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All Journal Indonesian Journal of Biological Pharmacy Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Azzahra, Annisa Maulida
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Penambatan Molekuler Konstituen Kimia Tumbuhan Bawang Dayak (Eleutherine palmifolia (L.) Merr) terhadap Reseptor VHR sebagai Kandidat Obat Antikanker Serviks Pitaloka, Annisa Dyah; Nurhijriah, Chaca Yasinta; Kalina, Kalina; Musyaffa, Hanif Azhar; Azzahra, Annisa Maulida
Indonesian Journal of Biological Pharmacy Vol 3, No 2 (2023): IJBP (Agustus)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v3i2.45221

Abstract

Bawang Dayak (Eleutherine palmifolia (L.) Merr) merupakan salah satu tumbuhan khas yang mengandung senyawa flavonoid yang telah dimanfaatkan oleh masyarakat Dayak di Kalimantan Tengah sebagai obat Antikanker. Kanker Serviks adalah tumor ganas yang berasal dari sel epitel serviks. Tujuan dari penelitian ini adalah untuk menganalisis berbagai kegunaan kandungan metabolit sekunder dan mekanisme kerja dari bawang dayak sebagai antikanker secara in silico melalui metode penambatan molekul pada reseptor Vaccinia H1-related phosphatase (VHR)  menggunakan program AutoDock Tools. Validasi metode telah dilakukan dengan nilai Root Mean Square Deviation (RMSD) yang diperoleh sebesar 0,57Å. Pengujian in silico terhadap senyawa yang terkandung dalam bawang dayak (Eleutherine palmifolia (L.) Merr) didapatkan hasil bahwa  senyawa Eleuthraquinone A memiliki nilai ∆G yang paling rendah dibandingkan senyawa lain dan senyawa senyawa pembanding 5-Fluorourasil, dengan nilai energi ikatan sebesar -9,41 kkal/mol dengan ikatan hidrogen pada residu asam amino GLU122, LEU124, dan LYS61. Senyawa Eleuthraquinone A memenuhi semua aturan Lipinski, mempunyai absorpsi dan distribusi yang baik, dan bersifat mutagen tetapi tidak karsinogen berdasarkan hasil prediksi ADMET.
Penilaian Risiko menggunakan Metode Failure Mode and Effects Analysis (FMEA) terkait Kontaminasi Silang pada Area Pengemasan di Industri Farmasi “XYZ” Azzahra, Annisa Maulida
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.600

Abstract

Cross-contamination occurs due to other previously produced products, other rooms or areas producing different products, and particles from machinery or equipment. Quality risk management can be a preventive measure in reducing the potential for cross-contamination that occurs in the pharmaceutical industry. One part of quality risk management is risk assessment. One of the most common and effective methods is the Failure Mode and Effect Analysis (FMEA) method. This risk assessment is carried out using the stages of risk identification, risk analysis, and risk evaluation using categorization based on the Risk Priority Number (RPN). Based on the risk assessment using the FMEA method regarding cross-contamination in the Packaging area in the "XYZ" pharmaceutical industry, it can be concluded that the results of observations and interviews with operators and Packaging Supervisors identified 19 risks which were categorized as low, medium, high, and very high. Based on the results of the risk assessment obtained, the risk of cross-contamination that needs to be controlled is those with an RPN value of 30 ≤ RPN ≤ 60 (medium); 75 ≤ RPN ≤ 100 (high); RPN ≥ 150 (very high). Therefore, the "XYZ" pharmaceutical industry needs to determine and implement risk control measures. By adequately controlling the potential risk of cross-contamination, it will ensure the safety and quality of the products produced.
Co-Authors Kalina, Kalina Musyaffa, Hanif Azhar Nurhijriah, Chaca Yasinta Pitaloka, Annisa Dyah