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All Journal Biology, Medicine, & Natural Product Chemistry SAINS TANAH - Journal of Soil Science and Agroclimatology
Utami, Setyowati Triastuti
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Biochemistry, Genetics & Molecular Biology Education Medicine & Pharmacology Public Health

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Commercial Incense: Compound Analysis and Its Molecular Docking Studies as Anxiolytic Agents Apsari, Cintya Nurul; Ujiantari, Navista Sri Octa; Rohmah, Zuliyati; Utami, Setyowati Triastuti; Suma, Artania Adnin Tri; Gusnaniar, Niar
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.239-250

Abstract

In the context of Indonesian culture, incense has been traditionally utilized in various rituals. Incense possesses a calming impact and has the potential to reduce anxiety. This physiological response stems from the interplay of chemical components within incense and receptors associated with relaxation, specifically GABAA. This research aims to explore the interaction between substances found in commercially incenses with the GABAA receptors. The compounds of incense were identified through Gas Chromatography-Mass Spectrometry (GCMS) analysis. And there were 54 compounds identified from the 5 incense samples. Next, the ligands employed for docking studies were compounds predicted to traverse the blood-brain barrier (BBB). There were 31 compounds potential of crossing the blood-brain barrier (BBB). Docking results indicated that the majority of tested compounds exhibited notably lower S-scores during receptor interaction, suggesting their potential as anxiety-relieving agents. Furthermore, molecular docking outcomes highlighted that 9-Octadecenoic acid (Z)-, 2-hydroxy-1-(hydroxymethyl)ethyl ester showed the lowest S-score (-6.573). These findings imply that odorant and other volatile organic compounds (VOCs) present in incenses possess the ability to function as anxiety-reducing (anxiolytic) agents, potentially assisting in anxiety treatment.
Re-evaluating the evidence of aflatoxin B1 intercalation into smectite interlayer: a review based on basal spacing data Prastistho, Widyawanto; Apsari, Cintya Nurul; Gusnaniar, Niar; Budianta, Wawan; Promentilla, Michael Angelo B.; Utami, Setyowati Triastuti
SAINS TANAH - Journal of Soil Science and Agroclimatology Vol 22, No 1 (2025): June
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/stjssa.v22i1.92453

Abstract

The bonding mechanism of aflatoxin B1 (AfB1) onto smectite in the batch adsorption test remains a subject of ongoing debate. One key aspect under contention is whether the interlayer of smectite is accessible to the AfB1 molecule. Some researchers contested the possibility of AfB1 intercalation into the smectite interlayer by highlighting the lack of discernible differences in basal spacing value before and after the adsorption experiment. Conversely, others have advanced the opposite argument based on observations indicating an increase in basal spacing value after adsorption. This study aims to resolve the discrepancy through a comparative examination of data from several previous studies that reported basal spacing values derived from X-ray diffraction (XRD) analysis, both before and after adsorption tests. By also considering the characteristic swelling behavior of smectite, this comparative examination explains the differing perspectives. The lack of discernible differences in basal spacing value pre- and post-adsorption tests, which was interpreted as the absence of AfB1 intercalation, was attributed to the fact that the initial samples were inherently in hydrated condition, as indicated by basal spacing values of 1.41 to 1.59 nm, whereas in the dry state, these values would typically be ~0.98 to ~1.0 nm, thereby precluding further expansion. Consistent with a previous study that suggested AfB1 bonding to smectite in hydrated conditions occurred through hydrogen bonding within the interlayer, we propose that the hydration state of smectite will significantly influence AfB1 uptake. Thus, further research of adsorption test to investigate the relationship between AfB1 uptake as a function of the hydration state on smectite minerals is strongly suggested.
Co-Authors Apsari, Cintya Nurul Artania Adnin Tri Suma Gusnaniar, Niar Prastistho, Widyawanto Promentilla, Michael Angelo B. Rohmah, Zuliyati Ujiantari, Navista Sri Octa Wawan Budianta