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All Journal Biota Jurnal SainHealth Justek : Jurnal Sains Dan Teknologi INFOKUM Jurnal Ar Ro'is Mandalika (Armada)
Pradana, Muhammad Sungging
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology

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CORRELATION OF VITAMIN D WITH ANTIBODY QUANTITY IN IMMUNOPROPHYLACTIC INDIVIDUALS Wiwis Wijayanti, Christina Destri; Ekawati, Evy Ratnasari; Pradana, Muhammad Sungging
INFOKUM Vol. 10 No. 5 (2022): December, Computer and Communication
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/infokum.v10i5.1208

Abstract

The development of the field of health technology that integrates with advances in the economic field has provided an increase in life expectancy in populations in various countries today, but it is a life expectancy. this longer has its own effect in the form of an increase in cases of chronic diseases The preventive measures of a disease provide an individual's ability to stay healthy, happy and able to do activities freely. Immunoprophylactic is a powerful strategy in the primary prevention of a disease. The application of vaccination as an immunoprophylactic part is able to provide a protective effect related to the production of antibodies. The purpose of this study was to find out how the role of vitamin D is related to the formation of antibodies in individuals who have been vaccinated. The results showed that most of the study subjects had vitamin D levels within normal limits and to determine the formation of antibodies obtained the presence of production antibodies in each study subject using the immunofluorescent antibody detection method. Test the proximity of the relationship between the two variables using pearson correlation test from 25 research data. The pearson correlation test showed significance p=0.704 where p>0.05 indicated the absence of correlation between the assessed variables. The effect of vitamin D on immune cells, especially those related to the process of producing antibodies is very complex where the possibility of tolerogenic influence is one of the influencing factors. Vitamin D receptors are known to be mostly expressed by immune cells but there are differences in control related to cell activity status, for example vitamin D receptors can decrease in when differentiation occurs into macrophage cells or dendritic cells. The conclusions of the study showed that the concentration of vitamin D in most of the study subjects has not had a significant effect on the immunity system assessed based on the detection of levels antibodies.
Study of the Efficacy of Different Concentrations of Alcohol-Based Hand Sanitizer in Preventing Pathogen Transmission Through Palms Ekawati, Evy Ratnasari; Santoso, Setyo Dwi; Pradana, Muhammad Sungging; Santoso, Andreas Putro Ragil; Hanum, Mufida; Khoir, Intan Wahyunillah Zaidah; Arifina, Rosyidatul
Biota Vol 10 No 2 (2024): Jurnal Biota 2024
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/biota.v10i2.23231

Abstract

An integral part of the human body is the hands, which most frequently come into contact with various items; they can be an intermediary for spreading infections from hands to food and potentially eaten by humans. Maintaining hand hygiene is the right strategy to avoid this spread, which includes using an alcohol-based hand sanitizer. This study examines the potential for varying concentrations of alcohol-based hand sanitizer to transmit pathogens through the palms. The form of research is a laboratory experiment with an appropriate research design. Test the antibacterial potential of variations in alcohol-based hand sanitizer concentrations of 40, 50, 60, 70, and 70% using well diffusion and dilution methods. The tests were done in quadruplicates. The test bacteria used are Escherichia coli, Enterotoxigenic Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus. The results of the research showed that of the four variations in the concentration of alcohol-based hand sanitizer, the bacteriostatic ability against Salmonella typhimurium, Pseudomonas aeruginosa, and Klebsiella pneumoniae bacteria was at a concentration of 40% to 80%. The bactericidal activity at a concentration of 80% was demonstrated by Escherichia coli, Enterotoxigenic Escherichia coli, and Staphylococcus aureus. Bactericidal activity was demonstrated against Escherichia coli, Enterotoxigenic Escherichia coli, and Staphylococcus aureus at an 80% concentration.
KOMBINASI UJI LARVASIDA EKSTRAK DAUN BELUNTAS (Pluchea indica linn) DAN BAWANG PUTIH (Allium Sativum) DALAM MEMBUNUH LARVA Aedes aegypti: COMBINATION OF LARVACIDE TEST OF BELUNTAS LEAF EXTRACT (Pluchea indica linn) AND GARLIC (Allium Sativum) IN KILLING Aedes aegypti LARVAE Hariyanti, Firda Natasya; Chamid, Abdul; Prasetya, Indra Adi Wira; Suryani, Elsa Mega; Pradana, Muhammad Sungging
Jurnal SainHealth Vol. 8 No. 2 (2024): September 2024
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Aedes aegypti is a type of mosquito that causes dengeu hemorrhagic fever as the main carrier (primary vector) of dengeu virus. This disease is very common in Indonesia, efforts to eradicate mosquito larvae are relatively cheap, simple by means of public health counseling and eradication of mosquito nests using insecticides. The purpose of this study was to determine the effectiveness of the combination of beluntas leaf extract (Pluchea indica linn) and garlic (Allium satisum) in killing Aedes aegypti mosquito larvae at concentrations of 10%, 20%, 50%, and 100% for 24 hours. This type of study used experimental research with a research sample of 400 Aedes aegypti mosquito larvae. The results showed that the combination of beluntas leaf extract (Pluche indica linn) and garlic (Allium satisum) has effectiveness as a larvicide of Aedes aegypti instar III. The effective concentration on the combination of beluntas leaf extract (Pluchea indica linn) and garlic (Allium sativum) is 50% within 24 hours.
Uji Potensi Antibakteri Ekstrak Kulit Jeruk Nipis Citrus aurantifolia (Christm) Swingle Terhadap Vibrio sp. Prasetya, Indra Adi Wira; Aziz, Aziz; Ekawati, Evy Ratnasari; Pradana, Muhammad Sungging; Batati, Nadiah Al; Pratiwi, Esti Rizkiana
Jurnal SainHealth Vol. 7 No. 1 (2023): Maret 2023
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v7i1.6731.9-14

