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Efek Pemberian Vitamin D Terhadap Penderita Rinitis Alergi Hasbullah, Ayu Ameliyah; Rahardjo, Sutji P; Punagi, Abdul Qadar; Savitri, Eka; Hamid, Firdaus
Jurnal Ilmiah Ecosystem Vol. 22 No. 1 (2022): ECOSYSTEM Vol. 22 No 1, Januari - April Tahun 2022
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35965/eco.v22i1.1521

Penelitian ini bertujuan untuk mengetahui efek pemberian vitamin D terhadap perubahan kadar kalsiferol serum dan perubahan gejala klinis terhadap penderita rinitis alergi. Penelitian ini menggunakan uji klinis (clinical trials) terhadap 40 orang penderita rinitis alergi, dimana 20 pasien menggunakan kortikosteroid intranasal sebagai terapi dengan tambahan vitamin D, dan 20 pasien sebagai kontrol. Pengukuran kadar kalsiferol serum, pengukuran derajat rinitis alergi menurut ARIA, dan pengukuran total nasal symptom score (TNSS) dilakukan sebanyak 2 kali yaitu sebelum perlakuan dan setelah perlakuan. Data kemudian di analisis menggunakan uji-t berpasangan, uji chi-square, dan uji Wilcoxon ranks. Hasil penelitian didapatkan perbedaan bermakna kadar kalsiferol serum antara sebelum perlakuan dan setelah pemberian terapi tambahan vitamin D. Terdapat juga penurunan skor TNSS dan derajat rinitis alergi secara bermakna (p < 0,001) pada kelompok yang diberikan perlakuan berupa terapi tambahan vitamin D. Kemaknaan klinik adalah pemberian terapi tambahan vitamin D akan memperbaiki kadar kalsiferol serum, skor TNSS, dan derajat rinitis alergi jika dibandingkan dengan pemberian terapi standart saja.

Estimated Glomerular Filtration Rate (eGFR) as a Predictor of 1-Month Clinical Outcome in First-Ever Acute Ischemic Stroke Patients Billi; Akbar, Muhammad; David Gunawan Umbas; Hamid, Firdaus; Bintang, Andi Kurnia; Lotisna, Mimi
Journal of Society Medicine Vol. 2 No. 12 (2023): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i12.110

Introduction: Renal dysfunction is a new risk factor that is thought to influence the clinical outcome of acute ischemic stroke. In this case, the estimated glomerular filtration rate (eGFR) value is used as an approach to assess kidney function status in acute ischemic stroke patients. This study aims to find the relationship between eGFR and clinical outcomes of acute ischemic stroke. Method: 70 samples were obtained according to inclusion criteria. eGFR is calculated within first week of stroke onset using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. A normality test was carried out on the data, then determined the correlation and compared eGFR with good [modified Rankin Scale (mRS) 0-2] and poor (mRS 3-6) clinical outcomes on the 30th day. Results: In this study, the average age of the sample was 61.37 years. The largest population was in the 45-59 mL/min/1.73 m2 eGFR group (38,6%). The mean eGFR (p<0.001) for all samples, good, and bad outcome groups was respectively 59.90 ± 21.09, 79.79 ± 19.21, and 52.49 ± 16.57. In this study the poor outcome group had a lower mean eGFR than the good outcome group (52.49 mL/min/1.73 m2 vs 79.79 mL/min/1.73 m2), with a cut-off value of 62 mL/min/1.73 m2 (sensitivity 80.39%, specificity 84.21%) tended to have worse clinical outcomes. Conclusion: Based on the results of this study, eGFR has a relationship with clinical outcomes (p<0.001) and can objectively predict clinical outcomes on the 30th day of acute ischemic stroke.

High Density Lipoprotein (HDL) Level and Blood Urea Nitrogen (BUN)/Creatinin Ratio Relationship with One-Month Outcome in Acute Ischemic Stroke Patients Habib Djarkoni, Ilham; Iqbal Basri, Muhammad; Akbar, Muhammad; Hamid, Firdaus; Kurnia Bintang, Andi; Tamasse, Jumraini
Journal of Society Medicine Vol. 2 No. 12 (2023): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i12.112

