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All Journal MNJ (Malang Neurology Journal) Jurnal Biologi Tropis Lombok Medical Journal
Susilawati, Ni Nyoman Ayu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Mechanical Engineering Neuroscience Public Health

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Journal : Jurnal Biologi Tropis

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Neurorestoration After Traumatic Brain Injury: Innovative Therapies for Restoring Function and Quality of Life Susilawati, Ni Nyoman Ayu; Putri, Siti Noururrifqiyati Juna; Prayitno, Oktavianus; Panjaitan, Melisa Parida Djayanty
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9531

Abstract

Traumatic brain injury (TBI) is a major cause of death and disability globally, with 50 million cases annually and increasing emergency department visits. Despite advances in management, such as decompressive craniotomy and hypothermia, severe TBI still leads to poor outcomes in about 50% of patients, emphasizing the limited effectiveness of conventional therapies. This has led to the development of neurorestorative approaches to enhance brain function and recovery after injury. Literature was sourced from Google Scholar, ScienceDirect, and PubMed, with studies from 2015–2025, in English or Indonesian, and involving human or animal subjects. Neurorestorative strategies include cellular therapies (e.g., mesenchymal stem cells), neurostimulation (invasive and non-invasive methods), pharmacological interventions (e.g., erythropoietin and statins), and supportive therapies (e.g., hyperbaric oxygen). Cellular therapy shows promise in promoting neurogenesis and recovery, though large-scale trials are needed. Neurostimulation has been shown to improve consciousness and neurological function in patients with chronic consciousness disorders, while pharmacological and supportive treatments present mixed results and require more research. Neurorestorative therapies offer hope for TBI recovery, but study limitations, including design and sample size, prevent generalization. Further research and large-scale randomized clinical trials are necessary to ensure safety, effectiveness, and optimal integration of neurorestorative modalities.
Co-Authors Adre Mayza Catur Ari Setianto Haq, Abiyyu Didar Herpan Syafii H Herpan Syafii Harahap Hidzul Mahidza Falah Oktavianus Prayitno, Oktavianus Panjaitan, Melisa Parida Djayanty Putri, Siti Noururrifqiyati Juna Rizkia Wiyani Putri Rizqi Al Kasiron Siska Julia Cindy W Wahyudi, Safat