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All Journal Journal of Multidisciplinary Science: MIKAILALSYS Asian Journal of Science, Technology, Engineering, and Art African Multidisciplinary Journal of Sciences and Artificial Intelligence Open Access DRIVERset African Journal of Biochemistry and Molecular Biology Research Open Access DRIVERset African Journal of Sciences and Traditional Medicine Open Access DRIVERset Kwaghe International Journal of Sciences and Technology Open Access DRIVERset African Journal of Clinical Medicine and Pharmacy Research African Journal of Medicine, Surgery and Public Health Research
Tansaba, Akafa Andes
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Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Hypoglycaemic Potential of Methanol Stem-Bark Extract of Mangifera Indica in Alloxan Induced Diabetic Albino Rats and Its Toxicity Effect to Liver and Kidney Umaru, Isaac John; Ekubnse, Nkiri Annasthesia; Umaru, Kerenhappuch Isaac; Tansaba, Akafa Andes; Ugoeze, Egeonu Stephen; Nanmar, Chakfa
African Journal of Sciences and Traditional Medicine Vol 1 No 1 (2024): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v1i1.3358

Abstract

Mangifera indica (MI), popularly known as mango belong to the genus Mangifera and family Anacardiacea. The leaves, stem bark and roots are used as herbal medicines worldwide. Mango possesses anti-diabetic, anti-bacterial, anti- oxidant, anti-viral and anti-inflammatory properties. This research focuses on the hyperglycemic and antibacterial capacity of methanol stem bark extract of Mango tree in alloxan induced diabetic albino rats to combat its fatal consequences in humans. This work is carried out to determine the hypoglycemic capacity of methanol stem bark extract of Mangifera indica in alloxan-induced diabetic albino rats at different volumes (ml) of administration, to also determine the antibacterial capacity of methanol stem bark extract of Mangifera indica in alloxan-induced diabetic albino rats at different volumes (ml) of administration and to test the efficacy of methanol stem bark extract of Mangifera indica in alloxan-induced diabetic albino rats. Fresh stem bark (trunk) of Mangifera indica were collected in the Federal University Wukari school premises, were air dried for 21 days, pounded into powder, cold macerated in methanol, filtered and extract was gotten. 27 diseased-free (healthy) albino rats which were purchased at Yola, Adamawa State, were kept in different cages to enable proper analysis at the cause of the work. Results of liver function indices showed that treatments with 100 mg/kg, 200mg/kg and 400mg/kg body weight of Mangifera indica stem bark methanolic extract were able to restore liver function parameters at different levels of concentrations. Treatments with standard drug and all the doses of the extract were able to counteract the elevated effect of alloxan in some kidney parameters such as serum urea level at 200mg/kg with (25.23±1.98a) and (1.05 ±0.14a) for creatinine at 200mg/kg respectively. The result of this study shows that the stem back extract possessed as an agent for hypoglycaemic. These can serve as possible source of raw material for pharmaceutical products. However, the extract is found not to be harmful to the liver and kidney and should be used as health remedy for certain diseases such as hyperglycaemic and bacterial effects.
Antibacterial and Antifungal Potential of Methanol Stem–Bark Extract of Mangifera Indica Umaru, Kerenhappuch Isaac; Tansaba, Akafa Andes; Ugoeze, Egeonu Stephen; Nanmar, Chakfa; Umaru, Isaac John
African Journal of Sciences and Traditional Medicine Vol 1 No 1 (2024): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v1i1.3360

Abstract

Medicinal plants have served through the ages, as a constant source of medicaments for the exposure of variety of diseases. The history of herbal medicine is as old as human civilization. The plants are known to provide a rich source of botanical anthelmintic, antibacterial and insecticides. Mangifera indica (MI), popularly known as mango belong to the genus Mangifera and family Anacardiacea. The leaves, stem bark and roots are used as herbal medicines worldwide. In antibacterial analysis, higher growth inhibition rate was observed at 400 ug/ml for Klebsiella pneumonia with 20.55 + 1.26μg/mL indicating that the extract has effect at a higher concentration than when treated at a lower concentration. In blood glucose level analysis, administration of 100 mg/kg body weight of Mangifera indica stem bark methanolic extract showed reduced blood glucose level in day 14 with 5.11 ± 0.14a of treatment when compared to normal control.
Effects of Methanol Stem Bark Extract of Annona senegalensis on Kidney Function and Lipid Profile in Diethyl Nitrosamine-Induced Hepatocellular Carcinoma in Rats Umaru, Isaac John; Abbas, Khalid Yahuza; Omolara, Mosugu Ovayoza; Ekunyi, Agbo Chibuike; Ikira, Usman; Okang, Ogar Fonne; Akem, Ingwu Joseph; Tansaba, Akafa Andes; Frank, Otashu Kenneth; Philip, Shadrach
African Journal of Sciences and Traditional Medicine Vol 2 No 3 (2025): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v2i3.7358

Abstract

Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide, with high morbidity and mortality. This study evaluated the anticancer properties of Annona senegalensis stem bark extract in N-diethylnitrosamine (DEN)-induced hepatocellular carcinoma in Wistar rats. Liver carcinogenesis was induced in groups II–VI by intraperitoneal injection of DEN (50 mg/kg body weight in DMSO) once weekly for three weeks. Group II served as the negative control, while group III was the positive control (treated with silymarin, 100 mg/kg b.w.). Groups IV, V, and VI received ethanol extracts of A. senegalensis at 200, 400, and 600 mg/kg b.w., respectively, administered orally for 14 days. Treatment with the extract significantly (p < 0.05) reduced blood urea and creatinine levels, improved electrolyte balance, and enhanced liver histoarchitecture. The extract also favorably modulated lipid metabolism, lowering cholesterol levels from 368.57 ± 1.72 in the negative control to 251.31 ± 1.10 at 400 mg/kg, while increasing HDL levels from 96.21 ± 1.23 to 233.13 ± 0.86 at 600 mg/kg. These results suggest a cardioprotective role via improved lipid profiles. Additionally, kidney function was improved, as reflected by reduced urea (17.30 ± 0.85) and creatinine (2.67 ± 0.23) compared to negative controls (34.53 ± 0.70 and 3.72 ± 0.45, respectively). Overall, the ethanol extract of A. senegalensis demonstrated hepatoprotective, nephroprotective, and lipid-regulating effects, highlighting its potential as a therapeutic agent for mitigating DEN-induced HCC and its associated metabolic complications.
Co-Authors Abbas, Khalid Yahuza Absalom, Augustine Adamu, Usman Lukman Akem, Ingwu Joseph Chisom, Gabriel Favour Danjuma, Tyem Lawal David, Bando Christopher Efongwa, Emmanuel Ekubnse, Nkiri Annasthesia Ekunyi, Agbo Chibuike Frank, Otashu Kenneth Galam, Nanyak Zingfa Ikira, Usman Mona, Etah Hope Nanmar, Chakfa Okang, Ogar Fonne Omolara, Mosugu Ovayoza Onyinyechi, Nwachukwu Favour Philemon, Panah Philip, Shadrach Rebecca, Tsokwa Punarimam Udoh, Mary Athanasius Ugbedeojo, Sule John Ugoeze, Egeonu Stephen Umar, Kerenhappuch Isaac Umaru, Isaac John Umaru, Kerenhappuch Isaac