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All Journal IDJP (Indonesian Journal of Pharmaceutics) Indonesian Journal of Biological Pharmacy
Pitaloka, Annisa Dyah
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

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Penambatan Molekuler Konstituen Kimia Tumbuhan Bawang Dayak (Eleutherine palmifolia (L.) Merr) terhadap Reseptor VHR sebagai Kandidat Obat Antikanker Serviks Pitaloka, Annisa Dyah; Nurhijriah, Chaca Yasinta; Kalina, Kalina; Musyaffa, Hanif Azhar; Azzahra, Annisa Maulida
Indonesian Journal of Biological Pharmacy Vol 3, No 2 (2023): IJBP (Agustus)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v3i2.45221

Abstract

Bawang Dayak (Eleutherine palmifolia (L.) Merr) merupakan salah satu tumbuhan khas yang mengandung senyawa flavonoid yang telah dimanfaatkan oleh masyarakat Dayak di Kalimantan Tengah sebagai obat Antikanker. Kanker Serviks adalah tumor ganas yang berasal dari sel epitel serviks. Tujuan dari penelitian ini adalah untuk menganalisis berbagai kegunaan kandungan metabolit sekunder dan mekanisme kerja dari bawang dayak sebagai antikanker secara in silico melalui metode penambatan molekul pada reseptor Vaccinia H1-related phosphatase (VHR)  menggunakan program AutoDock Tools. Validasi metode telah dilakukan dengan nilai Root Mean Square Deviation (RMSD) yang diperoleh sebesar 0,57Å. Pengujian in silico terhadap senyawa yang terkandung dalam bawang dayak (Eleutherine palmifolia (L.) Merr) didapatkan hasil bahwa  senyawa Eleuthraquinone A memiliki nilai ∆G yang paling rendah dibandingkan senyawa lain dan senyawa senyawa pembanding 5-Fluorourasil, dengan nilai energi ikatan sebesar -9,41 kkal/mol dengan ikatan hidrogen pada residu asam amino GLU122, LEU124, dan LYS61. Senyawa Eleuthraquinone A memenuhi semua aturan Lipinski, mempunyai absorpsi dan distribusi yang baik, dan bersifat mutagen tetapi tidak karsinogen berdasarkan hasil prediksi ADMET.
Drug Delivery System in Feline Herdiana, Yedi; Wilar, Gofarana; Sofian, Ferry Ferdiansyah; Pitaloka, Annisa Dyah; Nurhijriah, Yasinta; Safira, Rayhan Zarra; Salsabila, Annisa Siti; Z, Maziyatunisa
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.44274

Abstract

The drug delivery system is an attractive field of study since it has several applications in veterinary and human medicine. In the realm of veterinary medicine, the discovery of new routes of administration or new delivery systems to regulate the release of medications is of great importance. Due to the high number of animals and the special issues related to the administration of drugs and their market potential is very large, it is necessary to modify the dosage form to produce an effective and practicable preparation. Cats are the most popular pet in the world, outnumbering dogs by a ratio of three to one. It is vital to understand the prevalent illness patterns and limits of traditional delivery systems to establish appropriate dosage forms for cats. We believe this publication will be of interest to veterinarians and pharmaceutical scientists working in the field.
Co-Authors Azzahra, Annisa Maulida Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Gofarana Wilar Kalina, Kalina Musyaffa, Hanif Azhar Nurhijriah, Chaca Yasinta Nurhijriah, Yasinta Safira, Rayhan Zarra Salsabila, Annisa Siti Yedi Herdiana, Yedi Z, Maziyatunisa