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All Journal The International Science of Health Journal Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Abbas K. Abbas
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Modification of Sulfadiazine Antibacterial to Promising Anticancer Schiff Base Derivatives: Synthesis and in Vitro Studies Tasnim Tariq Mohammed; Aula Hassoon Obaid; Ghasaq Farouq Hammeed; Abbas K. Abbas
The International Science of Health Journal Vol. 2 No. 3 (2024): September: The International Science of Health Journal
Publisher : Sekolah Tinggi Ilmu Kesehatan Kesdam IV, Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ishel.v2i3.1259

Abstract

The study displays a novel approach for synthesizing imine-sulfadiazine compounds (A and B) by reacting Sulfadiazine with various aldehydes, including 2-chlorobenzaldehyde and 4-pentoxybenzaldehyde. The derivatives (A and B) were characterized using spectroscopic techniques, specifically FT?IR spectroscopy. The synthesized compounds were assessed in vitro against various bacteria, including Streptococcus pneumoniae and E. coli, using the zone inhibition method. The results indicated that specific derivatives possess enhanced antibacterial characteristics compared to the effectiveness of the regular medications. The derivative A was assessed for its anticancer activity against breast cancer MCF-7 cells using the MTT assay, which yielded a favorable outcome within 24 hours.  
Modification of Gemifloxacin Drug Antibacterial to Promising Anti-Prostate Cancer PC3 Azomethine Compounds: Synthesis and in Vitro Studies Rand Thair Abdulkader; Reyam H. Marah; Aqeel Mohamed; Abbas K. Abbas
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.665

Abstract

In this study, we report a novel azomethine derivatives synthesis (H and G) by reacting pure Gemifloxacin drugs with 2-aminobenzaldehyde and 2-methylbenzaldehyde. Spectroscopic techniques, such as FT‐IR spectroscopy, characterized the derivatives (G and H). All the synthesized derivatives (G and H) were evaluated in vitro against microorganisms such as Bacillus subtilis and E. coli by zone inhibition method and screened for antimicrobial activities and anti-Prostate cancer PC3 cell viability cell lines.
Co-Authors Aqeel Mohamed Aula Hassoon Obaid Ghasaq Farouq Hammeed Rand Thair Abdulkader Reyam H. Marah Tasnim Tariq Mohammed