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Nnumolu, Michael Chuks
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Antiepileptic Potential of Justicia insularis Leaf Extract in Swiss Mice Elkanah, Nancy; Nnumolu, Michael Chuks; Okokon, Jude Effiom; Ise, Uduak Peter
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.271-275

Abstract

Epilepsy is a prevalent neurological condition characterized by repetitive seizures, necessitating the exploration of efficacious treatments. Justicia insularis, a plant with a historical use in treating convulsions and epilepsy, has garnered attention as a potential antiepileptic agent. This study aimed to investigate the antiepileptic properties of Justicia insularis leaf extract, focusing on generated seizure models in mice. The analysis of variance (ANOVA), specifically one-way ANOVA, was utilized to assess the statistical significance of the data. Seizure models were employed to evaluate the antiepileptic effects of Justicia insularis leaf extract. The p-values obtained from the one-way ANOVA were significant, with values of ap<0.005, bp<0.01, and cp<0.001. These results suggest the statistical significance of the observed effects in the seizure models. This study provides valuable insights into the therapeutic potential of Justicia insularis leaf extract as a treatment for epilepsy. The significant findings underscore the importance of further research into the use of natural medicines for managing epilepsy, potentially offering new avenues for treatment.
Effect of Citrullus lanatus Seeds Extract on Haematological Parameters After Administration with Medroxyprogesterone Acetate on Female Wistar Rats Nnumolu, Michael Chuks; Godspower, Onyeso
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.611-617

Abstract

This study was carried out to investigate the effect of Citrullus lanatus seeds extract on the haematological parameters after administration with medroxyprogesterone acetate on female Wistar rats. Twenty-five rats weighing 170-230 g were divided into five groups containing five rats each. Group I served as control and received only rat chow and water; Group II received rat chow, water and a high dose of MPA only; Group III received rat chow, water, a high dose of MPA and a high dose of extract; group IV received rat chow, water, high dose of MPA and a low dose of extract, and group V received rat chow, water and high dose of extract only. The administration lasted for twenty-eight days after two weeks of acclimatisation. On the twenty-ninth day, the animals were anaesthetised using chloroform, sacrificed and their blood samples obtained via cardiac puncture for haematology analysis. The results showed that the level of haematological parameters significantly increased (p<0.05) in the rats that received a high dose of MPA and a high dose of Citrullus lanatus seed extract compared to the control group. This suggests that MPA affects bone marrow, which produces blood cells, significantly decreasing platelet count, white blood cell count, red blood cell count, haemoglobin count, packed cell volume, mean corpuscular volume, and mean corpuscular haemoglobin concentration. This study also shows that an aqueous extract of Citrullus lanatus seed is potent in increasing the level of haematological parameters when co-administered with MPA.
Co-Authors Elkanah, Nancy Godspower, Onyeso Ise, Uduak Peter Okokon, Jude Effiom