Article Per Year (5 Year)
p-Index From 2020 - 2025
0.61
P-Index
This Author published in this journals
All Journal Usadha
Surya Rahadi, I Wayan
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Uji Aktivitas Antibakteri Rebusan dan Infusa Daun Jeruju (Achantus illicifolious) terhadap Bakteri Methicilin Resistant Staphylococcus aureus (MRSA) Maria Dewi, Ni Putu; Cahyaningsih, Erna; Arman Anita Dewi, Ni Luh Kade; Surya Rahadi, I Wayan; Sandhi Kusuma Yuda, Putu Era; Santoso, Puguh
Usadha Vol 3 No 1 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i1.7222

Abstract

Infectious diseases are still a health problem throughout the world, including in Indonesia. One cause of infection that needs to be watched out for is resistance to Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria. Continuous use of antibiotics can cause problems with microbial resistance. Indonesia has various plant species that can actually provide benefits but have not been specifically cultivated. Jeruju leaves (Achanthus ilicifolius) from mangrove plants contain bioactive compounds that have the potential to be antibacterial. The aim of this research is to determine the antibacterial activity of Jeruju leaf decoction and infusion against MRSA bacteria. Antibacterial activity testing uses MRSA bacteria. The results of the phytochemical screening of Jeruju leaf infusion contained secondary metabolite compounds in the form of flavonoids, tannins, saponins and quinones. Meanwhile, the results of the phytochemical screening of Jeruju leaf decoction contained secondary metabolites in the form of tannins, saponins and quinones. Based on the results of research conducted on infusions and decoctions of Jeruju leaves at concentrations of 30%, 60% and 90%, they did not have inhibitory power on the antibacterial activity of MRSA, as seen from the inhibition zone. Zero inhibition zone for MRSA bacteria. It can be concluded that the infusion and decoction of Jeruju (Achantus illicifolious) leaves do not have antibacterial activity against MRSA.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Jelatang (Urtica dioica L.) Terhadap Bakteri Staphylococcus aureus Esti Trisna Putri, Ni Komang; Surya Rahadi, I Wayan; Sukma Sanjiwani, Ni Made
Usadha Vol 2 No 3 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i3.7416

Abstract

Nettle leaf (Urtica dioica L.) is the most widely known species in the urtica genus and has many benefits for the community, namely for medicine, cosmetics and for consumption. Nettle leaves contain alkaloids, flavonoids, and saponins. These compounds can be known to have antibacterial activity. Staphylococcus aureus bacteria are gram-positive bacteria that can produce a yellow pigment, are facultative aerobes and colonies tend to be shaped like grapes. Naturally Staphylococcus aureus is a normal flora in humans, which is often found on the skin, nose and eyes. This study aims to determine the antibacterial activity of nettle leaf ethanol extract (Urtica dioica L.) against Staphylococcus aureus bacteria . The sample used was nettle leaves (Urtica dioica L.) taken in Buruan Village, Kec. Penebel, Kab. Tabanan. This research was conducted using laboratory experimental methods. The ethanol extract of nettle leaves was prepared by the maceration method using 96% ethanol and the viscous extract was obtained using a rotary evaporator . This study used the disc diffusion method with nutrient agar media. The concentrations of the nettle leaf ethanol extract used were 5%, 10%, and 15%. The antibacterial activity test showed that the ethanol extract of nettle leaves could inhibit the growth of Staphylococcus aureus bacteria at each concentration of nettle leaf extract (Urtica dioica L.) with the following inhibition zone diameters: concentrations of 5% (6.55 mm), 10% (1.06 mm), and 15% (0.48 mm). The nettle leaf ethanol extract had the highest antibacterial activity at a concentration of 5%, namely 6.55 mm, which was included in the medium category. Keywords : nettle leaf (Urtica dioica L.), antibakterial, Staphylococcus aureus.
Studi Bioinformatika Kandungan Curzerene Pada Daun Dewandaru (Eugenia uniflora Linn.) Sebagai Antikanker Prostate Melalui Pensinyalan PI3K: Studi Bioinformatika Kandungan Curzerene Pada Daun Dewandaru (Eugenia uniflora Linn.) Sebagai Antikanker Prostate Melalui Pensinyalan PI3K Andriese, Ni Putu Sri Ayu Sevilla Andriese; Santoso, Puguh; Ari Candra, Agung; Surya Rahadi, I Wayan
Usadha Vol 2 No 1 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i1.6733

Abstract

One of the original Indonesian plants that has medicinal properties is Dewandaru (Eugenia uniflora Linn.). Dewandaru shows cytotoxic activity against cancer cells so it has the potential to be used as a drug preparation. The potential compound from the leaves of Dewandaru is Curzerene. This research was conducted to identify the interaction between the compounds of dewadaru leaves and PI3K receptors in prostate cancer. This study uses a computational method known as molecular docking. Bond energies, visualization of bonds, and types of bonds between compounds and receptors were observed. The PI3K receptor has fulfilled the method validation test requirements. The results showed that compounds from the dewadaru plant could inhibit one target protein from prostate cancer which was expressed with the lowest ∆Gbinding value, namely Curzerene compound (-7.65 kcal/mol) in PI3K protein. The interaction between Curzerene compounds has a lower binding energy value when compared to the original ligands at the PI3K receptor. Thus, it can be concluded that the Curzerene compound in the dewadaru plant used in the study has a good interaction with the PI3K receptor in prostate cancer. This compound has the potential to be developed as an anticancer drug. It is necessary to carry out in vivo testing and modification of the structure of the compound so that it can be used as an effective anticancer therapy in prostate cancer. Keywords: Prostate cancer, Curzerene, Dewandaru leaves, In silico
Co-Authors Andriese, Ni Putu Sri Ayu Sevilla Andriese Ari Candra, Agung Erna Cahyaningsih Esti Trisna Putri, Ni Komang Maria Dewi, Ni Putu Ni Luh Kade Arman Anita Dewi Ni Made Sukma Sanjiwani puguh santoso, puguh Sandhi Kusuma Yuda, Putu Era