Introduction: Stroke has caused around 15.5% of all deaths. Evaluation of factors that worsen clinical outcomes is necessary to avoid complications such as renal dysfunction and secondary dyslipidaemia. This study aims to determine the relationship between increasing serum HDL levels and blood urea nitrogen–serum creatinine ratio (BUN/Cr) on clinical outcomes of acute ischemic stroke. Method: Prospective cohort study was used with subjects being first-onset acute ischemic stroke patients. Demographic, clinical data, and assessment of BUN/Cr and HDL ratios were collected. Subjects were divided into good clinical outcome (mRS 0-2) and poor clinical outcome (mRS 3-6) groups, and then analysed using multiple linear regression multivariate analysis with confidence interval of 95%. Results: 60 participants met the inclusion criteria. There was a significant relationship between serum BCR levels and poor clinical outcomes (p <0.001) relationship between serum HDL levels and poor clinical outcomes also shown significances (p <0.001) Mean BCR in good and poor clinical outcomes of acute ischemic stroke were (17.08±30.13) and (29.35±67.30) respectively. Mean HDL in good and poor clinical outcomes were (39± 62) and (41 ± 92) respectively. A multiple linear regression analysis showed a positive correlation (p <0.001) between increasing Serum HDL levels and Bun/Cr ratio simultaneously to poor clinical outcomes in acute ischemic stroke patients. The Cut-off point was 20.9 for BUN to creatinine ratio and 46 mg/dL at serum HDL. Both of BUN/Cr ratio and HDL were shown high specificity and could be used as predictors of clinical outcome in acute ischemic stroke patients. Conclusion: Increased BUN/Cr ratio and increased serum HDL levels were associated with clinical outcomes in patients with acute ischemic stroke.

Fluor Albus Characteristics Associated with Sexually Transmitted Infection (STI) in Makassar Pregnant Women Haruna, Nadyah; Hatta, Mochammad; Hamid, Firdaus; Madjid, Baedah; Patellongi, Ilhamjaya; Farid, Monika Fitria
Al-Sihah : The Public Health Science Journal Volume 15, Nomor 2, July-December 2023
Publisher : Program Studi Kesehatan Masyarakat UIN Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-sihah.v15i2.38797

Sexually Transmitted Infection (STI) is a common condition with increased prevalence among pregnant women and can negatively affect the fetus. According to WHO, a total of 374 million new cases of STI are projected to occur in 2020, including gonorrhea (82 million), syphilis (7.1 million), and trichomoniasis (156 million). Therefore, this study aimed to determine the relationship between the characteristics of vaginal discharge (fluor albus) in pregnant women and STI. The descriptive method was used with a cross-sectional design, and the procedures were conducted in May 2023. The sample population comprised all pregnant women with ANC in Makassar during the study period. Vaginal swabs were obtained from 127 pregnant women who were willing to participate and had vaginal discharge. The results showed that 53 participants reported having physiological flour albus, while 74 had pathological symptoms. Itching and odor were reported to be the most common clinical signs associated with patients' abnormal vaginal discharge, followed by itching, pain, and odor. Furthermore, a significantly high prevalence of the condition was observed among pregnant women aged 20-30 years. Based on the results, the predominant symptom of fluor albus was itching and odor when combined with microorganisms that caused STI. Several pregnant women with clinical complaints also had microorganisms apart from those associated with STI. These results indicated the pressing need to develop additional testing in pregnant women with fluor albus, particularly those with concomitant symptoms.

Hubungan antara Kadar Hepsidin dan Kadar Hemoglobin pada Kehamilan dengan Obesitas Ratnaningsih, Andi Sri; Sunarno, Isharyah; Madya, Fatmawati; Hamid, Firdaus; Irianta, Trika; Susiawaty, Susiawaty
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.583

Tujuan: Untuk menilai kadar Hepsidin dan kadar hemoglobin menggunakan sampel darah dan selanjutnya dianalisis dengan metode ELISA.Metode: Penelitian ini merupakan kohort prospektif pada perempuan hamil dengan obesitas dan pembanding non-obesitas pada trimester pertama dan kedua di RSUP Dr. Wahidin Sudirohusodo dan Rumah Sakit Pendidikan Jejaring pada periode Januari - Agustus 2022.Hasil: Penelitian dilakukan terhadap 44 sampel yang terdiri atas 22 sampel kelompok ibu hamil dengan obesitas dan 22 sampel ibu hamil dengan IMT normal. Pada pasien obesitas tidak didapatkan korelasi antara kadar Hepsidin dan kadar hemoglobin di trimester pertama dengan nilai p=0.097 sedangkan pada trimester kedua terdapat korelasi dengan nilai p=0.028. Pada pasien non obesitas tidak didapatkan korelasi antara kadar Hepsidin dengan kadar hemoglobin nilai p=0.489 di trimester pertama dan nilai p=0.906 di trimester kedua.Kesimpulan: Peningkatan kadar Hepsidin dan anemia dapat ditemukan pada wanita obese yang sedang hamil, terutama pada trimester kedua.The Relationship Between Hepcidin Levels And Hemoglobin Levels In Pregnancy With ObesityAbstract Objective: To compare hepcidin levels and hemoglobin levels using blood samples and further analyzed with ELISA method.Method: This study is a prospective cohort of obese pregnant women and a non-obese comparator in the first and second trimesters at RSUP Dr. Wahidin Sudirohusodo Hospital and Networking Teaching Hospitals in the period January - August 2022.Results: The study was conducted on 44 samples consisting of 22 samples of obese pregnant women and 22 samples of pregnant women with normal BMI. In obese sample, there was no correlation between hepcidin levels and hemoglobin levels in the first trimester with a value of p=0.097 while in the second trimester there was a correlation with a value of p=0.028. In non-obese patients, there was no correlation between hepcidin levels and hemoglobin levels, p = 0.489 in the first trimester and p= 0.906 in the second trimester.Conclusion: Increased hepcidin levels and anemia can be found in obese women in the second trimester of pregnancy.Key words: Hepcidin, Obesity, Hemoglobin

