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All Journal Journal of Multidisciplinary Science: MIKAILALSYS Asian Journal of Science, Technology, Engineering, and Art African Multidisciplinary Journal of Sciences and Artificial Intelligence Open Access DRIVERset African Journal of Biochemistry and Molecular Biology Research Open Access DRIVERset African Journal of Sciences and Traditional Medicine Open Access DRIVERset Kwaghe International Journal of Sciences and Technology Open Access DRIVERset African Journal of Clinical Medicine and Pharmacy Research African Journal of Medicine, Surgery and Public Health Research
Tansaba, Akafa Andes
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Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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 1 
Effect of Mangifera Indica Root Methanolic Extract on Streptozotocin Induced Diabetic Albino Rats Umaru, Kerenhappuch Isaac; Tansaba, Akafa Andes; Nanmar, Chakfa; Umaru, Isaac John; Ugoeze, Egeonu Stephen
Kwaghe International Journal of Sciences and Technology Vol 1 No 1 (2024): Kwaghe International Journal of Sciences and Technology
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/kijst.v1i1.3397

Abstract

The growing prevalence of diabetes in both developed and developing nations has prompted scientists to intensify their research efforts in identifying potent therapeutic compounds from natural sources. These compounds are aimed at more effectively treating and managing diabetes. The aim of this research is to determine the potentials of Mangifera Indica on induced hyperglycemic rats. The materials and methods : The roots will be cut into small pieces, air-dried and 100g of the root powdered soaked , extracted in rotary evaporator, fort albino rats is used. Diabetes will be induced in rats by injecting them intraperitoneally (i.p.) with freshly prepared streptozotocin (STZ) dissolved in citrate buffer (0.1 M pH 4.5) after an overnight fast and Hyperglycemia confirmed. Thirty albino rats is randomly divided into six groups, each consisting of five rats: group 1-6. Group 1-3 control groups, NC (Normal non-treated control), DM (Negative control rats), PC (Positive Control) group 4-6 (Mangifera indica treated diabetic rats). The NC and DM (control groups) will be given distilled water, while the MI and DM + MI (experimental groups) will receive Mangifera indica extract at a dose of 100, 200 and 400 mg/kg/b.wt. Results: Day one blood glucose levels was lowered significantly (p < 0.05). Day three treatments with standard drug and 100 mg/kg body weight extract lowered blood glucose significantly (p < 0.05) close to normal after induction with alloxan. The results of selected liver test indicates that AST decreased significantly, ALT increased significantly, ALP increased significantly, TP decreased significantly, GLB decreased significantly, TB increased significantly, DB increased significantly, INDB increased significantly. The results of kidney function test show that urea increased significantly, no significant difference shown in creatinine, potassium level were raised significantly, chloride and carbon dioxide were elevated significantly.
Antibacterial Effect of Methanol Extract of Newbouldia laevis Leaves on Some Selected Resistant Pathogen on Synthesised Drugs Umaru, Kerenhappuch Isaac; Ugoeze, Egeonu Stephen; Tansaba, Akafa Andes; Nanmar, Chakfa; Danjuma, Tyem Lawal; Umaru, Isaac John
Kwaghe International Journal of Sciences and Technology Vol 1 No 1 (2024): Kwaghe International Journal of Sciences and Technology
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/kijst.v1i1.3399

