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All Journal Jurnal EduHealth PharmaCine : Journal of Pharmacy, Medical and Health Science
Zakiyah, Wildani
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Efektivitas Senyawa Antioksidan dalam Saffron (Crocus Sativus L) Zakiyah, Wildani; Fauziah, Anisa; Farikha, Siti; Nurlaela, Nurlaela; Sakina, Irene Virda; Saula, Lely Sulfiani
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol 2 No 1 (2021): PharmaCine : Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v2i1.5579

Abstract

Crocus sativus L atau dikenal di masyarakat sebagai saffron atau kuma-kuma yang berasal dari marga crocus dengan famili iridaceae. Kandungan utama di dalam saffron yaitu Crocin, Crocetin, Picrococin, dan safranal yang memiliki khasiat sebagai anti kanker, anti inflamasi, dan anti artritis. Kandungan antioksidan yang ada pada saffron diantaranya adalah senyawa fenolik dan karotenoid. Metode yang digunakan dalam pembuatan review artikel ini adalah pengumpulan literatur dari sumber jurnal yang ada yang berkaitan dengan safron (Crocus Sativus L), dimana pencarian literature jurnal yang bersumber dari Google, google scholar, libgen, dan pubmed. Pengujian antioksidan saffron menggunakan sel A549, crocin, dimethylcrocetin, crocetin, dan crocin. Selain iu ada pula apocarotenoid, cocetin, safranal. Eksrak saffron secara in vitro diuji dengan konsentrasi 200-2000 microgram/ml dapat menurunkan viabilitas sel MCF-7 dengan dosis waktu IC50 400 +/- 18,5 mikrog / ml setelah 48 jam.
Metode Pemisahan Fitokimia Tanin pada Tanaman Herbal Indonesia Zakiyah, Wildani; Agustin, Annastya Eka; Fauziah, Anisa; Maharani, Dhavina; Mukti, Galih Ibnu
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol 2 No 1 (2021): PharmaCine : Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v2i1.5582

Abstract

Pemisahan kimia adalah cara untuk memisahkan bagian tertentu dari suatu campuran. Pemisahan fitokimia secara umum sistematisnya adalah pembuatan simplisia, skrining, ekstraksi, fraksinasi, isolasi, dan identifikasi senyawa. Penelitian ini bertujuan untuk mengetahui tahapan pemisahan yang cocok terhadap senyawa tannin yang cenderung polar, baik tannin terkondensasi atau proantosianidin maupun tannin terhidrolisis. Metode penelitian ini dengan melakukan penelusuran terhadap beberapa literatur jurnal ilmiah yang telah terpublikasi sebagai acuan penulisan. Hasil penelitian menunjukkan bahwa pada sejumlah tanaman yang dijadikan sampel terbukti memiliki kandungan tannin. Hal ini dilakukan melalui beberapa metode pemisahan yang efektif yakni, fraksinasi berupa ECC atau kromatografi, isolasi berupa KLT atau KLTP, serta pengidentifikasian senyawa melalui Spektrofotometer UV-VIS dan FTIR.
Article Review: Analysis Of Artificial Sweetness In Food And Beverages: English Zakiyah, Wildani; Nurul Sa'adah, Cantika; Prasetyo, Fajar; Febiola Lubis, Christina; Lina Nurfadhila; Marsah Rahmawati Utami
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.02 KB)

Abstract

Artificial sweeteners are substances added to food and beverages with the aim of giving a sweet taste, having no nutritional value. The types of artificial sweeteners allowed by the Minister of Health are Cyclamate, Saccharin, Aspartame and Sorbitol. The method used in this paper is a literature review study. The total journals used in this article review are 14 journals. In several studies, the levels of artificial sweeteners contained in related foods are still within the limits permitted by the government, but in some studies there are still foods whose levels of artificial sweeteners exceed the permitted limits.
Literature Review : Study of molecular mechanism level of NSAID class of drugs as COX-2 inhibitors Zakiyah, Wildani; Sukma Wibowo, Sepvia Putri; Elyyana, Nina; Nur Darmawan, Shiyami Aulia; Lestari, Sepiyani Ayu; Sa'diyyah, Nur; Malau, Jekmal; Mulki, Munir Alinu
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.745 KB)

Abstract

NSAIDs (Non-Steroid Anti-Inflammatory Drugs) are drugs that can treat pain and inflammation. The therapeutic effect of NSAIDs as anti-inflammatory analgesics is that they have the ability to inhibit the biosynthesis of prostaglandins which are pain mediators. This prostaglandin has a major role in inhibiting the COX enzyme (cyclooxygenase) in which COX has two isoforms, namely COX1 isoenzyme (non-selective) and COX2 isoenzyme (selective). Tricyclic COX-2 selective inhibitors work by blocking COX-2. COX-2 binds to PD-L1 via the PGE2 pathway and affects macrophages in suppressing myeloid. COX-2 has functions including producing reactive oxygen species that are responsible for DNA damage, activating substances that deviate from intracellular pathways such as the MAPK and PI3 K/AKT pathways, activating STAT3, inducing Bcl-2, and producing growth factors including growth factors. epidermal (EGF)) and fibroblast growth factor (FGF).
Co-Authors Agustin, Annastya Eka Elyyana, Nina Farikha, Siti Fauziah, Anisa Febiola Lubis, Christina Jekmal Malau Lestari, Sepiyani Ayu Lina Nurfadhila Maharani, Dhavina Marsah Rahmawati Utami Mukti, Galih Ibnu Munir Alinu Mulki Nur Darmawan, Shiyami Aulia NURLAELA NURLAELA Nurul Sa'adah, Cantika Prasetyo, Fajar Sa'diyyah, Nur Sakina, Irene Virda Saula, Lely Sulfiani Sukma Wibowo, Sepvia Putri