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Estimated Glomerular Filtration Rate (eGFR) as a Predictor of 1-Month Clinical Outcome in First-Ever Acute Ischemic Stroke Patients Billi; Akbar, Muhammad; David Gunawan Umbas; Hamid, Firdaus; Bintang, Andi Kurnia; Lotisna, Mimi
Journal of Society Medicine Vol. 2 No. 12 (2023): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i12.110

Abstract

Introduction: Renal dysfunction is a new risk factor that is thought to influence the clinical outcome of acute ischemic stroke. In this case, the estimated glomerular filtration rate (eGFR) value is used as an approach to assess kidney function status in acute ischemic stroke patients. This study aims to find the relationship between eGFR and clinical outcomes of acute ischemic stroke. Method: 70 samples were obtained according to inclusion criteria. eGFR is calculated within first week of stroke onset using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. A normality test was carried out on the data, then determined the correlation and compared eGFR with good [modified Rankin Scale (mRS) 0-2] and poor (mRS 3-6) clinical outcomes on the 30th day. Results: In this study, the average age of the sample was 61.37 years. The largest population was in the 45-59 mL/min/1.73 m2 eGFR group (38,6%). The mean eGFR (p<0.001) for all samples, good, and bad outcome groups was respectively 59.90 ± 21.09, 79.79 ± 19.21, and 52.49 ± 16.57. In this study the poor outcome group had a lower mean eGFR than the good outcome group (52.49 mL/min/1.73 m2 vs 79.79 mL/min/1.73 m2), with a cut-off value of 62 mL/min/1.73 m2 (sensitivity 80.39%, specificity 84.21%) tended to have worse clinical outcomes. Conclusion: Based on the results of this study, eGFR has a relationship with clinical outcomes (p<0.001) and can objectively predict clinical outcomes on the 30th day of acute ischemic stroke.
Rabies: Diagnostic, Treatment, and Prevention Bintang, Andi Kurnia; Basri, Muhammad Iqbal; Lotisna, Mimi; Carrey, Michael
Nusantara Medical Science Journal Volume 8 Issue 2, July - December 2023
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.27671

Abstract

Rabies is a neurological disease with fatal impacts because it has a high mortality rate. Animals, primarily dogs, mediate the spread of rabies. Clinical findings of rabies are divided into two categories: classic rabies (furious type) and paralytic type. Furious rabies has many cardinal features, such as fluctuating consciousness, aerophobia or hydrophobia, inspiratory spasm, and autonomic dysfunction. Ascending paralysis with a lower motor neuron lesion is the initial sign of paralytic rabies. The rabies virus invades and lives in neurons. It is virulent. Besides clinical findings, the diagnostic approach can involve radiology, microbiology, and histopathology. There are not only symptomatic treatments for rabies patients but also vaccines, immunoglobulin, and antivirals to decrease the progressivity of the disease. Vaccination programs and animal control have become essential in reducing rabies cases in Indonesia.