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All Journal Pharmacy Reports Svāsthya: Trends in General Medicine and Public Health
Putri, Lucienne Agatha Larasati Nugraha
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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In silico molecular docking of luteolin as a potential antihyperpigmentation agent Putri, Lucienne Agatha Larasati Nugraha; Anjani, Ni Luh Ari Krisma; Laksmiani, Ni Putu Linda; Susanti, Ni Made Pitri
Pharmacy Reports Vol. 3 No. 1 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.61

Abstract

Excessive melanin synthesis, often triggered by overexposure to UV rays, is catalyzed by melanogenesis enzymes such as tyrosinase, tyrosinase-related protein 1, and D-dopachrome tautomerase. Derived from natural sources, the flavonoid compound luteolin is explored for its antihyperpigmentation potential. This study assesses luteolin’s efficacy as an antihyperpigmentation agent by analyzing its affinity and bond interactions with melanogenesis enzymes through an in silico approach. Molecular docking, facilitated by HyperChem 8 for test compound optimization and Chimera 1.11.1 for protein preparation, alongside method validation and docking with AutoDockTools 1.5.6, established the protocol’s validity with an RMSD value of ≤3 Å. Docking results reveal luteolin's higher affinity for the target proteins compared to native ligands, with binding energies of -5.63 kcal/mol for tyrosinase, -6.18 kcal/mol for tyrosinase-related protein 1, and -6.54 kcal/mol for D-dopachrome tautomerase. The interaction between luteolin and these proteins involves hydrogen, hydrophobic, electrostatic, and Van der Waals bonds, with amino acid residues His61, Lys129, Arg132 (tyrosinase); His192, His224, Val89 (tyrosinase-related protein 1); and Ile64, Asn73 (D-dopachrome tautomerase) participating in hydrogen bond formation. These findings suggest luteolin’s significant potential as an antihyperpigmentation agent by inhibiting melanogenesis enzymes.
Systematic literature review on sterile injectable dates of use, stability and implications for use Dewi, I Gst A A Gangga Samala; Putri, Lucienne Agatha Larasati Nugraha; Silalahi, Lydia Devy; Dewi, I Gusti Ayu Widha Paramistya; Hapsari, Meivanti Diva; Dewa, Julio Angga Purnama; Sarayawati, Kadek Ayu Mas; Prasetya, I Wayan Sindhu Wahyu; Dewi, Ni Pande Kadek Sinta; Noviyanti, Ni Putu Rika; Sari , Putri Ayu Puspita; Rajeswari, Ni Kadek Ida; Wahyuni, Ni Luh Komang; Wulandari, Dewi; Warditiani, Ni Kadek
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 1 (2025): January 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i1.66

Abstract

Beyond-use date (BUD) is crucial for the stability of injectable preparations. However, there is a knowledge gap and a lack of information regarding BUD determination in injection preparations. Therefore, a systematic review is needed to address the BUD of injection preparations. This study aimed to provide comprehensive insights into the stability, BUD data, and associated implications for injectable preparations through a systematic literature review approach. This study employed a systematic literature review guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The inclusion criteria were research articles from national and international journals discussing the BUD of sterile injection preparations published in the last 10 years. Fourteen of the 19 articles related to BUD were selected for analysis. The analysis revealed that the stability of the 19 sterile injection preparations was significantly influenced by the characteristics of the preparation, storage conditions, and type of drug. These factors substantially affect the effectiveness and safety of drugs. Intravenous sterile injections involve several critical steps to ensure the safety and efficacy of the medications used. Adhering to BUD guidelines for intravenous injections is crucial for maintaining drug quality, which can help prevent infections or adverse reactions in patients. The stability of sterile injection preparations, which is influenced by various factors, has direct implications for BUD determination. This review highlights the importance of considering these factors when determining BUD to ensure patient safety.
Co-Authors Anjani, Ni Luh Ari Krisma Dewa, Julio Angga Purnama Dewi Wulandari Dewi, I Gst A A Gangga Samala Dewi, I Gusti Ayu Widha Paramistya Dewi, Ni Pande Kadek Sinta Hapsari, Meivanti Diva Ni Kadek Warditiani Ni Made Pitri Susanti Ni Putu Linda Laksmiani Noviyanti, Ni Putu Rika Prasetya, I Wayan Sindhu Wahyu Rajeswari, Ni Kadek Ida Sarayawati, Kadek Ayu Mas Sari , Putri Ayu Puspita Silalahi, Lydia Devy Wahyuni, Ni Luh Komang