Abstract

Lime (Citrus aurantifolia) is one of the herbal plants that is rich in benefits, especially as a herbal medicines. Besides of lime fruit, lime peel also has antibacterial properties such as essential oils which contain flavonoids which can inhibit bacterial growth. This research utilizes lime peel which will be extracted as a test material. The purpose of this research is to determine the antibacterial potential of lime peel extract against Vibrio sp. at various concentrations. This research used the well-diffusion method using MHA as a test medium to determine whether lime peel extract can inhibit the growth of Vibrio sp. Various concentrations and penicillin as a positive control used in this research to determine which concentration has a greatest potential for inhibiting the growth of Vibrio sp. Result of this study used qualitative analysis by comparing the clear zone size produced on the medium. The obtained result shown that 20%, 40%, 60%, 80% and 100% concentration of lime peel can forming a clear zone which mean they can inhibit the growth of  Vibrio sp. The best concentration used to inhibit Vibrio sp. is 100% concentration which produce 23.7 mm clear zone on MHA medium. Lime peel extract can be used to inhibit Vibrio sp. growth based on the research result.
Pengaruh Kombinasi Ekstrak Daun Biduri dan Daun Saga pada Penurunan Kadar Kolesterol Mencit Hiperkolesterolemia Munandar, David Khalik Arrafi; Pradana, Muhammad Sungging; Ngibad, Khoirul
Justek : Jurnal Sains dan Teknologi Vol 8, No 2 (2025): Juni
Publisher : Unversitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/justek.v8i2.31362

Abstract

Abstract: Hyperlipidemia is a disorder marked by elevated levels of lipids in the blood, often resulting from excessive dietary fat intake. Biduri and saga leaves are known for their antihyperlipidemic properties. This research aimed to evaluate the effect of a combination of ethanol extracts from biduri (Calotropis gigantea L.) and saga (Adenanthera pavonina L.) leaves in reducing cholesterol levels in hypercholesterolemic mice. The study was conducted using mice divided into six groups: a negative control group without treatment, a positive control group administered propylthiouracil (PTU), a drug control group treated with simvastatin as a standard, and three treatment groups receiving extract combinations in ratios of 1:1, 1:2, and 2:1 at doses of 14 mg/g BW, 28 mg/g BW, and 56 mg/g BW. Cholesterol levels were measured using the spectrophotometry method. The findings demonstrated that the ethanol extract combination effectively reduced cholesterol levels and exhibited potential as a natural antihyperlipidemic agent. The most effective reduction was observed at a dose of 59.80 mg/g BW with a 1:1 ratio. These results suggest that the combination of these plant extracts could serve as a promising herbal alternative for managing hypercholesterolemia and lay the groundwork for further development of safe and accessible herbal medicines.Abstrak: Hiperlipidemia adalah gangguan yang ditandai dengan meningkatnya kadar lemak dalam darah, yang umumnya disebabkan oleh konsumsi lemak secara berlebihan. Daun biduri dan daun saga dikenal memiliki aktivitas sebagai agen penurun lipid. Penelitian ini bertujuan untuk mengkaji pengaruh kombinasi ekstrak etanol daun biduri (Calotropis gigantea L.) dan daun saga (Adenanthera pavonina L.) terhadap penurunan kadar kolesterol pada mencit yang mengalami hiperkolesterolemia. Penelitian dilakukan dengan membagi mencit ke dalam enam kelompok, yaitu kontrol negatif tanpa perlakuan, kontrol positif yang diberikan propiltiourasil (PTU), kontrol obat dengan simvastatin sebagai pembanding, serta tiga kelompok perlakuan yang menerima kombinasi ekstrak dengan rasio 1:1, 1:2, dan 2:1 pada dosis 14 mg/g BB, 28 mg/g BB, dan 56 mg/g BB. Pengukuran kadar kolesterol dilakukan menggunakan metode spektrofotometri. Hasil menunjukkan bahwa kombinasi ekstrak etanol daun biduri dan daun saga mampu menurunkan kadar kolesterol secara signifikan dan memiliki potensi sebagai agen antihiperlipidemik alami. Penurunan paling optimal dicapai pada dosis 59,80 mg/g BB dengan rasio 1:1. Kombinasi ini berpotensi menjadi alternatif pengobatan herbal yang lebih aman dan terjangkau bagi masyarakat, serta menjadi dasar dalam pengembangan fitofarmaka berbasis kombinasi tanaman.
Study of Secondary Metabolites of Azolla Microphylla as Candidates for Aedes Aegypti Mosquito Repellents Pradana, Muhammad Sungging; Ekawati, Evy Ratnasari; Yusmiati, Siti Nur Husnul
Jurnal Ar Ro'is Mandalika (Armada) Vol. 5 No. 2 (2025): JURNAL AR RO'IS MANDALIKA (ARMADA)
Publisher : Institut Penelitian dan Pengembangan Mandalika Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59613/armada.v5i2.4958

