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All Journal Indonesian Journal of Life Sciences
Widjojo, Clara Ayu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology

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The Perception of Undergraduate Students in Jakarta on the Consumption of Cultured Meat Virginia, Jeslin Audrey; Widjojo, Clara Ayu; Inaray, Ivetta Izhora; Ratnasari, Nanda Rizqia Pradana
Indonesian Journal of Life Sciences 2021: IJLS Vol 03 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v3i2.144

Abstract

Cultured meat, which is meat produced by cell culture, is forecasted to be a prominent solution for the growing meat demand. While startups have been established and cultured meat has been marketed in other countries, research about consumer perception is still lacking in Indonesia. The objective of this study is to identify and analyze the customer standpoint, specifically among undergraduate students in Jakarta, regarding cultured meat production and consumption through an online survey. It is hypothesized that there is an effect of being an i3L, and, a biology or food-related major undergraduate student to the cultured meat consumption acceptance. Moreover, it is predicted that there will be a positive change in cultured meat consumption acceptance after watching an educational video included in the survey. Especially, from the group of vegetarians who are motivated to support animal welfare (i.e. No killing of animals) and improve environmental conditions (i.e. Reduce carbon emission). The results showed that study majors and vegetarian status was not significantly correlated with cultured meat acceptance. Nonetheless, previous knowledge about cultured meat positively affects the acceptance. Moreover, the educational video was able to increase the participants’ acceptance. This implies that awareness raising activities, such as advertisements and campaigns, would be effective.
CRISPR-Cas9 Mediated Gene Therapy: Current Advancements and Applications Towards Tay-Sachs and Sandhoff Disease Josefano, Richelle Bertly; Yoel, Abigail; Japri, Beatrice Miranda; Belva, Felicia Lael; Widjojo, Clara Ayu; Hermantara, Rio
Indonesian Journal of Life Sciences 2024: IJLS Vol 06 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v6i2.195

Abstract

Tay-Sachs disease and Sandhoff disease are neurodegenerative diseases that are classified as autosomal recessive lysosomal storage disorders. They are commonly caused by a mutation that occurs in the HEXA and HEXB genes, which are responsible for encoding beta-hexosaminidase-A (Hex A) and beta-hexosaminidase-B (Hex B). Furthermore, Sandhoff's disease symptoms include spinocerebellar ataxia, motor degeneration, sensorimotor neuropathy, tremor, dystonia, and psychosis, which are comparable to Tay-Sachs disease symptoms. The current treatment of Tay-sachs include enzyme replacement therapy, bone marrow transplantation, and administration of genetically modified stem cells with HexA which do not impede neurological dysfunction and were not effective in the long run. On the other hand, there is no standard treatment for Sandhoff but it utilizes bone marrow transplantation which is ineffective. So far, there is only one available gene editing treatment. Therefore, it might be necessary to consider gene editing as a prospective treatment for both diseases, with CRISPR being a primary method. By utilizing Adeno-associated viruses (AAV) as the delivery method for the CRISPR-Cas9 system, it can replace the defective HEXA or HEXB gene with a modified gene termed HEXM, which was found to be the gene codes for the Hex subunit of the same enzyme that is missing in Tay-Sachs and Sandhoff disease. Several challenges of implementing CRISPR-Cas9 technology to treat Tay-Sachs and Sandhoff disease include off-target mutations, unintentional cleavage of the non-targeted sites, and bioethical challenges. Further studies can be explored using various CRISPR-Cas9 systems to improve its efficiency.
Co-Authors Belva, Felicia Lael Inaray, Ivetta Izhora Japri, Beatrice Miranda Josefano, Richelle Bertly Nanda Rizqia Pradana Ratnasari, Nanda Rizqia Pradana Rio Hermantara Virginia, Jeslin Audrey Yoel, Abigail