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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Farmaseutik JI-KES (Jurnal Ilmu Kesehatan)
Filliana, Ulfa
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Health Professions Medicine & Pharmacology Nursing Public Health

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Pengaruh Brief Counseling Apoteker terhadap Kepatuhan Pengobatan dan Perbaikan Tekanan Darah Pasien Hemodialisa Yasin, Nanang Munif; Filliana, Ulfa; Kristina, Susi Ari
Majalah Farmaseutik Vol 20, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i3.92562

Abstract

Intervensi hemodialisa memunculkan berbagai komplikasi, paling banyak yaitu hipertensi yang dapat meningkatkan resiko rawat inap dan kematian lebih cepat. Polifarmasi, ketidakpatuhan minum obat, dan kurangnya pemahaman pasien menjadi faktor penyebab target tekanan darah sulit tercapai. Penelitian ini bertujuan untuk mengetahui pengaruh brief counseling apoteker terhadap kepatuhan pengobatan dan perbaikan tekanan darah pasien hemodialisa. Rancangan penelitian quasi-experimental dengan desain pretest-posttest with control group. Intervensi brief counseling dilakukan 1x seminggu selama 1 bulan menggunakan teknik 5A dan alat bantu leaflet pada pasien hemodialisa dengan kriteria inklusi eksklusi selama bulan September-Oktober 2023. Data dianalisis statistik menggunakan uji Paired sample t-test dan Wilcoxon test untuk melihat perbedaan masing-masing kelompok, uji Independent sample t-test dan Mann Whitney test untuk melihat perbedaan antar kelompok setelah intervensi. Sebanyak 57 responden terdiri dari 29 kelompok kontrol dan 28 kelompok intervensi, menunjukkan bahwa kelompok intervensi terdapat peningkatan kepatuhan dengan selisih skor pretest posttest Δ2,71±1,822 dibandingkan kelompok kontrol Δ-0,44±1,152 (p<0,001), perbaikan tekanan darah yaitu penurunan sistolik dengan selisih skor pretest posttest Δ-12,07±8,969 dibandingkan kelompok kontrol Δ-2,55±4,695 (p<0,001) dan diastolik dengan selisih skor pretest posttest Δ-5,03±5,439 dibandingkan kelompok kontrol Δ-0,86±4,420 (p=0,004). Intervensi brief counseling apoteker disimpulkan dapat memperbaiki kepatuhan dan tekanan darah pasien hemodialisa.
Prevalensi dan Hubungan Glukokortikoid dengan Kejadian Efek Samping Hiperglikemia pada Pasien Systemic Lupus Erythematosus Filliana, Ulfa; Aurelia Vernanda, Cindy; Quraisy Aljufri, Achmad
JI-KES (Jurnal Ilmu Kesehatan) Vol. 9 No. 1 (2025): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v9i1.888

