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All Journal Jurnal EduHealth PharmaCine : Journal of Pharmacy, Medical and Health Science
Elyyana, Nina
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Aktivitas Farmakologi Daun Jambu Biji (Psidium guajava L) sebagai Agen Antidiare Elyyana, Nina; Oktavianti, Alfina; Alfiyah, Mutiara; Advaita, Chalisya Vanya; Ryandha, Mochamad Galuh
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol 3 No 1 (2022): PharmaCine : Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v3i1.7237

Abstract

Latar Belakang: Diare merupakan suatu masalah kesehatan yang menyebabkan angka kematian yang besar di Indonesia. Di indonesia prevalensi kasus diare terjadi peningkatan di setiap tahunnya. Diare dapat terjadi di semua kalangan baik anak balita maupun lanjut usia (lasia). Pengobatan diare dapat di lakukan secara herbal atau tradisional menggunakan dau jambu biji. Tujuan: Maka dari itu, Review artikel ini bertujuan untuk mengetahui potensi daun jambu biji sebagai antidiare. Metode: Metode yang di gunakan dalam review artikel ini yaitu studi literatur dengan mengumpulkan data eklusi maupun inklusi yang terkait manfaat dari daun jambu biji sebagai antidiare. Uji khasiat daun jambu biji sebagai antidiare dilakukan dengan pemberian ekstrak daun jambu biji pada sapi bali. Hasil: Didapatkan bahwa daun jambu biji mengandung beberapa bahan aktif antara lain tanin, flavonoid, guajaverin, leukosianidin, minyak atsiri, asam malat, damar, dan asam oksalat, tetapi hanya komponen khusus seperti flavonoid, tanin, minyak atsiri, dan alkaloid yang memiliki efek farmakologi sebagai antidiare. Kata Kunci : Antidiare, Diare, Daun Jambu Biji
Literature Review : Study of molecular mechanism level of NSAID class of drugs as COX-2 inhibitors Zakiyah, Wildani; Sukma Wibowo, Sepvia Putri; Elyyana, Nina; Nur Darmawan, Shiyami Aulia; Lestari, Sepiyani Ayu; Sa'diyyah, Nur; Malau, Jekmal; Mulki, Munir Alinu
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.745 KB)

Abstract

NSAIDs (Non-Steroid Anti-Inflammatory Drugs) are drugs that can treat pain and inflammation. The therapeutic effect of NSAIDs as anti-inflammatory analgesics is that they have the ability to inhibit the biosynthesis of prostaglandins which are pain mediators. This prostaglandin has a major role in inhibiting the COX enzyme (cyclooxygenase) in which COX has two isoforms, namely COX1 isoenzyme (non-selective) and COX2 isoenzyme (selective). Tricyclic COX-2 selective inhibitors work by blocking COX-2. COX-2 binds to PD-L1 via the PGE2 pathway and affects macrophages in suppressing myeloid. COX-2 has functions including producing reactive oxygen species that are responsible for DNA damage, activating substances that deviate from intracellular pathways such as the MAPK and PI3 K/AKT pathways, activating STAT3, inducing Bcl-2, and producing growth factors including growth factors. epidermal (EGF)) and fibroblast growth factor (FGF).
Co-Authors Advaita, Chalisya Vanya Alfiyah, Mutiara Jekmal Malau Lestari, Sepiyani Ayu Munir Alinu Mulki Nur Darmawan, Shiyami Aulia Oktavianti, Alfina Ryandha, Mochamad Galuh Sa'diyyah, Nur Sukma Wibowo, Sepvia Putri Zakiyah, Wildani