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All Journal INFOKUM Eduvest - Journal of Universal Studies
Wiwis Wijayanti, Christina Destri
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Aerospace Engineering Computer Science & IT Health Professions Neuroscience Social Sciences

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CORRELATION OF VITAMIN D WITH ANTIBODY QUANTITY IN IMMUNOPROPHYLACTIC INDIVIDUALS Wiwis Wijayanti, Christina Destri; Ekawati, Evy Ratnasari; Pradana, Muhammad Sungging
INFOKUM Vol. 10 No. 5 (2022): December, Computer and Communication
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/infokum.v10i5.1208

Abstract

The development of the field of health technology that integrates with advances in the economic field has provided an increase in life expectancy in populations in various countries today, but it is a life expectancy. this longer has its own effect in the form of an increase in cases of chronic diseases The preventive measures of a disease provide an individual's ability to stay healthy, happy and able to do activities freely. Immunoprophylactic is a powerful strategy in the primary prevention of a disease. The application of vaccination as an immunoprophylactic part is able to provide a protective effect related to the production of antibodies. The purpose of this study was to find out how the role of vitamin D is related to the formation of antibodies in individuals who have been vaccinated. The results showed that most of the study subjects had vitamin D levels within normal limits and to determine the formation of antibodies obtained the presence of production antibodies in each study subject using the immunofluorescent antibody detection method. Test the proximity of the relationship between the two variables using pearson correlation test from 25 research data. The pearson correlation test showed significance p=0.704 where p>0.05 indicated the absence of correlation between the assessed variables. The effect of vitamin D on immune cells, especially those related to the process of producing antibodies is very complex where the possibility of tolerogenic influence is one of the influencing factors. Vitamin D receptors are known to be mostly expressed by immune cells but there are differences in control related to cell activity status, for example vitamin D receptors can decrease in when differentiation occurs into macrophage cells or dendritic cells. The conclusions of the study showed that the concentration of vitamin D in most of the study subjects has not had a significant effect on the immunity system assessed based on the detection of levels antibodies.
Analysis of Complete Blood Count (Cbc) and Erythrocyte Sedimentation Rate (Esr) Results in Multidrug Resistant Tuberculosis (Mdr-Tb) Patients Wiwis Wijayanti, Christina Destri; Herawati , Dheasy; Annisa Juniati, Annisa
Eduvest - Journal of Universal Studies Vol. 4 No. 6 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i6.1350

Abstract

Tuberculosis (TB) is a contagious infectious disease caused by the bacterium M. tuberculosis. The emergence of drug-resistant strains of Mycobacterium tuberculosis causing MDR-TB is one of the public health problems to date. Globally, it is estimated that there will be 450,000 incident cases of MDR-TB in 2021, up 3.1% from 437,000. The danger of side effects that can arise in tuberculosis patients during MDR-TB treatment is that one of them is a decrease in the number of erythrocytes, the number of leukocytes and platelets. The purpose of this study was to analyze the results of Complete Blood Count (CBC) and ESR in Multidrug Resitant Tuberculosis (MDR-TB) patients at the University Hospital of Muhammadiyah Malang. This study is an observational descriptive study with data sourced from primary data collection. The samples of this study were positive MDR-TB patients from TB-RO clinic of RSU Universitas Muhammadiyah Malang as many as 25 samples, examined in October-November 2023, male and female. The data were analyzed descriptively using tables and graphs. The results of the study averaged more than 50% in the components of hemoglobin, hematocrit, and erythrocyte count decreased. In the platelet count examination component, 32% on average decreased. The average leukocyte count component of 92% tends to be normal. The examination of ESR is not specific for MDR-TB patients, namely the female gender has increased (elongated) while the male gender tends to be normal.
Prevention of Iron Deficiency Anemia Through Blood Immunochemical Detection in Improving the Quality of Life of Elderly Wiwis Wijayanti, Christina Destri; Herawati, Dheasy; Mandasari, Andita Ayu; Mawarti, Herin
Eduvest - Journal of Universal Studies Vol. 5 No. 11 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i11.52272

Abstract

The increase in the elderly population poses challenges to health services in Indonesia, particularly regarding degenerative diseases and malnutrition due to reduced physical activity and dietary changes. Supporting the Asta Cita program for elderly assistance, it is essential to monitor elderly health to maintain wellness and functionality in old age. This study used descriptive analytical observation on 25 women aged 55 to 75 years. Results showed that hemoglobin levels declined below the normal range of 12–15 g/dL. Serum iron levels and lactate dehydrogenase (LDH) enzyme activity were measured using a spectrophotometer to assess anemia potential, while immune status was evaluated through vitamin D levels by immunofluorescence. Statistical analysis with SPSS software using Spearman’s correlation test revealed no significant relationships between hemoglobin and serum iron (p = 0.520), hemoglobin and LDH (p = 0.615), or serum iron with LDH (p = 0.543) and vitamin D (p = 0.138). Pearson correlation showed no association between hemoglobin and vitamin D (p = 0.885). These findings indicate weak or no correlation among these parameters in this sample. Factors such as small sample size and measurement limitations suggest that using more precise biomarkers, like Ferritin levels, could improve future research. This study contributes to understanding Prevention of Iron Deficiency Anemia Through Blood Immunochemical Detection in Improving the Quality of Life of Elderly—a valuable approach to elderly health monitoring.
Co-Authors Andita Ayu Mandasari, Andita Ayu Annisa Juniati, Annisa Ekawati, Evy Ratnasari Herawati , Dheasy Herawati, Dheasy Herin Mawarti Pradana, Muhammad Sungging