Abstract

Abstrak Systemic lupus erythematosus (SLE) adalah penyakit autoimun yang memerlukan pengelolaan terapi jangka panjang dan berkelanjutan terutama keamanan terapi. Glukokortikoid merupakan terapi lini pertama dan memiliki potensi efek samping hiperglikemia paling tinggi. Dampak perburukan penyakit dan rendahnya kesadaran tenaga medis untuk monitoring efek samping obat merupakan tantangan paling besar. Tujuan penelitian ini untuk mengetahui prevalensi efek samping hiperglikemia akibat penggunaan glukokortikoid dan faktor-faktor yang mempengaruhinya. Metode menggunakan penelitian observasional yang dilakukan dengan rancangan retrospektif cross sectional study pada periode 2024 di RSUP Dr. Kariadi Semarang. Hasil penelitian ini yaitu prevalensi kejadian efek samping hiperglikemia akibat penggunaan glukokortikoid sebesar 12.7% pada periode tahun 2024. Data subjek penelitian yaitu 72 pasien, sebanyak 32 pasien mengalami ESO hiperglikemia dan 40 pasien tidak mengalami ESO hiperglikemia. Faktor-faktor yang signifikan mempengaruhi kejadian ESO hiperglikemia yaitu jenis kortikosteroid metilprednisolon (p-value=0,000) dan rute pemberian intravena (p-value=0,000). Kesimpulan penelitian ini yaitu jenis kortikosteroid metilprednisolon menunjukkan faktor yang paling berhubungan dengan kejadian efek samping hiperglikemia akibat glukokortikoid (OR 6.500; 95% CI 2.185-19.333). Kata kunci: glukokortikoid; efek samping obat; hiperglikemia; SLE   Abstract Systemic Lupus Erythematosus (SLE) is an autoimmune disorder requiring prolonged and ongoing therapeutic management, particularly for the safety of the treatment. Glucocorticoids are the first-line therapy and have shown the highest potential for adverse effects on hyperglycemia. The impact of worsening disease and low awareness among medical personnel to monitor adverse drug reactions is the biggest challenges. This study aimed to determine the prevalence of adverse effects associated with hyperglycaemia resulting from glucocorticoid treatment and the factors that influence this condition. Method used was observational research conducted with a retrospective cross-sectional study design in 2024 at Dr. Kariadi Central Public Hospital Semarang.  This study found that the prevalence of hyperglycaemia adverse effects due to glucocorticoid used was 12.7% ​​in 2024. The total subjects of this study were 72 patients; 32 patients experienced hyperglycaemia while 40 others did not. Significant factors influencing the incidence of hyperglycaemia, adverse effect, were the type of corticosteroid methylprednisolone (p-value=0.000) and the intravenous route of administration (p-value=0.000). In conclusion, the type of corticosteroid methylprednisolone is the factor most associated with adverse effects of hyperglycaemia due to glucocorticoids (OR 6.500; 95% CI 2.185-19.333). Keywords: glucocorticoids; adverse drug reaction; hyperglycemia; SLE
Medication Beliefs and Associated Factors Among Heart Failure Patients in Yemen and Role of Regimen Complexity: a Cross-Sectional Study Abdullah, Ramez; Filliana, Ulfa; Candraningrat, I Dewa Agung Diva; Ridhayani, Firda; Mansoor, Abdullah; Oktasari, Sholikhah Rosvita
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.15222

Abstract

Beliefs about medication influence treatment engagement and outcomes in patients with heart failure, yet evidence from low-resource settings such as Yemen remains limited due to under-supported health care systems and low monitoring in health services. To assess medication beliefs among heart failure patients in Yemen and examine factors associated with necessity and concern beliefs, including medication regimen complexity. A hospital-based cross-sectional study was conducted between December 2023 and February 2024 among heart failure patients attending cardiology outpatient clinics in Sana’a, Yemen after ethical approval from the hospital. Data were collected using structured questionnaires, including the Beliefs About Medication Questionnaire (BMQ-Specific) and the Medication Regimen Complexity Index (MRCI). Multivariable linear regression analyses were performed to identify predictors of medication beliefs. A total of 250 patients were included, with a mean age of 51.08±11.47 years, and 65.2% were male. The median total BMQ score was 38.0 (IQR:35–42). Higher necessity beliefs were independently associated with older age (B=0.046, p=0.029), higher educational status (B=−1.240, p=0.030), and a greater number of prescribed medications (B=0.802, p=0.001), whereas greater medication regimen complexity was negatively associated with necessity beliefs (B=−0.276, p=0.003). Regarding concern beliefs, employment status (B=2.605, p<0.001) and longer duration since diagnosis (>3 years) (B=−1.155, p=0.029) were significant predictors, indicating a mild but significant impact. No significant associations were observed between concern beliefs and age, gender, education, income, number of medications, or regimen complexity. Medication beliefs among heart failure patients in Yemen are shaped by both patient and treatment-related factors. The findings have important implications in clinical practice, both clinical pharmacists and cardiologist can consider patients’ perspective to guide intervention design especially simplifying medication regimens and addressing patient-specific concerns.
Co-Authors Abdullah, Ramez Aurelia Vernanda, Cindy Candraningrat, I Dewa Agung Diva Firda Ridhayani Mansoor, Abdullah Nanang Munif Yasin Oktasari, Sholikhah Rosvita Quraisy Aljufri, Achmad Susi Ari Kristina