Abstract

Dengue fever (DHF) is a disease that becomes an epidemic in an area every year. Prevention of the spread of DHF has been widely carried out as well as for vector bites. The use of repellent as one way to protect humans from mosquito bites. Alternative to the use of chemicals through the use of plants to repel mosquitoes need to be introduced. Mosquito repellents using plant-based ingredients have the advantage of being easily decomposed in nature. The aim of this study is to determine the content of secondary metabolites that can be used as mosquito repellents through multilevel extraction and to test the effectiveness of secondary metabolite content on the repellent power of Aedes aegypti mosquitoes. This study is an experimental study using 3 types of solvents with different levels of polarity. The results of the study obtained were positive for flavonoids with ethyl acetate solvent, positive for tepenoids and tannins with ethanol solvent. The positive compounds from the Azolla extract have the potential to repel mosquitoes.
IDENTIFIKASI TELUR SOIL TRANSMITTED HELMINT (STH) PADA TANAH PERSAWAHAN DI DESA SUKODONO MENGGUNAKAN METODE NATIF Suryani, Elsa Mega; Sunarko, Yuli Novianti; Pradana, Muhammad Sungging; Santoso, Setyo Dwi; Batati, Nadiah Al
Jurnal SainHealth Vol. 7 No. 2 (2023): September 2023
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v7i2.14356.73-78

Abstract

Soil is a mineral material that has several unconsolidated forms which are located on the surface of the earth and have undergone several treatments. Soil-Transmitted Helminth (STH) is an intestinal nematode that in its life cycle requires a soil medium for the infective form to mature. worms are moist soil, shady, and protected from sunlight. This study aims to determine whether there is contamination of "Soil-Transmitted Helminth" eggs and what species are present in the rice fields using the Native method. This examination uses a 2% eosin solution. The sample uses paddy fields in Sukodono Village. Sampling at 3 sampling points with 3 types of samples, the total sample is 9 samples of paddy soil. The research was conducted on April 26-28 2021 at the Parasitology Laboratory, Faculty of Health Sciences, Maarif Hasyim Latif University, Sidoarjo, on 9 samples of paddy soil, the results obtained were 3 types of samples, or 33% of the soil contaminated with worm eggs and 6 types of samples or 66% not contaminated with worm eggs. Keywords: Paddy fields, Soil Transmitted Helminth, Native Method
UJI EFEKTIVITAS REBUSAN DAUN KAYU JAWA (Lannea coromandelica) SEBAGAI INSEKTISIDA Aedes aegypti: BOILED KAYU JAWA LEAVES (Lannea coromandelica) EFFECTIVENESS AS Aedes aegypti INSECTICIDE Pradana, Muhammad Sungging; Karimah, Sulis Tiani; Herawati, Dheasy
Jurnal SainHealth Vol. 8 No. 1 (2024): Maret 2024
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v8i1.16527.25-30

Abstract

Aedes aegypti is a vector of Dengue Hemorrhagic Fever (DHF). DHF is transmitted through the bite of the Aedes aegypti mosquito which carries the virus in its body. Mosquito eradication can use natural insecticides derived from natural agent such as plants metabolites that are toxic to insects. Kayu Jawa leaf (Lannea coromandelica) is a wild plant that is easy to find. Kayu jawa leaves contain secondary metabolites such as saponins, flavonoids, polyphenols and tannins which has insecticide activity. This research was an experimental test using kayu jawa leaves (L. coromandelica) decoction at 20%, 40%, 60% and 100% to eradicate A. aegypti. Test results show that 100 % concentration of L. coromandelica leaves decoction has the greatest activity to eradicate A. aegypti. The lowest activity shown in 20% concentration. This is due to the performance of secondary metabolite compounds from L. coromandelica leaves. The conclusion of this research is L. coromandelica has an activity as an A. aegyti insecticides.
Co-Authors Andreas Putro Ragil Santoso, Andreas Putro Ragil Arifina, Rosyidatul Aziz Aziz Batati, Nadiah Al Chamid, Abdul Ekawati, Evy Ratnasari Hanum, Mufida Hariyanti, Firda Natasya Herawati, Dheasy Karimah, Sulis Tiani Khoir, Intan Wahyunillah Zaidah Munandar, David Khalik Arrafi Ngibad, Khoirul Prasetya, Indra Adi Wira Pratiwi, Esti Rizkiana Santoso, Setyo Dwi Sunarko, Yuli Novianti Suryani, Elsa Mega Wiwis Wijayanti, Christina Destri Yusmiati, Siti Nur Husnul