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The Relationship of Blood Eosinophils Levels with Degree of Exacerbation in COPD Patient at Usu General Hospital Deneuve, Olivia Monica; Pradana, Andika; Tarigan, Amira P.
Journal of Society Medicine Vol. 3 No. 7 (2024): July
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i7.155

Abstract

Introduction: During acute exacerbations of chronic obstructive pulmonary disease (COPD), blood eosinophil count has the potential to predict treatment response. Nevertheless, there hasn't been enough research done to determine whether blood eosinophil numbers in a stable state can forecast an eosinophilic exacerbation. Methods: This study was a retrospective cohort analysis performed July-August 2022 to July-August 2023. Subject were 44 COPD patients who were treated at the outpatient clinic. Blood samples measured blood eosinophil levels. We determined an absolute cut-off point for blood eosinophil count at stable COPD in order to identify the rate of exacerbation. Results: Based on the Kruskal-Walli’s test, there was a significant relationship between blood eosinophils and the level of exacerbations in COPD patients (p value = 0.003). Conclusion: We established a relationship between the rate of exacerbation and blood eosinophil counts during stable COPD. The rate of exacerbation and eosinophil counts showed a strong positive relationship. Our findings should be confirmed by prospective and further research in different populations.
The Relationship Between ICS LABA Administration and Blood Eosinophil Levels in COPD Patient at USU General Hospital Deneuve, Olivia Monica; Pradana, Andika; Tarigan, Amira P
Journal of Society Medicine Vol. 3 No. 12 (2024): December
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i12.180

Abstract

Introduction: Blood eosinophil count may predict treatment response in patients  with chronic obstructive pulmonary disease (COPD) during acute exacerbations. However,  the ability of blood eosinophil counts in stable status to predict eosinophilic. Method: This was a cohort retrospective study performed Juni-August 2022 to Juni-August 2023. Subject were COPD patients who were treated at the outpatient using ICS LABA therapy. Blood samples measured blood eosinophil levels first and control. Results: Based on Wilcoxon test test, there was a significant positive positive correlation of eosinophil counts between ICS LABA  Administration and Blood Eosinophil Levels in COPD Patient at USU General Hospital. Conclusion: We demonstrated association between ICS LABA Administration and Blood  Eosinophil Levels in COPD Patient (p value = 0.02).