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All Journal MNJ (Malang Neurology Journal) Jurnal Biologi Tropis
Susilawati, Ni Nyoman Ayu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Neuroscience

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SALTWATER FISH CONSUMPTION AND THE RISK OF STROKE IN COASTAL POPULATION Haq, Abiyyu Didar; Harahap, Herpan Syafii; Wahyudi, Safat; Susilawati, Ni Nyoman Ayu
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.13

Abstract

Indonesia, consisting of tens of thousands of islands, has a rather long coastline with relatively high percentage of it is population that lives in the coastal area. High consumption of saltwater fish in the coastal population is an inevitability. Several studies have observed a relation between saltwater fish consumption and the risk of stroke with contradicting results, protective effect on one side and harmful on the other. The protective effect is mainly mediated by the poly-unsaturated fatty acid (PUFA) content of the saltwater fish while the harmful effect is mediated by the sodium content. PUFA exerts its protective effect through it is antioxidant effect on the endothelial wall, anti-inflammatory effect and the activation of anti-apoptotic pathways in the state of ischemic stroke while sodium increases the risk of hypertension which is the main predisposing factor for stroke and induces anatomical remodeling of the endothelial wall as well as functional abnormalities. Several public health interventions have been carried out to mitigate the harmful effect of the sodium content of saltwater fish yet there hasn’t been a specific intervention for coastal population.
Neurorestoration After Traumatic Brain Injury: Innovative Therapies for Restoring Function and Quality of Life Susilawati, Ni Nyoman Ayu; Putri, Siti Noururrifqiyati Juna; Prayitno, Oktavianus; Panjaitan, Melisa Parida Djayanty
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9531

Abstract

Traumatic brain injury (TBI) is a major cause of death and disability globally, with 50 million cases annually and increasing emergency department visits. Despite advances in management, such as decompressive craniotomy and hypothermia, severe TBI still leads to poor outcomes in about 50% of patients, emphasizing the limited effectiveness of conventional therapies. This has led to the development of neurorestorative approaches to enhance brain function and recovery after injury. Literature was sourced from Google Scholar, ScienceDirect, and PubMed, with studies from 2015–2025, in English or Indonesian, and involving human or animal subjects. Neurorestorative strategies include cellular therapies (e.g., mesenchymal stem cells), neurostimulation (invasive and non-invasive methods), pharmacological interventions (e.g., erythropoietin and statins), and supportive therapies (e.g., hyperbaric oxygen). Cellular therapy shows promise in promoting neurogenesis and recovery, though large-scale trials are needed. Neurostimulation has been shown to improve consciousness and neurological function in patients with chronic consciousness disorders, while pharmacological and supportive treatments present mixed results and require more research. Neurorestorative therapies offer hope for TBI recovery, but study limitations, including design and sample size, prevent generalization. Further research and large-scale randomized clinical trials are necessary to ensure safety, effectiveness, and optimal integration of neurorestorative modalities.
Co-Authors Haq, Abiyyu Didar Herpan Syafii Harahap Oktavianus Prayitno, Oktavianus Panjaitan, Melisa Parida Djayanty Putri, Siti Noururrifqiyati Juna Wahyudi, Safat