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All Journal Jurnal Kefarmasian AKFARINDO Jurnal Farmasi Journal of Health Management and Pharmacy Exploration (JOHMPE)
Hayu Widyasti, Jena
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Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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UJI AKTIVITAS TONIKUM EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) PADA MENCIT PUTIH JANTAN (Mus musculus) Yeti Mulyati; Dwi Ningsih; Hayu Widyasti, Jena
Jurnal Kefarmasian Akfarindo Vol 9 No 2 (2024)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.306

Abstract

Tonikum merupakan bahan untuk memacu dan memperkuat sistem organ serta menstimulan perbaikan sel-sel tonus otot. Efek tonikum selain diperoleh dari minuman berbahan kimia dapat juga dari tanaman obat seperti daun binahong yang mengandung senyawa flavonoid dan alkaloid yang diduga mempunyai efek tonikum. Penelitian ini bertujuan untuk mengetahui ekstrak etanol daun binahong memiliki efek tonikum dan dosis efektif ekstrak etanol daun binahong pada mencit putih jantan (Mus musculus). Metode ekstraksi daun binahong pada penelitian ini menggunakan maserasi dengan pelarut etanol 70%. Uji aktivitas tonikum menggunakan metode Natatory Exhaustion dan uji gelantung. Parameter yang diamati berupa swimming time dan kemampuan mencit putih jantan bergelantung dengan kontrol negatif Na-CMC 0,5%, kontrol positif kafein 100 mg/kgBB, dosis ekstrak daun binahong 10,92; 21,84; dan 32,76 mg/20 g BB. Data hasil pengukuran dianalisis dengan uji normalitas Shapiro-Wilk Test dan uji homogenitas. Setelah memenuhi syarat, maka dilanjutkan dengan One way ANOVA kemudian uji Tukey. Hasil penelitian menunjukkan bahwa ekstrak etanol daun binahong (Anredera cordifolia (Ten.) Steenis) memiliki aktivitas tonikum pada mencit putih jantan ditandai dengan adanya perbedaan signifikan pada kontrol negatif Na-CMC 0,5%. Dosis efektif dari ekstrak daun binahong (Anredera cordifolia (Ten.) Steenis) yaitu 21,84 mg/20 g BB mencit.
Antipyretic activity test of papaya leaf extract (Carica papaya L.) against peptone-induced male white mice Mayqhuellia, Marsyanda Happy; Hayu Widyasti, Jena
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 2 (2024): August 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i2.437

Abstract

Fever increases body temperature above normal (98.6°F/ 37°C). To treat complaints of fever, antipyretic drugs are given. Papaya leaves are believed to have antipyretic effects. The purpose of this study was to test the antipyretic activity and effective dose of ethanol extract of papaya leaves (Carica papaya L.) against peptone-induced mice. The test animals were grouped into 5 groups consisting of group I (negative control) CMC Na 0.5%, group II (positive control) paracetamol drug 65 mg/KgBB mice, group III papaya leaf ethanol extract 140 mg/KgBW mice, group IV papaya leaf ethanol extract 280 mg/KgBW mice, and group V papaya leaf ethanol extract 560 mg/KgBW mice, with peptone fever inducer 10 mL/kgBW subcutaneously. The body temperature of the test animals was observed every 30 minutes for 240 minutes after peroral administration of the preparation, then obtained data on T0, Tdemam and body temperature measurements at each time. The data was then used to calculate the AUC and the average AUC calculation data was analyzed by Shapiro wilk test and One way Anova test. The results of the study of ethanol extract of papaya leaves have antipyretic effects, namely due to the presence of flavonoids, alkaloids, tannins, steroids, and saponins. Papaya leaf ethanol extract has the most effective antipyretic activity, namely a dose of 560 mg/kg BW, which is comparable to the positive control of paracetamol.
Uji Aktivitas Antihiperglikemia Ekstrak Etanol Daun Delima Putih (Punica granatum L.) pada Mencit Jantan (Mus musculus L.) yang Diinduksi Aloksan Pangesti, Clara; Nopiyanti, Vivin; Hayu Widyasti, Jena
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 2 (2021): Jurnal Farmasi (Journal of Pharmacy), October 2021
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Pomegranate leaves (Punica granatum L.) contain flavonoids as a decrease in blood glucose levels and prevent tissue damage due to oxidative stress. This study aims to determine the effect of white pomegranate leaf ethanol extract on blood glucose levels, body weight, and the effective dose of white pomegranate leaf ethanol extract in reducing blood glucose levels in mice induced by alloxan. A total of 30 male mice were divided into 6 treatment groups, namely group I (normal), group II (negative control of CMC-Na 0.5%), group III (positive control of glibenclamide), group IV (extract 140 mg/Kg BW), group V (extract 280 mg/Kg BW) and group VI (extract 560 mg/Kg BW). The treatment was given for 14 days by measuring blood glucose levels and body weight on days 0, 3,10, and 17. The results of the analysis of blood glucose levels and body weight were carried out statistically through the Multivariate Test and Tukey Post Hoc test, while the decrease in glucose levels analyzed using One-Way Anova test and Tukey Post Hoc test. The results showed that the extract had antihyperglycemic activity in alloxan-induced mice. The ethanol extract of white pomegranate leaves at a dose of 280 mg/Kg BW had an effective antihyperglycemic activity compared to doses of 140 mg/Kg BW and 560 mg/Kg BW which were comparable to the positive control group.
Co-Authors Dwi Ningsih Mayqhuellia, Marsyanda Happy Pangesti, Clara Vivin Nopiyanti