Computational drug repurposing for tuberculosis by inhibiting Ag85 complex proteins Iskandar, Israini W.; Nurhasanah, Astutiati; Hatta, Mohammad; Hamid, Firdaus; Handayani, Irda; Chaera, Ummi; Yusriyyah, Andi A.; Jamaluddin, Balqis D.; Zaenab, St; Hidayah, Najdah; Karimah, Nihayatul; Permana, Andi D.; Massi, Muhammad N.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1130

Tuberculosis (TB) remains a significant and deadly infection among pulmonary diseases caused by Mycobacterium tuberculosis, a highly adaptive bacterium. The ability of M. tuberculosis to evade certain drugs has been linked to its unique structure, particularly in the cell envelope, where the Ag85 complex proteins play an essential role in this part. The aim of this study was to utilize a drug repurposing strategy targeting the Ag85 complex proteins. This study utilized a computational approach with 120 selected drugs experimentally identified to inhibit Tuberculosis. A virtual screening molecular docking with Autodock Vina was used to filter the compounds and identify the strong binders to the Ag85 Complex. Molecular dynamics simulations employed the Gromacs Packages to evaluate the stability of each complex, including root mean square deviation (RMSD), root mean square fluctuation (RMSF), and radius of gyration (RoG). Additionally, absorption, distribution, metabolism, excretion, and toxicity (ADMET) assessments were conducted to gather more information about the drug-likeness of each hit compound. Three compounds, selamectin, imatinib, and eltrombopag were selected as potential drugs repurposed to inhibit the activity of the Ag85 complex enzyme, with binding affinities ranging between -10.560 kcal/mol and -11.422 kcal/mol. The MD simulation within 100 ns (3 replicas) showed that the average RMSD of each Ag85A complex was 0.15 nm–0.16 nm, RMSF was 0.09 nm–0.10 nm, and RoG was 1.80 nm–1.81 nm. For Ag85B, the average RMSD was 1.79 nm–1.80 nm, RMSF was 0.08 nm–0.09 nm, and RoG was 1.79 nm – 1.80 nm. Then, for Ag85C, the mean RMSD was 0.16 nm–0.18 nm, RMSF was 0.09, and RoG was 1.77 nm. The study highlights that these promising results demonstrate the potential of some repurposed drugs in combating the Ag85 complex.

Accuracy of Transperineal Ultrasoun Examination in Predicting Vaginal Delivery Rauf, Fauzia Tamara; Chalid, Maisuri Tadjuddin; Lukas, Efendi; Susiawaty; Farid, Monika Fitria; Hamid, Firdaus
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 1 January 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i1.2184

Prevalence human papillomavirus type 6 and type 11 in pregnant women Haruna, Nadyah; Hatta, Mochammad; Hamid, Firdaus; Sultan, Andi Rofian; Safri, Safri; Farid, Monika Fitria; Lestari, Esa
MEDISAINS Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.23103

Background: Pregnancy reduces the effectiveness of cell-mediated immunity, making the body more vulnerable to Human Papilloma Virus (HPV) infection. HPV comes in multiple variants, including non-pro-oncogenic varieties like 6 and 11. Less research has been done on low-risk HPV infections than on high-risk HPV since they are more frequently linked to genital warts and rarely result in cancer. Examples of these infections are types 6 and 11. It is necessary to conduct this study to ascertain whether asymptomatic pregnant women have been exposed to HPV types 6 and 11.Purpose: This study aims to determine prevalence HPV types 6 and 11 in pregnant women.Methods: A descriptive cross-sectional survey was carried out in Makassar in May 2023. The study Population consisted of pregnant women who underwent antenatal care at Tajuddin Chalid Hospital Makassar during the specified research period. After providing clarification and obtaining consent from eligible mothers, we collected a swab from the vaginal area. A PCR examination was conducted on the 167 maternal swabs that were received. Statistical analyses included frequency distribution using SPSS.Results: According to the study, 121 (72.5%) of the 167 samples tested positive for HPV type 6 DNA, while 46 (27.5%) tested negative. Meanwhile, 67% of 167 patients tested positive for HPV type 11 but were negative for the virus. Only 21 respondents with negative identification were found to be harboring both low-risk Human Papillomavirus types. In addition, 78 respondents received positive results for HPV types 6 and 11.Conclusion: Pregnant women can be infected with HPV types 6 and 11 even if they are asymptomatic. The high percentage of positive results suggests that routine maternal screening is recommended, especially during pregnancy.

