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All Journal Jurnal Kefarmasian AKFARINDO Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Media Farmasi
Arisanty
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Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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FORMULASI DAN UJI STABILITAS SEDIAAN LOTION EKSTRAK AIR BUAH TOMAT (Solanum lycopersicum L.) Karim, Nuraeni; Arisanty; Rante Pakadang, Sesilia
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.142

Abstract

Tomato (Solanum lycopersicum L.) has antioxidant active compounds that can prevent skin cell damage due to the influence of free radicals. Lotion is a cosmetic product whose consistency is lower than cream, so that the use of lotion can be evenly distributed on the skin. This research purposed to formulated the preparation of tomatoes (Solanum lycopersicum L.) Water Extract lotion and to know the physical quality stability of the preparation of Tomato (Solanum lycopersicum L.) Water Extract lotion. Tomatoes was extracted by using freeze dryer and then it was formulated with concentration 1%, 3%, and 5% by using lotion base that consist of Stearic Acid, Dimethicone, Glycerin, Nipagin, Nipasol, Liquid Paraffin, Cetyl Alcohol, Triethanolamine, Vitamin E, Fragrance, Aquadest. The inspection of preparation quality consist of organoleptic test, homogeneity, pH, dispersion, viscosity, adhesion before and after accelerated stability storage. The results showed that the lotion preparation of Tomato Fruit Water Extract at all concentrations (1%, 3%, 5%) before and after storage was accelerated homogeneously, had a pH ranging from 7 – 7.81, viscosity 2622 – 5180 cp.s, dispersion power. 5.2 – 8 cm, and adhesion ranged from 10.09 – 44.71 seconds. Lotion preparations with concentrations of tomato fruit extract 1%, 3%, 5%, have met the requirements for topical preparations except for formula 1. Key words : Lotion, Tomato Fruit (Solanum lycopersicum L.) Water Extract, Stability Test, Formulation, Skin.
Difusi Total Polifenol Dari Krim Ekstrak Daun Kelor (Moringa Oleifera) Dengan Peningkat Penetrasi Polietilen Glikol (Peg) Asfar, Arfandi; Arisanty; St. Ratnah
An-Najat Vol. 2 No. 1 (2024): FEBRUARI : An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i1.1046

Abstract

Sediaan topikal adalah sediaan yang kegunaannya pada kulit untuk menghasilkan efek lokal seperti sediaan topikal krim. Salah satu bahan yang digunakan dalam sediaan krim adalah daun kelor yang diketahui memiliki kandungan polifenol alami yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan Polietilen Glikol (PEG) sebagai bahan peningkat penetrasi terhadap penetrasi krim daun kelor. Krim dibuat dalam 4 formula yang memiliki variasi konsentrasi PEG 0%, 2,5%, 5% dan 7,5%. Pengujian penetrasi krim daun kelor menggunakan sel Difusi Franz dan membrane selofan sebagai membrane difusi. Hasil penelitian menunjukkan bahwa Formula 1 dengan konsentrasi PEG 2,5% sediaan krim Ekstrak Daun Kelor (Moringae oleifera) memiliki jumlah senyawa polifenol yang terdifusi paling tinggi yaitu, 3,7399 mgGAE/g dengan lama difusi 240 menit. Dari hasil analisis statistic menggunakan One Way ANOVA menunjukkan bahwa tidak terdapat perbedaan yang signifikan (p < 0,05) dari konsentrasi Polietilen Glikol (PEG) setiap formula.
Inkorporasi Ekstrak Daun Jarak Pagar (Jatropha Curcas L) dalam Patch Transdermal Sebagai Anti Hiperglikemi; Formulasi Dan Pankreatik Histopatologi Sukmawati, Muli; Arisanty; Daswi, Dwi Rachmawaty; Stevani, Hendra; Daton, Dicky Alexander
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.1060

Abstract

Incorporation Of Jarak Pagar Leaves Extract (Jatropha Curcas L) In Transdermal Patch As Antihyperglycemic ; Formulation And Pancreatic Histopathology Transdermal patches are known to have a more immediate therapeutic effect and could avoid the risk of side effects that may arise compared to oral. This study aimed to produce Jarak Pagar leaves ethanolic extract transdermal patch (JPL-EETP) to enhance the penetration of Jarak Pagar leaves extract (JPL-EE) to maximize the systemic therapeutic effect of antidiabetics. In addition, easy and enjoyable medication could improve patient compliance. Transdermal patch was prepared by making the formula of JPL-EETP with different concentrations of extract with solvent-evaporated methods. JPL-EETP optimization was carried out by determining the pH, aeration, folding resistance, and organoleptic. Furthermore, the optimal JPL-EETP formulas were followed by the in vivo assay, ex vivo assay, and pancreatic histopathology assay. The JPL-EETP physicall determination were carried out the appropriate of transdermal patch measurements.  F3 with an JPL-EE concentration of 1.75 g can provide an antidiabetic effect on in vivo asay that is as good as oral antihyperglycemic drugs (p>0.05). Ex vivo study confirmed that the gallate acid permeation across the porcine skin of F2 showed higher percentage of permeation of 94,2% respectively after 24 h. The histophatology assay presence no significant difference between the surface area of ​​the islets of Langerhans and the histopathological after administration of metformin or Jarak Pagar leaves extract transdermal patch. The results suggest that Jarak Pagar leaves ethanolic extract transdermal patch is a potential candidate of antidiabetics drug from natural source and can provide a higher patient compliance along with effectiveness in the management and treatment of diabetes which can be easily applied to the skin. Sediaan patch transdermal diketahui memiliki efek terapi yang lebih cepat dan dapat amenghindari resiko efek samping yang mungkin timbul dibanding sediaan oral. Penelitian ini bertujuan untuk membuat ekstrak etanol daun Jarak Pagar (PT-EJPL) yang diformulasikan dalam bentuk patch transdermal untuk meningkatkan efektifitasnya sebagai antihiperglikemi. Patch transdermal dibuat dalam beberapa konsentrasi EJPL dengan metode solvent-evaporated. Karakteristik PT-EJPL ditentukan dengan pengukuran pH, daya lipat, dan uji organoleptik. Penentuan efek antihiperglikemi dilakukan secara in vivo menggunakan tikus wistar putih. Persentase pelepasan fenolik dilakukan secara ex vivo menggunakan kulit babi selama 24 jam. Analisis pakreas histopatologi dilakukan dengan melihat luar area pulau langerhans sebelum dan sesudah perlakuan. Hasil pengujian menunjukkan karateristik patch yang sesuai persyaratan. Formula 3 dengan konsentrasi EEJPL 1.75 g menunjukkan efek antihiperglikemi pakling baik (p<0.05) sejalan dengan hasil uji pelepasan asam gallat pada F3 mencapai 94,2% pada jam ke 24. Analisis histopatologi luas permukaan sel langerhans menunjukkan tidak perbedaan signifikan antara kelompok kontrol dan perlakuan (p>0.05). Penelitian ini berhasil memformulasikan EJPL kedalam sistem penghantaran transdermal dan dapat dipertimbangkan sebagai kandidat antidiabetik herbal.
Co-Authors Asfar, Arfandi Daswi, Dwi Rachmawaty Daton, Dicky Alexander Hendra Stevani Karim, Nuraeni Rante Pakadang, Sesilia Ratnah, St. Sukmawati, Muli