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All Journal Medica Hospitalia Journal of Nutrition and Public Health
Mahendra, Vito
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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The Effect of Sleeve Gastrectomy and Omentoplasty on HOMA BETA Value and Islets of Langerhans in Rats with Type 2 Diabetes Mellitus: The Effect of Sleeve Gastrectomy and Omentoplasty on HOMA BETA Value and Islets of Langerhans in Rats with Type 2 Diabetes Mellitus Cahyono, Chemy Wiryawan; Mughni, Abdul; Susilaningsih, Neni; Nugrahadi, Dimas Erlangga; Mahendra, Vito
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.764

Abstract

INTRODUCTION: WHO predicts an increase in the number of people with diabetes in Indonesia from 8.4 million in 2000 to around 21.3 million in 2030. Another marker for measuring insulin resistance is the homeostasis model assessment-insulin resistance (HOMA-IR). Bariatric surgery is the most effective therapy for patients both in terms of weight loss and improvement in obesity-related diseases such as Type-2 Diabetes Mellitus (DM). OBJECTIVE: This study aims to prove the improvement of HOMA Beta values and Diameter of the islets of Langerhans in type 2 diabetes mellitus rats that underwent Sleeve Gastrectomy and Pancreatic Omentoplasty. METHODS: This study is an experimental post-test control group design study with 18 male Sprague-Dawley rats. Samples are divided into 1 control group and 2 treatment groups (Sleeve gastrectomy and Omentoplasty). Rats’ pancreas and glucose level were measured by using HOMA IR method and Hematoxylin eosin-paraffin block method. Data of islets Langerhans were measured using ANOVA, while HOMA Beta values were measured by Mann Whitney and Kruskall Wallis test. RESULTS: HOMA Beta values in treatment Group P1 (Sleeve gastrectomy) and Group P2 (Sleeve gastrectomy + omentoplasty) are statistically different compared to control group. Islets cells of Langerhans diameter in treatment groups 1 and 2 was not statistically different compared to control group. HOMA Beta Value and Langerhans diameter was correlated moderately. CONCLUSION: Sleeve Gastrectomy and Pancreatic Omentoplasty in type 2 diabetes mellitus rats improved the HOMA Beta values and the diameter of the islets of Langerhans. KEYWORDS: Sleeve Gastrectomy; Omentoplasty; Diabetes mellitus; HOMA Beta; Langerhan's Islet
Impact of Adjuvant Chemotherapy on Nutritional Status and Functional Capacity in Postoperative Stage III Colorectal Cancer Patients Dhanny Akbar, Mohammad; Mahendra, Vito; Setiawan, Eko
Journal of Nutrition and Public Health Vol. 1 No. 2 (2025): Journal of Nutrition and Public Health
Publisher : CV. Dyoqu Publishing Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64780/jnph.v1i2.76

Abstract

Background: Colorectal cancer is one of the cancers with high prevalence in Indonesia. Management generally involves surgery and adjuvant chemotherapy. However, chemotherapy often causes side effects that can affect the nutritional status and functional capacity of patients. Nutritional status and Karnofsky index are important indicators in assessing the quality of life of post-chemotherapy patients. Aims: This study aims to analyze the relationship between adjuvant chemotherapy with nutritional status and Karnofsky index in patients with stage III colorectal cancer after surgery. Methods: This study used an analytic observational approach with a cross-sectional design. A total of 65 stage III colorectal cancer patients at Sultan Agung Islamic Hospital Semarang who met the inclusion and exclusion criteria were analyzed using medical record data. Nutritional status was assessed through body mass index (BMI), and Karnofsky index was classified into good and bad categories. Data analysis was performed using the Chi-Square test. Results: Most patients had BMI in the normal category (58.5%) and Karnofsky index in the good category (64.6%). Statistical test results showed that there was no significant relationship between adjuvant chemotherapy and nutritional status (p = 0.356) or Karnofsky index (p = 0.841). Conclusion: Adjuvant chemotherapy was not significantly associated with nutritional status and Karnofsky index in post-surgical stage III colorectal cancer patients. This study emphasizes the importance of a holistic care approach and nutritional support in maintaining patients' quality of life.
Differences in CEA Levels and Nutritional Status in Stage III Rectal Cancer Patients Undergoing Different Types of Therapy Rizky, Abdullah; Mahendra, Vito; Chodidjah, Chodidjah
Journal of Nutrition and Public Health Vol. 1 No. 2 (2025): Journal of Nutrition and Public Health
Publisher : CV. Dyoqu Publishing Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64780/jnph.v1i2.78

Abstract

Background: Rectal cancer is a type of malignancy with a higher rate of local recurrence compared to colon cancer. Various therapies such as surgery, chemotherapy, and radiotherapy are commonly used for treatment. Monitoring the effectiveness of these therapies can be supported by clinical parameters such as Carcinoembryonic Antigen (CEA) levels and nutritional status measured by Body Mass Index (BMI). Aims: This study aimed to examine the differences in CEA levels and nutritional status among rectal cancer patients receiving different types of therapies. Methods: This was an observational analytic study with a cross-sectional design. The sample consisted of 56 patients with stage III rectal cancer at Sultan Agung Islamic Hospital Semarang during the period of 2018-2024. Data were collected from medical records and included patients who received either surgery + chemotherapy (n = 33) or surgery + chemotherapy + radiotherapy (n = 23). CEA levels were analyzed using the Mann-Whitney U test, and nutritional status was analyzed using the Independent Sample T-Test. Result: The results showed no statistically significant difference in CEA levels between the two therapy groups (p = 0.405). However, a significant difference was found in nutritional status, with patients undergoing radiotherapy showing lower BMI values compared to those without radiotherapy (p = 0.000). Conclusion: CEA levels did not significantly differ between types of therapy in stage III rectal cancer patients. However, radiotherapy was associated with a significant decline in nutritional status. These findings highlight the importance of integrating nutritional monitoring in the management of rectal cancer patients receiving combined therapy
Co-Authors Abdul Mughni Cahyono, Chemy Wiryawan Chodidjah Chodidjah Dhanny Akbar, Mohammad Eko Setiawan Neni Susilaningsih Nugrahadi, Dimas Erlangga rizky, abdullah