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All Journal International Journal of Public Health Excellence (IJPHE) Cermin Dunia Kedokteran
Putra, Aulia Wiratama
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Health Professions Medicine & Pharmacology Nursing Public Health

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Enhancement Risk Disease Cardiovascular in Children with Hypospadias Putra, Aulia Wiratama; Prayuda, Yoga Eka; Suherman, Levita Dyah Kartika; Ratu, Tiffani; Cahyono, Ari Harto
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 1 (2023): June-December
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i1.627

Abstract

Hypospadias is a congenital disorder in boys due to low fetal androgen hormones. Hypospadias is one of the congenital disorders with the highest prevalence. Several studies have revealed the association of hypospadias with cardiovascular disease. There are still very few studies that summarize cardiovascular manifestations in pediatric hypospadias. Therefore, this study was designed to describe the cardiovascular risk in pediatric patients with hypospadias. Method : Journal searches were carried out through several research databases including Google Scholar, PubMed, and Sciencedirect . The keywords used were "hypospadias", "cardiovascular", and "pediatric". The results of the literature search were 1,543 journals with 20 journals meeting the criteria. Results and Discussion : Hypospadias is one of the second most common congenital abnormalities in men after testicular undescensus . Children born with hypospadias are proven to experience changes in vascular structure, namely increased carotid intima media thickness (CMIT) and are associated with hypertension. Hypospadias patients have impaired endothelial function, decreased vasorelaxation, and increased vasoreactivity. The underlying mechanism is a Rho kinase and ROS dependent process. Conclusion: Children with hypospadias have a higher risk of cardiovascular disease.
Enhancement Risk Disease Cardiovascular in Children with Hypospadias Putra, Aulia Wiratama; Prayuda, Yoga Eka; Suherman, Levita Dyah Kartika; Ratu, Tiffani; Cahyono, Ari Harto
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 1 (2023): June-December
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i1.627

Abstract

Hypospadias is a congenital disorder in boys due to low fetal androgen hormones. Hypospadias is one of the congenital disorders with the highest prevalence. Several studies have revealed the association of hypospadias with cardiovascular disease. There are still very few studies that summarize cardiovascular manifestations in pediatric hypospadias. Therefore, this study was designed to describe the cardiovascular risk in pediatric patients with hypospadias. Method : Journal searches were carried out through several research databases including Google Scholar, PubMed, and Sciencedirect . The keywords used were "hypospadias", "cardiovascular", and "pediatric". The results of the literature search were 1,543 journals with 20 journals meeting the criteria. Results and Discussion : Hypospadias is one of the second most common congenital abnormalities in men after testicular undescensus . Children born with hypospadias are proven to experience changes in vascular structure, namely increased carotid intima media thickness (CMIT) and are associated with hypertension. Hypospadias patients have impaired endothelial function, decreased vasorelaxation, and increased vasoreactivity. The underlying mechanism is a Rho kinase and ROS dependent process. Conclusion: Children with hypospadias have a higher risk of cardiovascular disease.
Gangguan Kognitif Pasca-Stroke – Tinjauan Sistematik: Analisis Pradhea, Tifani Antonia; Dwikarlina, Intan; Putra, Aulia Wiratama; Agustina, Lisa; Nardian, Derajat Fauzan
Cermin Dunia Kedokteran Vol 51 No 12 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i12.1239

Abstract

Introduction: The increasing number of stroke survivors was accompanied by an increase of cognitive impairment incidence as one of the post-stroke long-term consequences. Post-stroke cognitive impairment needs to be highlighted because of impact on reducing the quality of life, especially in the elderly. Methods: Literature was extensively searched across ScienceDirect, PubMed, Google Scholar, and Cochrane databases, using several predetermined keywords. Results and Discussion: Nine articles were analyzed. MMSE and MoCA assessments were used as parameters of post-stroke cognitive impairment. Most patients experience post-stroke cognitive impairment ranging from mild cognitive impairment to vascular dementia or other types of dementia. Risk factors include older age, female, lower and shorter education, location of lesions in the left hemisphere with involvement of certain brain structures, uncontrolled and fluctuating blood pressure, family history of stroke, comorbid diseases, as well as an individualistic social life. Conclusion: Stroke significantly increases the risk of cognitive impairment anddementia.
Co-Authors Cahyono, Ari Harto Dwikarlina, Intan Lisa Agustina, Lisa Nardian, Derajat Fauzan Pradhea, Tifani Antonia Prayuda, Yoga Eka Ratu, Tiffani Suherman, Levita Dyah Kartika