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All Journal Indonesian Journal of Global Health research The Journal of Society Medicine (JSOCMED)
Syahputri, Fitriend
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Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Relationship between Plasma Fibronectin Levels and Stretch Marks Syahputri, Fitriend; Imam Budi Putra; Nelva K. Jusuf
Journal of Society Medicine Vol. 3 No. 4 (2024): April
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i4.132

Abstract

Introduction: Stretch marks or striae distensae are linear atrophic scars that form in areas of skin damage as a result of skin stretching. Mast cell degranulation and activation of macrophages occur as well as changes in the components of the extracellular matrix, including fibronectin. Fibronectin as a dimeric glycoprotein and components contained in the extracellular matrix, functions as a regulator of cellular processes, to maintain tissue and functions in the process of wound healing in tissues. The aim of this study was to determine the relationship between plasma fibronectin levels and stretch marks Methods: This study was an observational study with a cross-sectional design of 40 females with stretch marks and 40 controls. Each patient underwent history, dermatological examination, and blood sampling to assess plasma fibronectin levels by ELISA test. These data were analyzed statistically using the Chi square test. Results: The mean plasma fibronectin level in stretch marks was 259.541±165.937 ng/ml. The highest age with stretch marks was 18–25 years 33 (82.5%) people. Most of them had a family history of stretch marks from their mother 20 (50%) people. The majority of stretch marks are located on gluteus regions by 10 people (25%). The result of this study showed that there was a relationship between plasma fibronectin levels causing a risk of 2.85 times for stretch marks (p = 0.041). Conclusion: There is a relationship between plasma fibronectin levels and stretch marks.
Cutaneous Polyarteritis Nodosa: A Case Report Syahputri, Fitriend; Dalimunthe, Dina Arwina; Hutapea, Richard
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6618

Abstract

Cutaneous polyarteritis nodosa is a rare type of vasculitis that involves inflammation in small to medium-sized blood vessels, mainly targeting the skin. It affects people of all ages and significantly impacts both the skin and other organ systems. This case report aims to describe the clinical presentation, diagnostic approach, and therapeutic response. A 38-year-old man came with a two-week history of a red, non-itchy rash on both legs. A week before the rash appeared, patient experienced fever, sore throat, and stomach pain. His general condition was stable. Dermatological examination showed multiple palpable purpura on both legs, ranging from miliary to lenticular in size. Diascopy revealed non-blanching purpura, and dermoscopy showed a homogeneous pattern of multiple erythematous spots. Histopathology indicated a proliferation of blood vessels with enlarged endothelial cells, concluding with a diagnosis of polyarteritis nodosa. Patient was diagnosed with cutaneous polyarteritis nodosa and treated with methylprednisolone at 1 mg/kg/day, divided into three doses of 32 mg each, with tapering off every week. Clinical improvement was observed, and the skin lesions progressively resolved. This case highlights the importance of early recognition and corticosteroid therapy in the successful management of mild cutaneous polyarteritis nodosa. Keywords: corticosteroid, cutaneous polyarteritis nodosa, vasculitis
Co-Authors Dina Arwina Dalimunthe, Dina Arwina Hutapea, Richard Nelva K. Jusuf Putra, Imam Budi