VALIDITAS MICHIGAN NEUROPATHY SCREENING INSTRUMENT VERSI BAHASA INDONESIA DALAM MENDETEKSI POLINEUROPATI DISTAL SIMETRIS DIABETIKA Bintang, Andi Kurnia; Aulina, Susi; Goysal, Yudy; Amran, Muhammad Yunus; Hamid, Firdaus; Setiawan, Denise Dewanto
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 3 (2024): Volume 40, No 3 - Juni 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i3.436

Introduction: Distal Symmetric Polyneuropathy (DSPN) is the most common neuropathy subtype found in Diabetes Mellitus (DM) patients. Early screening is important to prevent complications. Michigan Neuropathy Screening Instrument (MNSI) was created in 1994 as an alternative screening tool for diabetic neuropathy. This instrument has not been validated in Indonesia. Aim: Assess validity and reliability of Indonesian version of MNSI in detecting diabetic DSPN. Methods: This cross-sectional study was done in Wahidin Sudirohusodo hospital, Makassar in December 2021-June 2022. Indonesian version of MNSI and Nerve Conduction Studies (NCS) was applied to subjects. Statistics were performed with Statistical Package for the Social Sciences (SPSS) version 25. Study protocol was approved by Health Research Ethics Committee, Faculty of Medicine, Hasanuddin University. Results: 102 subjects were eligible and divided into DM with DSPN (n=60) and DM without DSPN (n=42). Significant differences were found in age, body mass index, duration of DM diagnosis, treatment, HbA1c, Indonesian version of MNSI part B, and all NCS parameters (p<0,05). Area Under Curve (AUC) of part B was bigger than A (0,942 vs 0,606). Cut-off >=2,5 of part B had sensitivity, specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV) of 95,0%, 90,5%, 93,4%, and 92,7%, respectively. Discussion: Cut-off >=2,5 for Indonesian version of MNSI part B was considered optimal. EMNG was recommended for DM patients with part B score >=2,5. Conclusion: Indonesian version of MNSI is a valid and reliable instrument to detect DSPN in Indonesian population. Keywords: diabetic neuropathy, DSPN, Indonesia, MNSI

Prevalence human papillomavirus type 6 and type 11 in pregnant women Haruna, Nadyah; Hatta, Mochammad; Hamid, Firdaus; Sultan, Andi Rofian; Safri, Safri; Farid, Monika Fitria; Lestari, Esa
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.23103

Background: Pregnancy reduces the effectiveness of cell-mediated immunity, making the body more vulnerable to Human Papilloma Virus (HPV) infection. HPV comes in multiple variants, including non-pro-oncogenic varieties like 6 and 11. Less research has been done on low-risk HPV infections than on high-risk HPV since they are more frequently linked to genital warts and rarely result in cancer. Examples of these infections are types 6 and 11. It is necessary to conduct this study to ascertain whether asymptomatic pregnant women have been exposed to HPV types 6 and 11.Purpose: This study aims to determine prevalence HPV types 6 and 11 in pregnant women.Methods: A descriptive cross-sectional survey was carried out in Makassar in May 2023. The study Population consisted of pregnant women who underwent antenatal care at Tajuddin Chalid Hospital Makassar during the specified research period. After providing clarification and obtaining consent from eligible mothers, we collected a swab from the vaginal area. A PCR examination was conducted on the 167 maternal swabs that were received. Statistical analyses included frequency distribution using SPSS.Results: According to the study, 121 (72.5%) of the 167 samples tested positive for HPV type 6 DNA, while 46 (27.5%) tested negative. Meanwhile, 67% of 167 patients tested positive for HPV type 11 but were negative for the virus. Only 21 respondents with negative identification were found to be harboring both low-risk Human Papillomavirus types. In addition, 78 respondents received positive results for HPV types 6 and 11.Conclusion: Pregnant women can be infected with HPV types 6 and 11 even if they are asymptomatic. The high percentage of positive results suggests that routine maternal screening is recommended, especially during pregnancy.

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