Abstract

Newbouldia laevis is a tropical plant belonging to the family of Bignoniaceae. It is among the most useful plants in Africa. Historically medicinal plants have been provided a good source of inspiration for novel therapeutic drugs which has made a large contribution to health and well-being of humans. It has been used over the years to as curative agents against many infections and have been exploited in the traditional medicine with their curative potentials. Material and methods: The leaves of Newbouldia laevis was bought from a local market in Wukari, Taraba State. The leaves of Newbouldia laevis was chop into pieces, air-dried for four days and then pulverized into fine powder. About 250 g of the powdered bark extracted with 2 L of ethanol using maceration method for 72 hrs. The crude extracts of Newbouldia laevis was used in antibacterial assay. The results observed demonstrate that the Newbouldia leaves methanol crude extract possesses concentration-dependent antibacterial activity against both Gram-positive resistant bacteria (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumonia) bacteria. The increasing inhibition zones with higher concentrations suggest a potential dose-response relationship.
Effect of Methanol Leaf Extract of Annona senegalensis on Liver Function in Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats and Its Potential as an Antibacterial Agent Umaru, Isaac John; Udoh, Mary Athanasius; Mona, Etah Hope; Omolara, Mosugu Ovayoza; Okang, Ogar Fonne; Akem, Ingwu Joseph; Tansaba, Akafa Andes; Philip, Shadrach; Frank, Otashu Kenneth
Kwaghe International Journal of Sciences and Technology Vol 2 No 3 (2025): Kwaghe International Journal of Sciences and Technology
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/kijst.v2i3.7362

Abstract

Hepatocellular carcinoma (HCC) is among the most prevalent and deadly cancers globally, with limited treatment options and poor prognosis in advanced stages. This study evaluated the therapeutic potential of methanol leaf extract of Annona senegalensis against diethylnitrosamine (DEN)-induced HCC in Wistar rats and investigated its antibacterial properties. Thirty-six male albino rats were allocated into six groups: Group I (normal control) received no treatment; Group II (negative control) was induced with HCC using DEN (50 mg/kg b.w., intraperitoneally) weekly for three weeks without therapy; Group III (positive control) received DEN followed by silymarin (100 mg/kg b.w.); while Groups IV, V, and VI received DEN followed by A. senegalensis extract at 200, 400, and 600 mg/kg b.w., respectively, administered orally for 14 days. Biochemical analysis showed that the extract significantly (p < 0.05) ameliorated DEN-induced hepatotoxicity, with the 400 mg/kg dose most effective in reducing AST (48.71 ± 1.21 IU/L) and ALT (20.74 ± 1.06 IU/L) compared to the negative control (69.52 ± 0.88 IU/L and 54.97 ± 1.54 IU/L, respectively). Hepatic synthetic function was restored, as indicated by increased total protein (6.37 ± 0.13 g/L) and albumin (5.11 ± 0.10 g/L). Histopathological analysis confirmed marked architectural recovery with reduced necrosis and inflammatory infiltration. The extract also demonstrated significant antibacterial activity, exhibiting dose-dependent inhibition zones against Gram-positive (Staphylococcus aureus, Bacillus subtilis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria, with effects comparable to standard antibiotics. These findings suggest that A. senegalensis leaf extract exerts hepatoprotective effects—likely through antioxidant, anti-inflammatory, and antiproliferative mechanisms—while also offering broad-spectrum antimicrobial benefits. The 400 mg/kg dose emerged as the most effective, highlighting its promise as a cost-effective complementary therapy for managing HCC and bacterial infections, particularly in resource-constrained settings. Further research should focus on isolating and characterizing the bioactive compounds and elucidating their mechanisms of action.
Co-Authors Abbas, Khalid Yahuza Absalom, Augustine Adamu, Usman Lukman Akem, Ingwu Joseph Chisom, Gabriel Favour Danjuma, Tyem Lawal David, Bando Christopher Efongwa, Emmanuel Ekubnse, Nkiri Annasthesia Ekunyi, Agbo Chibuike Frank, Otashu Kenneth Galam, Nanyak Zingfa Ikira, Usman Mona, Etah Hope Nanmar, Chakfa Okang, Ogar Fonne Omolara, Mosugu Ovayoza Onyinyechi, Nwachukwu Favour Philemon, Panah Philip, Shadrach Rebecca, Tsokwa Punarimam Udoh, Mary Athanasius Ugbedeojo, Sule John Ugoeze, Egeonu Stephen Umar, Kerenhappuch Isaac Umaru, Isaac John Umaru, Kerenhappuch Isaac