla Alfinda Tarigan, Tiara Namora Winata, Raymond Malvin