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All Journal MASALIQ: Jurnal Pendidikan dan Sains Gudang Jurnal Multidisiplin Ilmu
Najla Dhifa Tofanny
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Religion Aerospace Engineering Arts Humanities Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Public Health Social Sciences Other

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Pembuatan Virgin Coconut Oil (VCO) Menggunakan Metode Penggaraman Dengan NaCl Najla Dhifa Tofanny; Olga Tiara Rizki; Khalisa; Sisri Wartati; Desy Kurniawati; Arif Juliari Kusnanda
Gudang Jurnal Multidisiplin Ilmu Vol. 2 No. 6 (2024): GJMI - JUNI
Publisher : PT. Gudang Pustaka Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59435/gjmi.v2i6.660

Abstract

Virgin Coconut Oil (VCO) merupakan produk minyak kelapa murni yang proses pembuatannya tidak melibatkan proses pemanasan dan pengerjaannya pun sangat sederhana. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan garam NaCl terhadap hasil dan kualitas VCO. Hasil dari penelitian pada penambahan NaCl berbau minyak kelapa segar sesuai dengan ketentuan SNI. Pada uji bilangan asam didapatkan bahwa hasil analisis bilangan asam sebesar 0,11% pada minyak VCO kontrol maupun dengan penambahan NaCl. Kesimpulan pada perconaan ini diperoleh pada uji organoleptik didapat perbedaan yg signifikan dari kedua variasi, pada uji bilangan asam diperoleh hasil yang sama sebesar 0,11% dan untuk uji terakhir volume dari vco penggaraman lebih banyak dibandingan dengan kontrol.
Potensi Anti-Inflamasi Senyawa Crotalaria Medicaginea terhadap COX-2: Studi In Silico Najla Dhifa Tofanny; Fitri Amelia
MASALIQ Vol 6 No 1 (2026): JANUARI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i1.8955

Abstract

This study was motivated by the limited number of in silico investigations examining the anti-inflammatory potential of bioactive compounds from Crotalaria medicaginea Lamk, despite the fact that inflammation is a pathological condition largely mediated by the cyclooxygenase-2 (COX-2) enzyme. The study aimed to analyze the potential interactions and binding affinities of bioactive compounds from Crotalaria medicaginea Lamk toward COX-2 as an anti-inflammatory target. A computational research design was employed using an in silico molecular docking approach. The research samples comprised the COX-2 enzyme structure obtained from the Protein Data Bank and bioactive compounds identified from the phytochemical data of Crotalaria medicaginea Lamk. Data were generated through ligand and protein preparation and subsequently analyzed using docking software to determine binding energy values and interaction patterns of amino acid residues at the active site of the enzyme. The results showed that one of the bioactive compounds exhibited stable binding affinity and was able to form interactions at the COX-2 active site, thereby supporting the theory that COX-2 inhibition can attenuate inflammatory responses. The study concludes that the bioactive compounds of Crotalaria medicaginea Lamk have the potential to be developed as anti-inflammatory candidates, with theoretical implications for enriching the literature on the use of medicinal plants based on in silico studies and practical implications as a basis for developing natural anti-inflammatory drugs. This research also opens up opportunities for further in vitro and in vivo studies to confirm the computational findings.
Co-Authors Arif Juliari Kusnanda DESY KURNIAWATI Fitri Amelia Khalisa Olga Tiara Rizki Sisri Wartati