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All Journal Biology, Medicine, & Natural Product Chemistry Sciences of Pharmacy
Ujiantari, Navista Sri Octa
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Public Health

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Commercial Incense: Compound Analysis and Its Molecular Docking Studies as Anxiolytic Agents Apsari, Cintya Nurul; Ujiantari, Navista Sri Octa; Rohmah, Zuliyati; Utami, Setyowati Triastuti; Suma, Artania Adnin Tri; Gusnaniar, Niar
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.239-250

Abstract

In the context of Indonesian culture, incense has been traditionally utilized in various rituals. Incense possesses a calming impact and has the potential to reduce anxiety. This physiological response stems from the interplay of chemical components within incense and receptors associated with relaxation, specifically GABAA. This research aims to explore the interaction between substances found in commercially incenses with the GABAA receptors. The compounds of incense were identified through Gas Chromatography-Mass Spectrometry (GCMS) analysis. And there were 54 compounds identified from the 5 incense samples. Next, the ligands employed for docking studies were compounds predicted to traverse the blood-brain barrier (BBB). There were 31 compounds potential of crossing the blood-brain barrier (BBB). Docking results indicated that the majority of tested compounds exhibited notably lower S-scores during receptor interaction, suggesting their potential as anxiety-relieving agents. Furthermore, molecular docking outcomes highlighted that 9-Octadecenoic acid (Z)-, 2-hydroxy-1-(hydroxymethyl)ethyl ester showed the lowest S-score (-6.573). These findings imply that odorant and other volatile organic compounds (VOCs) present in incenses possess the ability to function as anxiety-reducing (anxiolytic) agents, potentially assisting in anxiety treatment.
Formulation Optimization of a Thermosensitive Curcumin Hydrogel for Localized Drug Delivery Using Response Surface Methodology Ikhsanudin, Azis; Sulaiman, Teuku Nanda Saifullah; Zai, Khadijah; Ujiantari, Navista Sri Octa
Sciences of Pharmacy Volume 5 Issue 2
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501554

Abstract

Curcumin has been widely reported to exhibit anticancer potential; however, its clinical application is limited by poor aqueous solubility and low permeability. This study aimed to develop a thermoresponsive hydrogel system based on poloxamer 407 and hydroxypropyl methylcellulose (HPMC) for localized curcumin delivery through sol–gel transition at physiological temperature. Curcumin nanoparticles were prepared via ionic gelation and incorporated into hydrogel matrices containing varying ratios of poloxamer 407 and HPMC. Optimization was performed using response surface methodology. pH, gelation time, and viscosity were selected as critical quality attributes reflecting the clinical applicability of in situ hydrogels. The evaluated responses included pH (5–7), gelation time (9–11 min), and viscosity (2000–5000 mPa•s), with model validation based on lack-of-fit > 0.05, high R², a difference between adjusted and predicted R² < 0.2, and adequate precision > 4. Nano-curcumin exhibited a particle size of 423.03 ± 27.80 nm, a PDI of 0.59 ± 0.08, and a zeta potential of −12.47 ± 0.74 mV. The optimized formulation (17.067% poloxamer 407 and 4% HPMC) achieved a desirability value of 0.86, with a pH of 5.85, a gelation time of 9 minutes, and a viscosity of 4389.76 mPa•s. In vitro release followed the Korsmeyer–Peppas model, indicating diffusion-controlled release and confirming the suitability of the optimized thermosensitive hydrogel as a localized curcumin delivery platform.
Co-Authors Apsari, Cintya Nurul Artania Adnin Tri Suma Azis Ikhsanudin Gusnaniar, Niar Rohmah, Zuliyati Sulaiman, Teuku Nanda Saifullah Utami, Setyowati Triastuti zai, Khadijah