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All Journal Biology, Medicine, & Natural Product Chemistry Asian Journal of Science, Technology, Engineering, and Art
Abubakar, Auwal
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Arts Biochemistry, Genetics & Molecular Biology Computer Science & IT Engineering Medicine & Pharmacology Public Health Social Sciences

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Isolation and Characterisation of Essential oils of Mango (M. indica) Leave Abubakar, Auwal; Shagal, Mohammed Hassan; Milan, Charles
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.1-6

Abstract

This research work aimed at isolation and characterisation of essential oils of Mangifera. indica (M. indica) leaves. Phytochemical screening was carried out to determine the bioactive components present in the leaf sample as well as the antimicrobial activity of the crude ethanolic extract. The percentage yield of essential oils (colourless) of the leaf was 0.19%. The phytochemical screening revealed the presence of alkaloid, glycoside, flavonoid, saponin and tannin.  Steroids was absent in the extract. The antimicrobial evaluation of the essential oil of M. indica leaf revealed a significant activity (zone of inhibition). The percentage (%) of Diphenyl picryl hydrazine (DPPH) scavenged of antioxidant activities for the essential oils of M. indica at different concentration of 5µl, 10µl, 25µl and 100 µl showed a significant antioxidant activity. In concluded results, it’s clearly observed that, when the concentration of both ethanolic extract and essential oils leaf sample increases, the antimicrobial and antioxidant properties increases when compared to the standard (Amoxicillin) and that of essential oils has a significant property than other extracts. Considering the results of phytochemical screening, it’s also a potential source of cost-effective food supplements, nutritive ingredients and antibacterial agent for improving human health and curing acute and chronic diseases. The GC-MS analysis of the essential oils for the leaf sample revealed fifty two (52) different chemical compounds which include Alloaromadendrene, Humulene, Bicyclo[4,4,0]dec-1-ene, 2-isopropyl-5-methyl-9-methylene, Bicyclo[7.2.0]undec-4-ene,4,11,11,-trimethyl 8-methylene-,[1R-(1R*,4Z,9S*)].
Genotypic Detection of Dominant Bacteria in Dental Caries in Uyo, Nigeria Udoh, Mary Athanasius; Onwuezobe, Ifeanyi Abraham; Abdulkadir, Rasheedat; Abubakar, Auwal; Yahaya, Musbau Adekunle; Onah, Daniel Oche
Asian Journal of Science, Technology, Engineering, and Art Vol 3 No 3 (2025): Asian Journal of Science, Technology, Engineering, and Art
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstea.v3i3.5799

Abstract

Dental caries remains one of the most prevalent and persistent oral health challenges globally, with nearly universal incidence across populations. The disease is increasingly complicated by the emergence of antibiotic-resistant bacteria, a phenomenon largely driven by biofilm formation and the acquisition of resistance genes. This study aimed to identify the predominant bacterial species implicated in the etiology of dental caries in Uyo, Nigeria, and to characterize their associated antibiotic resistance genes. A total of 120 clinical samples were analyzed using the VITEK 2 Compact System (bioMérieux) for bacterial identification and antibiotic susceptibility testing. Molecular detection of three extended-spectrum β-lactamase (ESBL) genes—CTX-M, TEM, and OXA—was performed via PCR using standard thermal cycling conditions on an ABI 9700 Applied Biosystems platform. Among the 27 isolates recovered, Gram-negative bacteria constituted 66.7%, with Burkholderia cepacia complex being the most prevalent (25.9%). Burkholderia cepacia exhibited high sensitivity to Amikacin and Tobramycin but showed marked resistance to Ceftazidime. Of the B. cepacia isolates, 6 (85.7%) underwent 16S rRNA sequencing, confirming their identity as Burkholderia cepacia (n=4) and Burkholderia cenocepacia (n=2). CTX-M genes were detected in all sequenced isolates (100%), while TEM genes were present in one isolate (16.7%) and OXA genes were absent. These findings underscore the potential public health threat posed by ESBL-producing B. cepacia complex strains in dental caries, highlighting the urgent need for targeted antimicrobial stewardship and enhanced surveillance in oral healthcare settings.
Co-Authors Abdulkadir, Rasheedat Milan, Charles Onah, Daniel Oche Onwuezobe, Ifeanyi Abraham Shagal, Mohammed Hassan Udoh, Mary Athanasius Yahaya, Musbau Adekunle