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All Journal Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional
Obike, Chiemeziem Adanma
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Physicochemical, Antimicrobial, Lethality and In Vitro Antioxidant Profiles of Johnu Tisane: A Coffee (Coffea Arabica) Leaf Decoction Formula Egbuonu, Anthony Cemaluk Chinedum; Alaebo, Prince Ogochukwu; Onuoha, Udumma Nsofor; Njoku, Chinomso Juliet; Obike, Chiemeziem Adanma; Nlemadim, Susan Ogechi; Chukwu, Blessing Ifeoma; Iwejuo, Sopuruchi Mary-Augusta; Amaechi, Onyedikachi Glory; Obiefuna, Victor Ifechukwu; Onuoha, Bessing Nmesomachi; Okoli, DivineTreasure Nzubechukwu; Nwokeoma, Precious Chinonso; Eze, Chukwubuikem
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.99-107

Abstract

Coffee leaves-based tea has relevance in ethno-medications due to its rich phyto-constituents-related diverse pharmacologic activities. Jonhu tisane, a typical Coffea arabica leaf decoction has no supporting scientific basis amidst reported location, processing and specie-related variations. This investigated physicochemical, antimicrobial, lethality and in-vitro antioxidant profiles of Johnu tisane by acceptable methods. Results recorded moisture (92.26 %), ash (0.65 %), unsaponified matter (1.46 mg/100 g), free fatty acid (0.56 mgKOH/g), acid value (1.12 mgKOH/g), potential hydrogen (6.85), lethal concentration (1000 ppm) and concentration-dependent antimicrobial activity. Anti-oxidation results revealed total antioxidant capacity, ferric reducing antioxidant power, nitric oxide, hydrogen peroxide and 2, 2-diphynyl-1-picrylhydrazyl scavenging activities increased concentration-dependently compared to standard. Thus, Johnu tisane demonstrated low minerals and keeping quality; requisite physicochemical mix for consumption and bioactivity; high safety margin; antimicrobial potency; and requisite anti-oxidation capacity for in-vivo antioxidant role. These provided scientific support for its ethno-medicinal uses. They underscored the need to elucidate its pharmacologically active compounds; mechanistic roles in animal models; and the impact of ash to moisture mix variation on potential hydrogen, microbial and antimicrobial activities in relation to shelf life, bioactivity and in vivo anti-oxidative roles for novel insights on preserving sample quality, safety, bioactivity and in-vivo anti-oxidative outcomes.
Anti-hyperlipidemic and Biochemical Effect of Aqueous Extract of Combretum dolichopetalum in High Cholesterol Diet Fed Rats Emelike, Chinedum Uche; Obike, Chiemeziem Adanma; Ekakitie, Ofovwe Obruche; Ahuekwe, Eze Frank
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95014

Abstract

It is commonly known that atherosclerosis and coronary heart disease (CAD) are associated with hyperlipidemia, which is brought on by abnormalities in the transportation, production, or catabolism of cholesterol. Hence, preventing hyperlipidemia can positively impact managing and treating cardiovascular diseases. This present study aimed to examine the possible aqueous extract's effects of Combretum dolichopetalum (AECD) on liver indices and lipid status in rats on a diet rich in cholesterol. Five groups of twenty-five male albino Wistar rats, weighing between 130 and 160 grams, were assembled. Group A (Standard control group), Group B (Hyperlipidemic control), Group C (treatment): which received high cholesterol diet (HCD) + AECD (200 mg/kg bwt.), Group D: HCD + AECD (400 mg/kg bwt), Group E: HCD + atorvastatin (standard drug) (30 mg/kg bwt). The rats were sacrificed on day 28th of the experiment, and samples were obtained for liver indices and lipid profile using standard protocols. The findings show that the treatment groups' lipid profile was significantly lower (p < 0.05) than those of the hyperlipidemic controls. The liver enzymes; alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), and total bilirubin (TB), direct bilirubin (DB), remain unchanged across all groups. These findings suggest that AECD is beneficial in lowering cholesterol levels and does not have a toxic effect on the liver.
Co-Authors Ahuekwe, Eze Frank Alaebo, Prince Ogochukwu Amaechi, Onyedikachi Glory Chukwu, Blessing Ifeoma Egbuonu, Anthony Cemaluk Chinedum Ekakitie, Ofovwe Obruche Emelike, Chinedum Uche Eze, Chukwubuikem Iwejuo, Sopuruchi Mary-Augusta Njoku, Chinomso Juliet Nlemadim, Susan Ogechi Nwokeoma, Precious Chinonso Obiefuna, Victor Ifechukwu Okoli, DivineTreasure Nzubechukwu Onuoha, Bessing Nmesomachi Onuoha, Udumma Nsofor