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All Journal The Journal of Society Medicine (JSOCMED) Neurona
Pujiastuti, R. A. Dwi
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Osmolarity Changes after Mannitol Administration in Cerebral Edema Patients Tampubolon, Monica; Iqbal, Kiki M.; Pujiastuti, R. A. Dwi
Journal of Society Medicine Vol. 2 No. 7 (2023): July
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i7.71

Abstract

Introduction: Cerebral edema is commonly associated with cerebral pathology, and the clinical manifestation is greatly influenced by the underlying damaged tissue. Mannitol is the most widely used osmotic agent to reduce intracranial pressure. Giving osmotic therapy with 20% mannitol has the benefit of reducing ICP but can increase plasma osmolarity which can increase the risk of kidney disorders in patients with cerebral edema. This study aimed to assess osmolarity changes after mannitol administration in cerebral edema patients. Method: This is a pre-experimental study with a one-group pretest-posttest design. The research subjects were taken from the patient population of H. Adam Malik General Hospital Medan and Network Hospitals. The determination of research subjects was carried out according to the non-random sampling method consecutively and obtained as many as 32 research samples conducted from December 2022-April 2023. To determine changes in plasma osmolarity, a paired t-test was performed. Results: The mean osmolarity before mannitol administration was 303.74±11.59 mOsm/L and after mannitol administration was 307.01±14.83 mOsm/L, with an average change in osmolarity was 3.27±12.19 mOsm/L. There were no significant changes in mean plasma osmolarity after administration of mannitol (p=0.139). Based on the analysis of laboratory components, a significant increase in BUN values was found after the administration of mannitol (p=0.003). Conclusion: In patients with cerebral edema, mannitol treatment is generally safe and does not result in clinically significant electrolyte abnormalities. But during and after mannitol therapy, electrolyte and renal function monitoring is required.
HUBUNGAN KADAR TRANSFORMING GROWTH FACTOR BETA DENGAN DERAJAT NYERI PADA MIGRAIN DAN TENSION-TYPE HEADACHE Ningsih, Nadya Ayu; Surbakti, Khairul Putra; Pujiastuti, R. A. Dwi
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 42 No 1 (2025): Volume 42, No 1 - Desember 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v42i1.815

Abstract

ABSTRACT Introduction: Primary headaches, which mainly include Tension-type Headache (TTH) and migraine, account for 90% of all headaches and are the leading cause of disability worldwide. Migraine and TTH have pathogenesis that is not fully known, with one theory proposing neurogenic inflammation. Human Transforming Growth Factor β (TGF-β) is a pro-inflammatory cytokine that is thought to be involved in the occurrence of migraine and TTH. Objective: To determine the correlation between human TGF-β levels and the pain severity in migraine and TTH. Methods: This study used a cross-sectional design in patients with a diagnosis of migraine and TTH who sought treatment at the Ambulatory Clinic of Adam Malik Hospital and Prof. Dr. Chairuddin P. Lubis Hospital. We use Numeric Rating Scale score to determine the pain severity and ELISA kit to measure the TGF-β levels. This study involved 30 patients who met the inclusion and exclusion criteria. Results: The study subjects were found to be mostly female, 22 people (73.3%), with the age range of 18 to less than 26 years which was 20 people (66.7%). The mean TGF-β level of patients was 0.400±0.531 ng/mL. The mean pain severity of patients was 2.60±2.415. The results of the Spearman correlation test showed a moderate positive correlation (r: 0.523) which was found significant with a p value of 0.003 between TGF-β and the pain severity in migraine and TTH. Conclusion: There was significant correlation between human TGF-β levels and pain severity in migraine and TTH. Keywords: migraine, pain severity, TGF-β, TTH
Co-Authors Iqbal, Kiki M. Ningsih, Nadya Ayu Surbakti, Khairul Putra Tampubolon, Monica