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All Journal MNJ (Malang Neurology Journal) Jurnal Biologi Tropis Lombok Medical Journal
Susilawati, Ni Nyoman Ayu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Mechanical Engineering Neuroscience Public Health

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SALTWATER FISH CONSUMPTION AND THE RISK OF STROKE IN COASTAL POPULATION Haq, Abiyyu Didar; Harahap, Herpan Syafii; Wahyudi, Safat; Susilawati, Ni Nyoman Ayu
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.13

Abstract

Indonesia, consisting of tens of thousands of islands, has a rather long coastline with relatively high percentage of it is population that lives in the coastal area. High consumption of saltwater fish in the coastal population is an inevitability. Several studies have observed a relation between saltwater fish consumption and the risk of stroke with contradicting results, protective effect on one side and harmful on the other. The protective effect is mainly mediated by the poly-unsaturated fatty acid (PUFA) content of the saltwater fish while the harmful effect is mediated by the sodium content. PUFA exerts its protective effect through it is antioxidant effect on the endothelial wall, anti-inflammatory effect and the activation of anti-apoptotic pathways in the state of ischemic stroke while sodium increases the risk of hypertension which is the main predisposing factor for stroke and induces anatomical remodeling of the endothelial wall as well as functional abnormalities. Several public health interventions have been carried out to mitigate the harmful effect of the sodium content of saltwater fish yet there hasn’t been a specific intervention for coastal population.
Neurorestoration After Traumatic Brain Injury: Innovative Therapies for Restoring Function and Quality of Life Susilawati, Ni Nyoman Ayu; Putri, Siti Noururrifqiyati Juna; Prayitno, Oktavianus; Panjaitan, Melisa Parida Djayanty
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9531

Abstract

Traumatic brain injury (TBI) is a major cause of death and disability globally, with 50 million cases annually and increasing emergency department visits. Despite advances in management, such as decompressive craniotomy and hypothermia, severe TBI still leads to poor outcomes in about 50% of patients, emphasizing the limited effectiveness of conventional therapies. This has led to the development of neurorestorative approaches to enhance brain function and recovery after injury. Literature was sourced from Google Scholar, ScienceDirect, and PubMed, with studies from 2015–2025, in English or Indonesian, and involving human or animal subjects. Neurorestorative strategies include cellular therapies (e.g., mesenchymal stem cells), neurostimulation (invasive and non-invasive methods), pharmacological interventions (e.g., erythropoietin and statins), and supportive therapies (e.g., hyperbaric oxygen). Cellular therapy shows promise in promoting neurogenesis and recovery, though large-scale trials are needed. Neurostimulation has been shown to improve consciousness and neurological function in patients with chronic consciousness disorders, while pharmacological and supportive treatments present mixed results and require more research. Neurorestorative therapies offer hope for TBI recovery, but study limitations, including design and sample size, prevent generalization. Further research and large-scale randomized clinical trials are necessary to ensure safety, effectiveness, and optimal integration of neurorestorative modalities.
Peran Tatalaksana di Bidang Neurorestorasi pada Decompression Sickness (Caisson Disease) Susilawati, Ni Nyoman Ayu; Adre Mayza
Lombok Medical Journal Vol. 3 No. 1 (2024): Lombok Medical Journal Volume 3 Nomor 1
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v3i1.3652

Abstract

Decompression sickness merupakan salah satu penyakit yang ditemukan dalam penyelaman dengan insiden 1 kasus/10.000 penyelam. Data di NTB menyebutkan nelayan di Pulau Bungin, 57, 5% mengalami penyakit ini dengan gejala nyeri sendi dan 11,3 % dengan gangguan pendengaran ringan sampai tuli Penyakit ini terjadi akibat perubahan tekanan yang terjadi secara cepat saat naik ke permukaan pada saat menyelam menimbulkan pelepasan gelembung gas nitrogen yang berdifusi ke dalam darah saat menyelam ke jaringan tubuh. Gejala penyakit ini bisa ringan pada kulit dan sendi sampai berat mengenai sistem respirasi. Terapi yang dilakukan berupa oksigenasi dengan oksigen 100% nasal, rehidrasi dengan cairan infus isotonis dan terapi rekompresi.
Peran Neurorestorasi pada Pasien Post Stroke Susilawati, Ni Nyoman Ayu; Rizqi Al Kasiron; Hidzul Mahidza Falah; Rizkia Wiyani Putri; Siska Julia Cindy W; Herpan Syafii H; Catur Ari Setianto
Lombok Medical Journal Vol. 3 No. 3 (2024): Lombok Medical Journal Volume 3 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v3i3.3960

Abstract

Stroke penyebab utama kecacatan dan kematian ketiga setelah penyakit jantung dan keganasan (Feigin dkk, 2022). Prevalensi stroke di Indonesia (Riskesdas 2018) meningkat 56% dalam 5 tahun (7 kasus/1000 penduduk tahun 2013 menjadi 10,9 kasus/1000 penduduk tahun 2018). Dengan meningkatnya harapan hidup dan faktor risiko stroke, perkiraan jumlah penderita stroke mencapai lebih dari 1 juta orang pada tahun 2050 (Dirjen Yankes, 2024). Neurorestorasi merupakan proses untuk memulihkan, meningkatkan, atau mempertahankan integritas fungsi neurologis dengan strategi neurorestoratif, termasuk fisik (elektronik atau magnetik), kimiawi (obat atau agen kimia), biologis (terapi sel, molekul, bioteknologi, dan rekayasa jaringan), bedah, atau jenis intervensi lainnya, yang dapat memulihkan struktur dan/atau fungsi saraf secara bersamaan. Mekanisme neurorestoratif dalam sistem saraf pusat (SSP) meliputi neuroprotektif, neuromodulasi, neuroplastisitas (neurosinapsis, sirkuit saraf, atau rekonstruksi jaringan), imunomodulasi, regenerasi aksonal, remielinasi, neuroregenerasi (neurogenesis) dan angiogenesis (Huang dan Chen, 2015; Gunduz dkk, 2023).Berbagai metode terapi neurorestorasi dan neurorehabilitasi pasca stroke dapat digunakan meningkatan neuroplastisitas seperti non invasive brain stimulation repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), terapi Stem cell, deep brain stimulation, virtual reality (VR), terapi musik, terapi kovensional seperti terapi fisik, terapi wicara. Terapi kombinasi berbagai modalitas terapi ini terbukti lebih signifikan memberikan hasil yang lebih baik dibandingkan terapi tunggal atau terapi konvensional
Co-Authors Adre Mayza Catur Ari Setianto Haq, Abiyyu Didar Herpan Syafii H Herpan Syafii Harahap Hidzul Mahidza Falah Oktavianus Prayitno, Oktavianus Panjaitan, Melisa Parida Djayanty Putri, Siti Noururrifqiyati Juna Rizkia Wiyani Putri Rizqi Al Kasiron Siska Julia Cindy W Wahyudi, Safat