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All Journal Biology, Medicine, & Natural Product Chemistry
Ise, Uduak Peter
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Antiepileptic Potential of Justicia insularis Leaf Extract in Swiss Mice Elkanah, Nancy; Nnumolu, Michael Chuks; Okokon, Jude Effiom; Ise, Uduak Peter
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.271-275

Abstract

Epilepsy is a prevalent neurological condition characterized by repetitive seizures, necessitating the exploration of efficacious treatments. Justicia insularis, a plant with a historical use in treating convulsions and epilepsy, has garnered attention as a potential antiepileptic agent. This study aimed to investigate the antiepileptic properties of Justicia insularis leaf extract, focusing on generated seizure models in mice. The analysis of variance (ANOVA), specifically one-way ANOVA, was utilized to assess the statistical significance of the data. Seizure models were employed to evaluate the antiepileptic effects of Justicia insularis leaf extract. The p-values obtained from the one-way ANOVA were significant, with values of ap<0.005, bp<0.01, and cp<0.001. These results suggest the statistical significance of the observed effects in the seizure models. This study provides valuable insights into the therapeutic potential of Justicia insularis leaf extract as a treatment for epilepsy. The significant findings underscore the importance of further research into the use of natural medicines for managing epilepsy, potentially offering new avenues for treatment.
Effect of Justicia insularis Leaf Extract and Fractions on Oxidative Stress Markers, Liver Function Parameters and Liver Histology of Plasmodium berghei -Infected Mice Enyiekere, Veronica James; Anagboso, Martin Osita; Ise, Uduak Peter; Essien, Grace Emmanuel; Okokon, Jude Efiom; Ebong, Nwakaego Omonigho
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.351-359

Abstract

Justicia insularis (Family-Acanthaceae) is used in Ibibio ethnomedicine to treat malaria. The leaf extract and fractions of J. insularis were investigated for antioxidative stress and hepatoprotective activities in Plasmodium berghei-infected mice. The leaf extract (100-300 mg/kg, p.o.) exerted significant (p<0.05) antimalarial activity against P. berghei infection in curative test with ethyl acetate fraction demonstrating the highest activity.  The extract/fractions treatment caused significant (p<0.05) reductions in liver enzymes (ALT, AST and ALP), total and conjugated bilirubin of the treated infected mice and also decreased significantly (p<0.05) total protein and albumin levels of the treated mice relative to control. The leaf extract and fractions further improved significantly (p<0.05) the levels of oxidative stress markers enzymes and molecules (CAT, GPx, GST, SOD) of the treated infected mice with no significant (p>0.05) effect on GSH. The MDA levels in the livers of the treated infected mice were significantly (p<0.05) reduced relative to control. Histology of liver sections revealed absence or significant reductions in pathological features in infected mice treated with leaf extract (100 mg/kg), DCM and ethyl acetate fractions compared to untreated infected mice. These results suggest that the leaf extract/fractions of Justicia insularis possess antioxidative stress and hepatoprotective potentials, which is an added advantage to its antimalarial property.
Co-Authors Anagboso, Martin Osita Ebong, Nwakaego Omonigho Elkanah, Nancy Enyiekere, Veronica James Essien, Grace Emmanuel Nnumolu, Michael Chuks Okokon, Jude Effiom Okokon, Jude Efiom