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All Journal Journal of Multidisciplinary Science: MIKAILALSYS Asian Journal of Science, Technology, Engineering, and Art African Multidisciplinary Journal of Sciences and Artificial Intelligence Open Access DRIVERset African Journal of Biochemistry and Molecular Biology Research Open Access DRIVERset African Journal of Sciences and Traditional Medicine Open Access DRIVERset Kwaghe International Journal of Sciences and Technology Open Access DRIVERset
Ugoeze, Egeonu Stephen
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Evaluation of Potential in Wonderful Kola (Buchiolizia coreica) Seed Extract on Streptozotocin Induced Type 2 Diabetes in Male Wister Rats Umaru, Isaac John; Onyinyechi, Nwachukwu Favour; Tansaba, Akafa Andes; Nanmar, Chakfa; Umaru, Kerenhappuch Isaac; Ugoeze, Egeonu Stephen; Galam, Nanyak Zingfa
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 1 No 1 (2024): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v1i1.3388

Abstract

Diabetes mellitus is referred to as a metabolic disorder in which there is high glucose level in the blood as a result of insulin deficiency, resistance or both. Globally, it has been deducted that the adult population with diabetes will rise by 69% for the year 2030. Thus, Bucholzia Coriacea (B. Coriacea) a perennial plant belonging to the family capparidaceae and genus Bucholzia is popularly known as wonderful kola. It’s also known as wonderful kola, its other name is called Garcinia kola .it has a long history of use in west Africa and central Africa, thus, the study on evaluation of potential in wonderful kola (buchiolizia coreica) seed extract on streptozotocin induced type 2 diabetes in male wister rats. Material and Methods: Fresh seeds of B. coriacea were plucked and washed with distilled water, the filtrate was concentrated using rotary evaporator and water bath. The extract was then weighed and stored in a refrigerator. 100g of crude extract and 1000mg of metformin was properly dissolved in 10ml of distilled water. The rats were carefully selected and separated into cages. 7 albino rats were used for normal control while 4 rats were kept in each of the remaining cages, and 6 replications were obtained, the test was carried out carefully by injecting the alloxan into the rats intraperitoneally and infecting them with diabetes mellitus, the following sets were made: normal group, negative and positive control group, while three groups were for extracts dosage. With exception of the normal control, all the groups were induced with diabetes. The extract (stem bark of Mangifera indica) will be administered orally to the three set of groups separately (i.e., one extract to one set). Determination of Fasting Blood Glucose Level by Intestinal Glucose Absorption. Results: Treatment groups receiving methanol Wonder Kola seed extract showed varying degrees of improvement in these parameters compared to the negative control group. Notably, Group VI, receiving the highest dose of the extract, demonstrated the most significant reduction in urea levels, suggesting a potential protective effect on renal function. The study investigated the effects of Wonder Kola seed extract on serum electrolytes, urea, and creatinine levels in alloxan-induced diabetic albino rats. Notably, significant variations were observed in these biochemical parameters across the different treatment groups. The study assessed the effects of methanol Wonder Kola seed extract on liver enzymes (AST, ALT, ALP) and serum protein levels (total protein, albumin, total bilirubin, direct bilirubin). Significant variations were observed in these parameters among the treatment groups compared to the normal and negative control groups. Treatment with the extract led to notable reductions in liver enzyme levels, indicating potential hepatoprotective effects. Conclusion: The findings of this study demonstrate the potential pharmacological benefits of methanol Wonder Kola seed extract in managing diabetes mellitus and associated complications.
Evaluation of Antibacterial and Anti-Malaria Potential of Wonderful Kola (Buchiolizia coreica) Seed Extract in Male Wister Rats Umar, Kerenhappuch Isaac; Tansaba, Akafa Andes; Ugoeze, Egeonu Stephen; Nanmar, Chakfa; Umaru, Isaac John
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 1 No 1 (2024): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v1i1.3390

Abstract

One of the areas for the search for new antimalarial drugs is from the claimed antimalarial plants from the African flora. Only few of these claims have been authenticated by scientific investigation. Plants form the major part of treatments used by traditional healers in many societies, Bucholzia Coricea (B. Coriacea) a perennial plant belonging to the family capparidaceae and genus Bucholzia is popularly known as wonderful kola. Earlier studies carried out on different parts of this plant shows that it has great medicinal potentials thus, the evaluation of antibacterial and anti-malaria potential of wonderful kola (Bucholzia Coricea) seed extract in male Wister rats. Material and Methods: Fresh seeds of B. coricea were plucked and washed with distilled water, concentrated using rotary evaporator. Standard antibacterial agent (30 μg) tetracycline, antimicrobial susceptibility test discs and Nutrient agar was used. 100g of crude extract taken into a conical flask, the crude extracts were tested by disc diffusion method on nutrient agar medium. selected bacteria were used to evaluate the antibacterial activities of the crude extracts of Bucholizia Coricea seed, Escherichia coli (ATCC©25922), Salmonella typhi, (ATCC©14028), Staphylococcus aureus (ATCC©25923) and Kliebselia pneumonia, (ATCC©19155). A total of seventy-eight Swiss albino mice (18-25 g) of both sexes were used in the study. Eighteen for acute toxicity study while thirty were used for each of the in vivo antiplasmodial test. Results: antibacterial; higher inhibition was observed at 400µg/mL on Klebsiella pneumonia at 15.14 + 0.07mm when compared to standard 21.19+ 0.03mm. while the curative effect of the extract in P. berghei infected rats at 40mg/kg show significant parasitaemia density to be 30.98+4.30 and pre(D3) was 2.90+0.11mm** with survival time at post (D7) to be 29.67+0.21mm when compared to CQ as standard drug control with 10mg/kg. Conclusion: This study has however stablished the rationale for the traditional use of this plant in Nigeria and like many others, proved that medicinal plants which have folkloric reputations for anti-bacterial and antimalarial properties, thus, as an agent.
Co-Authors Adi, Godwin Baaku Akafa, Andes Tensaba Chisom, Gabriel Favour Danjuma, Tyem Lawal David, Bando Christopher Ekubnse, Nkiri Annasthesia Galam, Nanyak Zingfa Nanmar, Chakfa Onyinyechi, Nwachukwu Favour Rebecca, Tsokwa Punarimam Shadrach, Philip Tansaba, Akafa Andes Ugbedeojo, Sule John Umar, Kerenhappuch Isaac Umaru, Isaac John Umaru, Kerenhappuch Isaac