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All Journal Journal of Multidisciplinary Science: MIKAILALSYS Asian Journal of Science, Technology, Engineering, and Art
Nanmar, Chakfa
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Agriculture, Biological Sciences & Forestry Arts Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Engineering Environmental Science Physics Social Sciences Other

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Journal : Journal of Multidisciplinary Science: MIKAILALSYS

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Antidiabetic Potential of Khaya Anthotheca Methanolic Leaves Extract in Streptozotocin Diabetes Induced Rats Umaru, Kerenhappuch Isaac; Tansaba, Akafa Andes; Umaru, Isaac John; Ugoeze, Egeonu Stephen; Nanmar, Chakfa; David, Bando Christopher
Journal of Multidisciplinary Science: MIKAILALSYS Vol 2 No 2 (2024): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v2i2.3191

Abstract

This research evaluated antidibetic potential of methanolic leaves extracts of Khaya anthotheca in streptozotocin induced albino rats. Khaya anthotheca a member of Meliaceae family is traditionally used for treating several ailments. Diabetes is a chronic condition that develops when the pancreas is unable to secrete sufficient amounts of insulin or when the body fails to utilise the insulin that is produced. The leaves were harvested in Sukundi road Wukari and air dried for four weeks, the leaves were pulverized into powder using manual blender and stored in an air tight container. Extraction was done with absolute methanol; the extract was filtered using mesh and the filtrate was concentrated at 68oC. two grams of the filtrate were used for the study; the remainder was used to treat the animals. Using 40 mg/kg body weight of streptozotocin, the animals were divided into 5 groups of 4 each. Following a fourteen-day course of treatment, the animals were sacrificed; the blood was drawn through heart puncture and tested for blood sugar using a glucometer. One-way analysis of variance (ANOVA) was used for statistical analysis. Result of blood sugar level showed significant reduction in all the test groups (p<0.05) except group 2 which showed no significant reduction when compared to the normal control. Conclusion: This study therefore suggests the use of Khaya anthotheca as a diabetic agent and for treatment of diabetes. Further studies are needed to discover the bioactive constituent of the plant responsible for this anti-diabetic activity as well as other pharmacological activities in clinical trials.
GC-MS Profiling and Pathogenic Effect of Khaya Anthotheca Methanolic Leaves Extract on Some Selected Fungi Umaru, Isaac John; Shadrach, Philip; Adi, Godwin Baaku; Ugoeze, Egeonu Stephen; Nanmar, Chakfa; Akafa, Andes Tensaba; Umaru, Kerenhappuch Isaac; David, Bando Christopher
Journal of Multidisciplinary Science: MIKAILALSYS Vol 2 No 2 (2024): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v2i2.3192

Abstract

This research evaluated GC-MS profile, and pathogenic effect of methanolic leaves extracts of Khaya anthotheca on Some Selected fungi. Khaya anthotheca a member of Meliaceae family is traditionally used for treating several ailments. The leaves were harvested in Sukundi road Wukari and air dried for four weeks, the leaves were pulverized into powder using manual blender and stored in an air tight container. Extraction was done with absolute methanol; the extract was filtered using mesh and the filtrate was concentrated at 68oC. Only two grams of the filtrate were used for the GC-MS study. One-way analysis of variance (ANOVA) was used for statistical analysis. The GC-MS result revealed 50 constituents. Result of Methanolic extracts of leaves of Khaya anthotheca only showed significant activity against Aspergillus niger at dose100 µg/mL, Candida tropicalis and Fusarium oxysporium at dose 500 µg/mL. This study supports the use of Khaya anthotheca by indigenous herbalists by providing scientific proof of the plant's ability to treat pothegenic diseases. To establish the effectiveness of this plant in the management of fungal effections, more clinical trials at the clinical levels are needed.
Co-Authors Adi, Godwin Baaku Akafa, Andes Tensaba David, Bando Christopher Shadrach, Philip Tansaba, Akafa Andes Ugoeze, Egeonu Stephen Umaru, Isaac John Umaru, Kerenhappuch Isaac